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Search results (Displaying 111 grants)

Total grants
111
Total funders
1
Total recipients
1
Earliest award date
18 Jan 2010
Latest award date
30 Dec 2017
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Vacation Scholarships 2017 - University of Cambridge
<p>Vacation Scholarships 2017 - University of Cambridge</p>
Amount: £21,500
Physiology: A lexicon history
This project entails a historical synthesis of the expression, physiology. Though this term today denotes a specific biomedical field dealing with the study of how living beings work, it has a much broader scientific heritage. The idiom physiologia originally signified 'discourse on nature' (or 'natural philosophy'- the forerunner of today's expression 'science'). The Greek etymon physis ('nature… more
Amount: £4,600
Dissection of mechanisms underlying the development of neuronal lineages.
We will use the developing nerve cord of the Drosophila embryo and larva to investigate elementary organizational principles and their mechanisms that underlie the development of neuronal progenitor cell lineages. We will use genetic methods to label (and manipulate) neuroblast lineages in first instar larval stages, when these have fully differentiated, and show how key features of neuronal diff… more
Amount: £254,576
Interactome analysis of the structure of the trypanosome nuclear lamina and other complexes.
Defining function and the role of proteins in biological processes requires information at many levels. Genome sequences facilitate a parts list. A level of functional definition is possible by gene knockdown or knockout strategies. In the African trypanosome these approaches are powerful, but a complete definition of function requires determining the physiological context in which specific prote… more
Amount: £22,800
Open access award.
Not available
Amount: £250,000
Clinical PhD Programme at the University of Cambridge: 'Functional characterisation of responses to DNA damage in human cells.'
Failure of accurate DNA damage sensing and repairing mechanisms manifest as a variety of human diseases including cancer. Cytotoxic chemotherapy and radiotherapy remain the most beneficial in terms of cancer treatments and largely act through the generation of DNA damage. Accuracy and efficiency of DNA damage detection and repair requires the recruitment and subsequent post-translational modifica… more
Amount: £221,618
Clinical PhD Programme at the University of Cambridge: 'Defining the origin and fate of Fibroblast Activation Protein (FAP) expressing cells in health and disease'.
A population of tumour stromal cells, identified by Fibroblast Activation Protein (FAP) expression, are essential for suppressing the immune response directed toward the tumour. FAP+ cells are present in inflamed tissues, in healing wounds, during embryological development and recent work from our laboratory has found them in a wide range of normal adult tissue, including muscle, bone marrow and … more
Amount: £240,390
Bayesian inference using a norm based face coding scheme in humans
Recently large amounts of evidence have accrued suggesting that the human brain often supports optimal Bayesian inference, but it has not been shown that this is so in face recognition. In parallel a leading hypothesis for the encoding of faces is the so-called norm coding scheme, whereby each face is defined by its position in face-space. In face-space the average face sits at the origin, and, i… more
Amount: £259,443
The epidemiology of glaucoma.
Glaucoma is one of the leading causes of blindness worldwide, second only to cataract. However, unlike cataract, visual loss from glaucoma is irreversible.Uncorrectable loss of vision is associated with threats to independent living,safety and emotional well-being, resulting in increased dependence on social and community services. It has been estimated that if 10% of glaucoma sufferers received … more
Amount: £361,924
Clinical PhD Programme at the University of Cambridge: 'Early life immune and metabolic function and psychotic symptoms in the ALSPAC birth cohort.'
Schizophrenia is associated with proinflammatory changes (increased cytokines in serum and CSF). Recent evidence suggests important effects of hormone leptin on immune system and cognition. Cognitive dysfunction is also prominent in patients with schizophrenia. However, prospective studies are required to establish importance of inflammatory cytokines and their modulators, such as leptin in the p… more
Amount: £224,505
Preserving the material culture of contemporary life science and technology
I propose to undertake research on the role of university museums in preserving the material culture of contemporary life sciences and technology (LS&T) during the academic year 2010-11. The research questions to be addressed are: What is the current role of university museums in Europe in preserving the contemporary culture of life sciences and technology (LS&T)? What are the current aspirations… more
Amount: £25,000
Transgenerational epigenetic inheritance in C.elegans.
Transgenerational epigenetics is the study of changes in gene regulation, inheritable over generations that are not due to changes in the DNA sequence. Although a few examples of epialleles have been observed in nature, and are often associated with inheritable DNA methylation, the molecular mechanisms underlying this alternative type of heredity remain poorly understood. The soil nematode Caenor… more
Amount: £152,106
Amount: £152,106
evolutionary conservation of group B Sox function in Drosophila.
The primary aims of the project are to: 1) perform a comparative in vivo analysis of the genomic activity of two closely related Sox domain transcription factors in four different Drosophila species; 2) determine the evolutionary conservation of the regulatory network driven by the Sox factor Dichaete in neural cells; 3) investigate the conservation in genome wide chromatin accessibility profiles across 4 species of Drosophila.
Amount: £152,106
Elucidating the molecular networks that regulate polarized cell growth, using functional genomics.
Almost every living cell must maintain some degree of polarity, whether permanent or transient, in order to live and function correctly. There are many obvious examples of cell polarity provided by the mammalian system, including epithelial cells, neurons and photoreceptors. However, the fission yeast Schizosaccharomyces pombe provides one of the simplest and most easily studied examples. The rod… more
Amount: £152,106
'"Reproductive tourism": Travelling for conception and the global ART market' to be held in Cambridge on 3-5 December 2010
The proposed meeting will bring together fifteen experts from around the world to discuss the newly emerging and rapidly growing phenomenon of "reproductive tourism". This interdisciplinary workshop will foster a much-needed conversation across the disciplines in order to generate a holistic and informative analysis. The fifteen invited presenters represent outstanding scholarship from a range of… more
Amount: £1,500
"A programme of events by Mary Fissell in Cambridge" to be held in Cambridge form January to July 2011
We seek support to bring Professor Mary Fissell to Cambridge to strengthen and enhance our programme on 'Generation to Reproduction', the core activities of which are supported by a Strategic Award (2009-14).
Amount: £3,900
Cue-induced translational control in axon pathfinding.
The project aims to understand the mechanism of cue-induced local translation in growing axons and how it contributes to axon navigation in the developing visual system. The objectives are:- (i) Identification of transcripts translated in response to specific guidance cues (ii) Discovery of potential regulatory networks for attractive versus repulsive guidance (iii) Investigation of the logic of … more
Amount: £152,106