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Earliest award date
17 Oct 2005
Latest award date
30 Sep 2020
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The Cambridge History of Medicine
This application is for support to develop a proposal for The Cambridge History of Medicine in six volumes. As General Editor, I will meet with a team of a dozen volume editors at a series of workshops to ask fundamental questions about what the history of medicine is, what it should be, and how best to represent it in these books.
Amount: £96,402
Amount: £16,250
Amount: £11,072
Youth, gender and teenage sexual counselling in Britain: The making of the Brook Advisory Centre, 1964-2000
<p>This research uses the history of Brook Advisory Centres (BAC) as a case study through which to reassess the history of teenage sexuality and of the anxieties it caused in postwar Britain. From the first Centre opened in 1964 in London to the present, BAC has been an important provider of contraceptive advice and sexual counselling for unmarried people and teenagers. Although the centres have … more
Amount: £155,453
Darwin Tree of Life
<p>Life has evolved from a single origin to generate &gt;1.5 million eukaryotic species. Sequencing all species will provide an inventory of life, transform understanding of evolution, catalogue eukaryotic gene&nbsp;toolkits for biology and biotechnology, and enable monitoring of ecosystems under increasing stress. The Darwin Tree of Life (DToL) is a new initiative that will exploit long read tec… more
Amount: £264,009
Contribution of transposable elements in cell fate decision
<p>Transposable elements (TEs) are long known to be expressed in different cells during early mammalian development. However, the role of TEs in cellular differentiation has remained elusive. This proposal aims to develop new experimental and computational methods to understand the role of TEs in cellular differentiation. Single cell (sc) RNA sequencing (RNA-seq) has been developed extensively in… more
Amount: £300,000
Mechanisms of epithelial polarity in flies and mammals
<p style="margin-left: 0cm; margin-right: 0cm">AS/A/GCSE-level biology specifications have recently shifted toward an increased focus on practical skills<sup>1</sup>that teachers and schools don&rsquo;t necessarily have the equipment or knowledge to confidently foster across the biology curriculum<sup>2</sup>.&nbsp;The Scientists' Collaborative Project with Educators (SCoPE) is a pilot public eng… more
Amount: £42,756
The Genetic Basis of Congenital Hypothyroidism
<p>I have already identified 2 novel genetic causal variants for congenital hypothyroidism (CH) by whole exome sequencing (WES); IGSF1 defects in central hypothyroidism and SLC26A7 in dyshormonogenetic CH. I will therefore continue this strategy to identify further genetic causes of CH. I will expand my CH cohort, enriched for probability of genetic mutations. After excluding candidate gene defec… more
Amount: £214,297
Vacation Scholarships 2017 - University of Cambridge
<p>Vacation Scholarships 2017 - University of Cambridge</p>
Amount: £21,500
Computational tools for analysing developmental morphogenesis at the tissue-scale
<p>Computational tools for analysing developmental morphogenesis at the tissue-scale</p> <p>&nbsp;</p>
Amount: £47,159
Socio-cultural factors in Zika virus outcomes in Lusophone African countries
<p>What is the research question?<br />1) What social barriers to, and enablers for, effective public health responses/adoption of<br />preventive measures can be identified in health beliefs and practices associated with<br />the Zika virus, with particular attention to variations between countries with different<br />incidence of the disease, socio-demographic groups, and over time? ( WT-DFID<b… more
Amount: £246,252
The biology of acute myeloid leukaemia
<p>Mutations in epigenetic regulators play a pivotal role in leukaemia initiation. We propose to study the most commonly mutated epigenetic regulator in AML: the <em>de </em>novo DNA methyltransferase DNMT3a (25%). It is unclear how DNMT3a mutations subvert HSC, surprisingly in bulk studies differences in methylation do not correlate with differences in gene expression, but somehow DNMT3a mutated… more
Amount: £252,167
Amount: £244,848
Amount: £264,775
Amount: £227,598
Ischia Summer School on the History of the Life Sciences
<p>The Ischia Summer School on the History of the Life Sciences provides advanced training in history of biology and medicine in a historically rich and naturally beautiful setting for 26 PhD students and postdoctoral fellows, with strong UK representation. Lectures and seminars at the Ischia branch of the Naples Zoological Station by nine distinguished international faculty, with student present… more
Amount: £19,960