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Search results (Displaying 93 grants)

Total grants
93
Total funders
1
Total recipients
1
Earliest award date
18 Jan 2013
Latest award date
30 Dec 2017
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Vacation Scholarships 2017 - University of Cambridge
<p>Vacation Scholarships 2017 - University of Cambridge</p>
Amount: £21,500
Population Histories in Context: Reviewing past achievements and future directions.
This meeting uses the occasion of the 50th anniversary of the founding of the Cambridge group for the History of Population to assess the major achievements and the most important future areas of historical demographic enquiry. Four of the six themes and around which the meeting is focused have particularly strong links with medical history and funds are sought to assist in bringing 6 key scholar… more
Amount: £2,500
Amani Research Station - the post-colonial period. A witness seminar.
Support is sought to hold a half-day witness seminar to be held in Cambridge on August 5th 2013 on the period of Africanisation (late 1950s to 1970) at the Amani research station in Tanzania - then the main malaria research site in formerly British Africa. The seminar will involve at least 10 expatriate scientists and technicians, women as well as men, who worked and lived in Amani from the late… more
Amount: £4,000
The impact of murine norovirus infection on the innate immune system.
<table> <tbody> <tr> <td>We &nbsp; propose that the activation of innate immune responses become altered upon &nbsp; infection with persistent versus non-persistent strains of MNV. We further &nbsp; propose that persistent MNV infection affects subsequent immune responses to &nbsp; other pathogens such as Salmonella. 1. To identify the signaling pathways of &nbsp; the innate immune system involve… more
Amount: £18,300
Wellcome Trust PhD Programme for Clinicians at the University of Cambridge.
<p>Two thirds of breast cancer is luminal, driven by oestrogen signalling via overexpressed oestrogen receptor. The pioneer transcription factor FoxA1 is required for transcription of ER target genes driving cell growth in both drug-sensitive and resistant contexts. The aim of the proposed research is to characterise<br />FoxA1 regulatory factors to provide mechanistic insight into how FoxA1 func… more
Amount: £229,922
Wellcome Trust PhD Programme for Clinicians at the University of Cambridge
<p>Regular physical activity prevents cardiovascular disease, diabetes, obesity, some cancers, as well as being important for bone health, mental health and well-being. Despite its importance, the proportion of adults who are sufficiently active in the UK remains low. Promoting active travel (walking and cycling) may be one means to shift physical activity levels, and realise large population hea… more
Amount: £274,582
Wellcome Trust PhD Programme for Clinicians at the University of Cambridge.
This proposal aims to delineate the role of the epigenetic regulator EZH2, whose function is perturbed in a number of cancers including leukaemia and lymphoma, in the induction and maintenance of acute myeloid leukaemia (AML). AML is an aggressive haematological malignancy with an overall poor outlook and limited treatment options in the relapse setting. We aim to provide genetic proof of the req… more
Amount: £229,922
Wellcome Trust PhD Programme for Clinicians at the University of Cambridge.
<p>Human development progresses from a single fertilised egg to a multicellular organism composed of cells highly-organised into functional units&nbsp; called organs. All the various cells&nbsp; are generated from the same&nbsp; precursor and the processes by which&nbsp; the different cell types&nbsp; emerge is poorly understood. The chromatin structure, transcriptome and proteome may uniquely de… more
Amount: £328,106
Wellcome Trust PhD Programme for Clinicians at the University of Cambridge.
<table> <tbody> <tr> <td>Diffuse &nbsp; large B cell lymphoma (DLBCL) is the commonest Non Hodgkin Lymphoma (NHL) &nbsp; among adults and despite aggressive chemoimmunotherapy ~40% of patients die &nbsp; of their disease. The heterogeneity of clinical response is likely &nbsp; representative of biologically distinct subtypes with distinct oncogenic &nbsp; pathways. Phosphoinositide-3 kinases (PI3… more
Amount: £237,309
MH Master's
Not available
Amount: £22,345
Wellcome Trust PhD Programme in Mathematical Genomics and Medicine.
<p>Breast cancer is one of the I eading causes of cancer death in women and is widely considered a heterogeneous disease with <em>very </em>different therapeutic responses and outcomes. Whi le recent advances have I ed to the integration of the genomic and transcriptomic architecture of breast cancers to refine the molecular classification of the disease, the methylation landscape has received le… more
Amount: £159,401
Wellcome Trust PhD Programme in Mathematical Genomics and Medicine.
<p>Spontaneous activity during development has been observed in many parts of the nervous system, and is believed to play an important role in shaping neural connectivity. An efficient method of studying neural activity in vitro is through the use of Multi-Electrode Arrays (MEAs), which allow for the simultaneous recording of the electrica l activity of large networks o f neurons.</p> <p>Our proj… more
Amount: £159,401
Wellcome Trust PhD Programme in Mathematical Genomics and Medicine.
<p>Myc is a key oncogene in many cancers occurring across a diverse range of tissues. tn order to better understand and trea t such cancers, it is vital that we understand how the opposing functions of Myc, proliferation and apoptosis, are balanced and regulated in healthy ti'ssue, and how this goes wrong in cancer. The aim of this research project is to build a comprehensive executable model of … more
Amount: £159,401
Wellcome Trust PhD Programme in Mathematical Genomics and Medicine.
<p>Haematopoiesis occurs in two distinct waves during development, namely transient primitive haematopoiesis and definitive haematopoiesis that persists into adulthood. Many important questions remain unanswered about the earliest stages of blood development. For example, there are debates on the identity of the ini tial early mesodermal cells that give rise to the H SCs, as well as the factors t… more
Amount: £159,401
Identification of novel molecular mechanisms of HIV latency using forward genetic screens
The latent viral reservoir remains the major block to HIV eradication and transcriptional repression is thought to be the predominant mechanism of silencing latent HIV.However, multiple mechanisms of repression are likely to be responsible and finding a cure for HIV is clearly dependent upon an improved understanding of the molecular mechanisms of latent HIV infection. Here, I propose to use forw… more
Amount: £159,305
A neurocomputational investigation of Pavlovian-instrumental interactions in avoidance.
This proposal has three aims. Firstly, I will characterise the neural computations underlying model-based and model-free avoidance using fMRI in healthy subjects. To do so, I will adapt an existing appetitive paradigm to test if the existing framework can capture human avoidance behaviour. I will seek convergent evidence by comparing a standard version to a version designed to shift individuals t… more
Amount: £250,000
Dissecting the mechanisms of metaboregulatory thermogenesis
The recent discovery of brown adipose tissue (BAT) in adult humans makes possible a new therapeutic approach to treat obesity, by activating endogenous BAT or making white adipose tissue more like BAT. To understand how to achieve these aims, physiological activation of BAT must be understood. Whiles much is known about thermoregulatory thermogenesis, the neuronal networks regulating metabregulat… more
Amount: £10,818
Defining the mechanisms by which maternal diet-induced obesity programmes central control of palatable food intake
In light of growing evidence for a transgenerational component in the current human obesity epidemic, it is important to understand how maternal environment affects the long-term health of the developing foetus. In animal models, maternal over-nutrition has been shown to programme a metabolic syndrome-like phenotype and hyperphagia in the offspring. In this project, we propose to use anestablishe… more
Amount: £4,300