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Earliest award date
24 Jan 2017
Latest award date
30 Sep 2020
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The Cambridge History of Medicine
This application is for support to develop a proposal for The Cambridge History of Medicine in six volumes. As General Editor, I will meet with a team of a dozen volume editors at a series of workshops to ask fundamental questions about what the history of medicine is, what it should be, and how best to represent it in these books.
Amount: £96,402
Vacation Scholarships 2017 - University of Cambridge
<p>Vacation Scholarships 2017 - University of Cambridge</p>
Amount: £21,500
From Cures to Courts of Justice: The Medical Encounter and Social Order in Early Modern Spain
<p>Early modern encounters have mainly been studied as transactions between individual sick people and their healers. This project shifts the focus by placing encounters within the communities that structured early modern lives and the practices and expectations of social order that shaped them. The variety of encounters that took place in the Catholic kingdom of Castile provides an ideal case st… more
Amount: £147,847
Applying causal interventions to brain networks underlying adaptive perceptual decision making.
<p>The contribution of individual brain regions to perception is not static, and is determined both by task experience and particular stimulus demands. To investigate these dynamic contributions, I propose to use non-invasive brain stimulation combined with electrophysiological measurements. This combination will provide a window into the dynamics of causal relationships between behaviour and spe… more
Amount: £250,000
Putting genomic surveillance at the heart of viral epidemic response.
<p>This proposal is to develop an end-to-end system for processing samples from viral outbreaks to generate real-time epidemiological information that is interpretable and actionable by public health bodies. Fast evolving RNA viruses (such as&nbsp;Ebola, MERS, SARS, influenza etc) continually accumulate changes in their genomes that can be used to reconstruct the epidemiological processes that dr… more
Amount: £482,639
Fractionating the human frontoparietal cortex: combining meta-analytic and real-time optimization approaches
<p>Disruptions in the same set of frontal and parietal brain regions are seen across a striking range of psychiatric and neurological conditions. This network of regions has been referred to as <em>multiple-demand</em> (MD) system and can be divided into at least two closely coupled subnetworks. However, despite extensive research efforts, the specific functional mechanism each subnetwork support… more
Amount: £250,000
Dynamic neural remapping across the sleep-wake cycle: A mechanistic link between sensory re-organisation and GABA
<p>Across a single day, we undergo behavioral, physiological and neurochemical changes, from vigilant wakefulness to unconscious sleep. Despite the loss of consciousness, sensory processing continues in sleep. Attempts to assess the degree to which sensory processing differs between wakefulness and sleep have yielded contradicting results with studies showing greater, smaller or comparable respon… more
Amount: £99,935
Master's Award in Humanities and Social Science
<p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;In my three essays, I will explore case studies of British biotechnology and bioethics since the 1960s. My first essay will investigate the history of organ donation regulation in the UK by focusing on two pieces of legislation: the Human Tissue Act of 1961 and the Human Organ Transplants Act of 1989, which aimed to regulate the procurement of cad… more
Amount: £28,440
Exploring Disorganised Attachment: Unravelling Developmental Pathways and Outcomes using Data Mining
<p>Disorganised attachment is an important assessment of infant mental health, introduced by Main and Solomon (1990). Disorganisation is thought to result from an infant having in some way experienced trauma within the context of the relationship with their caregiver (e.g. observing severe domestic violence). Infants classified as disorganised have an&nbsp;elevated risk of psychological problems,… more
Amount: £25,976
Amulets and the material culture of healing
<p>The goal of this project is to investigate how amulets represent varying forms of value and power across differing chronologies. The Science Museum's collection will allow me to comprehensively examine a diverse range of objects, and research different forms of medical, magical and scientific worth and potency unavailable by studying textual sources alone. This project will ask three questions… more
Amount: £15,523
‘Pre-embryos’ Revisited: a historical sociology of translational biology
<p>This project will revisit the debates on human fertilisation and embryology that took place after the release of the Warnock report in 1984 and ended with the enactment of the Human fertilisation and Embryology Act in 1990. Firstly, it will ask how developmental biologist Dame Anne McLaren (1927-2007) used the scientific concept of the &lsquo;pre-embryo&rsquo; as a rhetorical device in the deb… more
Amount: £135,903
Attachment and the transgenerational effects of loss, abuse and trauma: Exploring and testing classic ideas through historical analysis and developmental science
<p>Since it was introduced by John Bowlby, attachment research has been among the most influential paradigms for understanding the social underpinnings of infant mental health and transgenerational mental health. However, an odd artefact of the way a major research instrument was constructed in the 1980s by Mary Main has meant that to date attachment research has largely treated loss, abuse, and … more
Amount: £97,935
Fundamental mechanisms controlling human energy homeostasis
<p>Obesity and associated diseases such as type 2 diabetes, cardiovascular disease and some cancers represent a significant health burden. My overall aim is to identify new therapeutic strategies for severe obesity. Using extensive genetic and clinical data on unique cohorts of individuals at both extremes of the weight distribution (severe obesity and thinness), we will comprehensively map the m… more
Amount: £50,000
Understanding drug resistance in cancers with DNA repair mutations
<p>The DNA damage response (DDR) is critical for maintaining genome stability. Cancer mutations have been identified in many genes linked to DNA repair, for example in ~20% of primary prostate cancers. Genes like BRCA1 are essential for mediating high-fidelity template-based Homologous Recombination (HR) repair of DNA double strand breaks (DSB). The absence of BRCA1 increases mutagenic repair and… more
Amount: £233,577
Visualizing Citizen Voice in a Moment of 'Big Data'
<p>Visualizing Citizen Voice in a Moment of 'Big Data'</p>
Amount: £21,350
Schwann cell-axonal communication during axonal degeneration and regrowth
<p>Myelinating and non-myelinating Schwann cells are reprogrammed after nerve injury into repair Schwann cells, specialized for maintaining survival of injured neurons and supporting axonal regeneration. This process is regulated by Schwann cell-intrinsic signals, such as the transcription factor c-Jun, however few other candidates have been identified. It is, currently, unknown how Schwann cell … more
Amount: £426,876
B cell dependent susceptibility to airway infection in Activated PI3K-delta syndrome
<p>PI3K&delta; plays a critical role in development of the immune system. We have identified a cohort of patients with an immunodeficiency caused by gain of function mutations in PI3K&delta;, which we have named Activated PI3K&delta; syndrome (APDS). My fellowship proposal will determine how dysfunctional B cells contribute towards recurrent pneumonia associated with APDS.</p> <p>I have shown th… more
Amount: £466,653
The role of Eros in Innate and Adaptive Immunity
<p>I will investigate the role of a novel protein, Eros, in immunity. I discovered the fundamental importance of this protein by demonstrating that Eros-deficient mice die from Salmonella infection because their phagocytes cannot make reactive oxygen species. This is because Eros is essential for expression of vital components of the phagocyte NADPH oxidase. My work represents&nbsp;the only paper… more
Amount: £25,000