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The Cambridge History of Medicine
This application is for support to develop a proposal for The Cambridge History of Medicine in six volumes. As General Editor, I will meet with a team of a dozen volume editors at a series of workshops to ask fundamental questions about what the history of medicine is, what it should be, and how best to represent it in these books.
Health, History, and Human Lives in Medieval Cambridge
Principles of human development and germ cell program
<p>Specification of human primordial germ cells (hPGCs) occurs around gastrulation, a critical juncture when the specification of the primary somatic lineages also occurs. In combination with human preimplantation embryos, in<em> vitro</em> models and hPGCs from aborted fetuses, our objective is to elucidate the origin and properties of the early human germline.</p> <p>For the mec… more
Vacation Scholarships 2017 - University of Cambridge
<p>Vacation Scholarships 2017 - University of Cambridge</p>
Infection, Immunity and Inflammation
Mathematical genomics and medicine
Open Access award.
Cambridge Institute for Medical Research (CIMR).
A major objective for CIMR over the next 5 years is to better understand protein localisation, function and metabolism in a range of diseases in which genetic studies have identified the causative genes. Underpinning our core facilities is essential to achieve this objective and will provide added value to the considerable investment that the Wellcome Trust is already making to our scientific ac… more
Stem cell renewal and lineage selection in adult mammalian epidermis.
Adult mammalian epidermis is maintained by stem cells, which self-renew and produce progeny that differentiate along the hair follicle, sebaceous gland and interfollicular epidermal lineages. Two important regulators are Myc and b-catenin. Myc activation causes stem cell depletion and differentiation into interfollicular epidermis and sebaceous gland. b-catenin controls lineage choice in a dose-d… more
CD40 and CD154: breaking and maintaining peripheral tolerance to pancreatic beta cells.
CD40 and CD154: Breaking and maintaining peripheral tolerance to pancreatic beta cells 1. To determine the regulatory capacity of CD40-induced CD4+CD25+ T cells and the role of CD40 in their expansion. 2. To determine the point of divergence between the CD40 and TNFa signalling pathways and how this leads to distinct cellular outcomes. 3. To determine the role of TNFa in the prevention of CD40-induced expansion of CD4+CD25+ T cells.
Collaborations between developing and developed countries in advancing biomedical population genetics, neglected diseases and bioprospecting R&D: developing policy and practice guidelines for going forward in 21st century.
Studentship in Biomedical Ethics Project title: Collaborations between developing and developed countries in advancing biomedical population genetics, neglected diseases and bioprospecting R&D: Developing Policy and Practice Guidelines for Going Forward in the 21st century. The project will examine the structure, organisation and interplay of key ethical, socio-economic, health-policy and comm… more
Fundamental associative learning processes in psychosis: combined behavioural, functional neuroimaging and psychopharmacological studies.
Delusions are core symptoms of psychotic illnesses such as schizophrenia. Central to our understanding of delusions is the idea that they emerge from a background of abnormal formation of associations. Over the last decade, there has been an increasing understanding of the neuroscience of association formation. This work has emphasised prediction error signal as a drive to associative learning an… more
21st Century Families: Parent-child relationships and children's psychological wellbeing
<p>New pathways to parenthood have recently emerged that did not exist, nor had even been imagined, at the turn of the 21<sup>st</sup> century. Individuals who were previously unknown to each other have begun to meet over the internet with the purpose of having children together; transgender men and women have begun to have children through medically assisted reproduction; single heterosexual men… more
Genetic and functional interactions in the mammalian DNA-damage response
<p>DNA in our cells is frequently subject to a wide array of molecularly-distinct forms of damage. To cope with this, life has evolved multiple DNA repair and associated processes, collectively termed the DNA-damage response (DDR). While considerable progress has been made in identifying DDR proteins and their regulators, much remains to be learned about how they operate and are controlled. Build… more
The cognitive neuroscience of over-eating: normative and clinical studies of goal-driven and stimulus-driven responses
<p>There is a pressing need to understand the phenotypic variations of obesity in order to elucidate the diverse pathways and mechanisms by which it arises and, ultimately, to offer suitably tailored interventions. My proposed work aims to provide insights into the cognitive neuroscience of health-harming over-consumption. Its ultimate goals are to characterise cognitive mechanisms underlyi… more
Understanding mammalian interphase genome structure in mouse ES cells
<p>The folding of genomic DNA from the beads-on-a-string like structure of nucleosomes into higher order assemblies is critically linked to nuclear processes, but it is unclear to what degree it is a cause or consequence of function. We aim to understand whether the Nucleosome Remodeling and Deacetylation (NuRD) complex regulates chromatin structure to control transcription, or whether it is NuRD… more
Molecular mechanisms controlling germline stem cell biology
<p>The ability of stem cells to replenish and differentiate is critical for tissue growth, repair, and homeostasis. Yet, our understanding of the molecular mechanisms governing stem cell fate transitions remains limited. Through a systematic RNAi screen using the Drosophila germline as a model for stem cell biology, I uncovered a central role for ribosome biogenesis and protein synthesis regulati… more
Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity
<p>Intestinal infections affect billions of people worldwide, resulting in nearly 1.4 million deaths each year. The commensal microbiota can prevent pathogenic infection, as demonstrated by increased susceptibility to infection upon antibiotic use; however, the precise mechanisms of microbiota-mediated protection are not well-characterized. I have recently discovered that colonization of mice wit… more