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Search results (Displaying 52 grants)

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Earliest award date
24 Jan 2017
Latest award date
26 Nov 2018
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Amount: £16,250
Youth, gender and teenage sexual counselling in Britain: The making of the Brook Advisory Centre, 1964-2000
<p>This research uses the history of Brook Advisory Centres (BAC) as a case study through which to reassess the history of teenage sexuality and of the anxieties it caused in postwar Britain. From the first Centre opened in 1964 in London to the present, BAC has been an important provider of contraceptive advice and sexual counselling for unmarried people and teenagers. Although the centres have … more
Amount: £155,453
Contribution of transposable elements in cell fate decision
<p>Transposable elements (TEs) are long known to be expressed in different cells during early mammalian development. However, the role of TEs in cellular differentiation has remained elusive. This proposal aims to develop new experimental and computational methods to understand the role of TEs in cellular differentiation. Single cell (sc) RNA sequencing (RNA-seq) has been developed extensively in… more
Amount: £300,000
Mechanisms of epithelial polarity in flies and mammals
<p style="margin-left: 0cm; margin-right: 0cm">AS/A/GCSE-level biology specifications have recently shifted toward an increased focus on practical skills<sup>1</sup>that teachers and schools don&rsquo;t necessarily have the equipment or knowledge to confidently foster across the biology curriculum<sup>2</sup>.&nbsp;The Scientists' Collaborative Project with Educators (SCoPE) is a pilot public eng… more
Amount: £42,756
The Genetic Basis of Congenital Hypothyroidism
<p>I have already identified 2 novel genetic causal variants for congenital hypothyroidism (CH) by whole exome sequencing (WES); IGSF1 defects in central hypothyroidism and SLC26A7 in dyshormonogenetic CH. I will therefore continue this strategy to identify further genetic causes of CH. I will expand my CH cohort, enriched for probability of genetic mutations. After excluding candidate gene defec… more
Amount: £214,297
Vacation Scholarships 2017 - University of Cambridge
<p>Vacation Scholarships 2017 - University of Cambridge</p>
Amount: £21,500
Cholera vaccine effectiveness in Nsanje and Chikwawa, Malawi
<p style="margin-left: 0cm; margin-right: 0cm">Following the 2015 oral cholera vaccine (OCV) mass campaign of 160,000 people in Nsanje District, Malawi, the International Vaccine Institute (IVI) was funded to setup diarrheal disease surveillance in Nsanje and adjacent Chikwawa districts. Surveillance is ongoing at&nbsp;<u>22 and 18 health care facilities</u>in Nsanje and Chikwawa, respectively. R… more
Amount: £311,974
Ultrastructural imaging
<p>This application is for funds to purchase a Transmission Electron Microscope (TEM) and necessary accessories to enable post-embedding immuno-electron microcopy to be performed. We also request funds for salary support for a full-time specialist technician to oversee tissue preparation, sectioning and microscope operation.&nbsp; The microscope will be located within the imaging facility within … more
Amount: £251,744
Rapid spatial imaging of subcellular dynamics
<p>Dynamic cell biological processes such as trafficking and signalling are characterized by weak and transient interactions, which occur in an intrinsically noisy biochemical environment. State-of-the-art live cell imaging equipment is therefore essential for robust localization and tracking of key regulators, allowing temporal relationships and causal mechanisms to be established. To this end, … more
Amount: £300,420
Menstruation and the moon in early modern England
<p>The association of menstrual synchrony with the moon relates back to ancient mythologies. Historians largely dismiss the relevance of a lunar theory of menstruation by the Middle Ages, but&nbsp;the moon&rsquo;s ability to disturb a woman&rsquo;s womb through her menstrual blood was continuously discussed by early modern medical and natural philosophical writers. This project asks how the sympa… more
Amount: £100,057
Neural circuits underlying fertility
<p>This programme aims to establish in detail the characteristics and <em>in vivo</em> significance of the arcuate (ARN<sup>KISS</sup>) and rostral periventricular area of the third ventricle (RP3V<sup>KISS</sup>) kisspeptin neurons in driving the pulsatile and surge patterns of luteinising hormone (LH), respectively. Genetic cFOS-dependent activation and rabies trans-synaptic strategies will ena… more
Amount: £100,000
Unbiased in vivo CRISPR screen to identify novel T-cell immune checkpoints for cancer immunotherapy
<p>Harnessing the anti-tumour potential of T-cells for cancer treatment has been successful for a number of malignancies. The blockade of immune checkpoints, such as the T-cell receptor PD-1, reduces tumour burden in patients and can lead to durable cures for some. Treatment efficiency is further improved when PD-1 is targeted simultaneously with other checkpoints such as CTLA4 or LAG3. Despite t… more
Amount: £250,000
The role of the Wallerian axon-death pathway in neuronal and axonal vulnerability in Parkinson's disease
<p>Parkinson&rsquo;s disease (PD) involves preferential loss of substantia nigra pars compacta (SNc) dopaminergic neurons and their projecting axons to the striatum. SNc neurons have huge, highly branched and vulnerable axons,<strong> </strong>whose distal ends are lost first in PD, so preventing this will be essential for any disease modifying therapy.</p> <p>Our preliminary data suggest the in… more
Amount: £250,000
From Cures to Courts of Justice: The Medical Encounter and Social Order in Early Modern Spain
<p>Early modern encounters have mainly been studied as transactions between individual sick people and their healers. This project shifts the focus by placing encounters within the communities that structured early modern lives and the practices and expectations of social order that shaped them. The variety of encounters that took place in the Catholic kingdom of Castile provides an ideal case st… more
Amount: £147,847
Applying causal interventions to brain networks underlying adaptive perceptual decision making.
<p>The contribution of individual brain regions to perception is not static, and is determined both by task experience and particular stimulus demands. To investigate these dynamic contributions, I propose to use non-invasive brain stimulation combined with electrophysiological measurements. This combination will provide a window into the dynamics of causal relationships between behaviour and spe… more
Amount: £250,000
Putting genomic surveillance at the heart of viral epidemic response.
<p>This proposal is to develop an end-to-end system for processing samples from viral outbreaks to generate real-time epidemiological information that is interpretable and actionable by public health bodies. Fast evolving RNA viruses (such as&nbsp;Ebola, MERS, SARS, influenza etc) continually accumulate changes in their genomes that can be used to reconstruct the epidemiological processes that dr… more
Amount: £482,639
Mobile Sensing of Altered EveryDay Function in Early Alzheimer's Disease (MEDEA)
Wearable technologies such as smarlwatches and smartphones and are now widely used in the general population. The aim of this study is to develop a suite of wearables and mobile based apps for passive sensing of everyday behaviours in order to detect behavioural changes that occur in brain disorders such as Alzheimer's disease. This suite would have the potential to meet the global need for low c… more
Amount: £285,740
Understanding Medical Black Boxes: A Philosophical Analysis of AI Explainability
<p>I plan during the next two years to develop a major, multi-year project into AI explainability in medical contexts. This project will connect existing literatures in philosophy of science, philosophy of medicine and medical ethics, where problems of understanding and explanation have been extensively studied, to the emerging literature on explainability in machine learning and the ethics of AI… more
Amount: £86,561
Liability for Harms Caused by Artificial Intelligence in Healthcare
<p>How will legal liability be assigned when an AI system causes harm? &nbsp;Does the law need reform?&nbsp; In a report&nbsp;published earlier this year, the House of Lords Select Committee on Artificial Intelligence identified these as crucial questions for on-going innovation in the AI sector.&nbsp; &nbsp;We will&nbsp;explore these questions in the healthcare context, providing an analysis of … more
Amount: £55,719