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Search results (Displaying 50 grants)

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Earliest award date
24 Jan 2017
Latest award date
12 Nov 2019
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Amount: £11,072
Darwin Tree of Life
<p>Life has evolved from a single origin to generate &gt;1.5 million eukaryotic species. Sequencing all species will provide an inventory of life, transform understanding of evolution, catalogue eukaryotic gene&nbsp;toolkits for biology and biotechnology, and enable monitoring of ecosystems under increasing stress. The Darwin Tree of Life (DToL) is a new initiative that will exploit long read tec… more
Amount: £264,009
Vacation Scholarships 2017 - University of Cambridge
<p>Vacation Scholarships 2017 - University of Cambridge</p>
Amount: £21,500
Understanding the role of ionocytes in a cystic fibrosis (CF) context using human induced pluripotent stem cell (hiPSC)-derived airway epithelial cells (AECs).
Cystic Fibrosis (CF) affects over 10000 people in the UK. It is a recessive monogenic disease caused by a double mutation in the gene encoding for CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) and it affects multiple tissues, especially the lung. There is still no cure for this disease and patients require life-long treatment and eventually lung transplantation. This projects aims t… more
Amount: £300,000
Biomolecular condensation of hairpin proteins coordinates cytoplasmic clients to spatially distinct microdomains of the ER membrane
The endoplasmic reticulum (ER), as a single continuous membrane network, coordinates a variety of biological processes across the entire cell, providing a platform for the spatiotemporal segregation of cytoplasmic biochemistry – a crucial feature for cell survival. Despite this, our understanding of how the ER corrals most cytoplasmic clients to specific sites on its membrane remains slim. ER st… more
Amount: £300,000
How do sugar-sweetened beverage taxes really work? A complexity-informed synthesis to guide best-practice development
Sugar-sweetened beverage (SSB) taxes are intended to reduce SSB consumption, and thereby reduce obesity and type 2 diabetes rates. However, SSB taxes vary greatly in terms of design and have been introduced in a variety of different contexts. It is unlikely that each of these taxes work in the same way. My goals are to 1) improve our understanding of how SSB taxes operate, and 2) produce evidence… more
Amount: £300,000
Living Assessment: measurement, thresholds and the health of disabled and at-risk children in England, 1989-present
<p><em>Living Assessment </em>will explore two assessments of children in England since 1989: attempts to measure the support requirements of disabled children; and attempts to measure threats of harm to children&rsquo;s health and development in statutory social work practice. How have measurements been made about how and when state provision is necessary? How have thresholds for provision opera… more
Amount: £290,128
The role of FUS phase transition in axonal mRNA localisation and translation
<p>The neuropathological hallmark of the two closely related neurodegenerative diseases, ALS and FTD, is the presence of poorly soluble intracellular protein aggregates consisting of low-complexity domain-bearing RNA-binding proteins (RBPs). Intriguingly, these proteins are also key components of liquid-like ribonucleoproteins (RNPs) mediating diverse physiological processes, including transporti… more
Amount: £300,000
Generating a global view of cell lineage trees during early mouse embryo development
<p style="margin-left: 0cm; margin-right: 0cm">Understanding the routes through which a single cell populates the adult organism is one of the most fundamental yet elusive areas of biology. This project aims to use recent innovations in single-cell technology to generate a blueprint of cell fate decisions during early mouse development, and to examine the mechanisms behind the regulative nature o… more
Amount: £300,000
Bridging the gap between biological plausibility and function in models of prefrontal cortex
<p>Prefrontal cortex (PFC) plays a fundamental role when we make complex decisions. However, there are very few biologically plausible neural-network models that can explain PFC activity during decision making.&nbsp;Additionally, most studies focus on sensory information that does not change during&nbsp;trials and decisions must be made at specific&nbsp;times, unlike our more dynamic&nbsp;natural… more
Amount: £300,000
“Killing me softly”: role of forces in stiffness-dependent tumour-cell killing by T cells
<p style="margin-left: 0cm; margin-right: 0cm">My research proposal aims to study the influence of forces on immune cell activation and killing during tumour cell/target cell engagement.&nbsp;&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm">T cells have been reported to be stiffness dependently activated, but while this phenomenon is well known, the underlying mechanism remains unclear.… more
Amount: £300,000
From Cures to Courts of Justice: The Medical Encounter and Social Order in Early Modern Spain
<p>Early modern encounters have mainly been studied as transactions between individual sick people and their healers. This project shifts the focus by placing encounters within the communities that structured early modern lives and the practices and expectations of social order that shaped them. The variety of encounters that took place in the Catholic kingdom of Castile provides an ideal case st… more
Amount: £147,847
Applying causal interventions to brain networks underlying adaptive perceptual decision making.
<p>The contribution of individual brain regions to perception is not static, and is determined both by task experience and particular stimulus demands. To investigate these dynamic contributions, I propose to use non-invasive brain stimulation combined with electrophysiological measurements. This combination will provide a window into the dynamics of causal relationships between behaviour and spe… more
Amount: £250,000
Putting genomic surveillance at the heart of viral epidemic response.
<p>This proposal is to develop an end-to-end system for processing samples from viral outbreaks to generate real-time epidemiological information that is interpretable and actionable by public health bodies. Fast evolving RNA viruses (such as&nbsp;Ebola, MERS, SARS, influenza etc) continually accumulate changes in their genomes that can be used to reconstruct the epidemiological processes that dr… more
Amount: £482,639
ISA-InterMine: accelerating and rewarding data sharing
Diversity amongst staff and students in higher education is still demonstrably unequal, both in gender balance and ethnic balance (https://www.ecu.ac.uk/about-us/he-equality-challenges). Similarly, open source software developers self-report to be over 90% male and 15% or less self-report as BME (https://osf.io/preprints/socarxiv/qps53). InterMine, as an open-source biological data warehouse, oc… more
Amount: £18,500
Biomedical Vacation Scholarship Programme - University of Cambridge
<p>This award is for 6 students per year for 5 years. It includes ?a salary at the national living wage plus holiday pay and national insurance or equivalent,?as well as?funds to cover or significantly subsidise accommodation and travel (&pound;1500 outside of London and up to &pound;2000 in London).??? It includes &pound;500 to each studentship towards research expenses.??? Unspent funds can be … more
Amount: £166,500
Biocontainment Level 2 high-parameter FACS: applications for the Cambridge biological sciences community
<p><strong>Provision of cutting edge cell-sorter, with class II biocontainment to allow flexible workflows as applied to a broad range of studies within the Cambridge biomedical research community.</strong></p> <p>The acquisition of a CL2 high-parameter cell-sorter will provide critical ability to purify live-cell populations. This capability is desperately needed to match the explosive growth i… more
Amount: £479,450