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Search results (Displaying 95 grants)

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Earliest award date
18 Jan 2013
Latest award date
30 Sep 2020
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The Cambridge History of Medicine
This application is for support to develop a proposal for The Cambridge History of Medicine in six volumes. As General Editor, I will meet with a team of a dozen volume editors at a series of workshops to ask fundamental questions about what the history of medicine is, what it should be, and how best to represent it in these books.
Amount: £96,402
Principles of human development and germ cell program
<p>Specification of human primordial germ cells (hPGCs)&nbsp;occurs around gastrulation, a critical juncture when the specification of the primary somatic lineages&nbsp;also occurs. In combination with human preimplantation embryos, in<em> vitro</em> models and hPGCs from aborted fetuses, our objective is to elucidate the origin and properties of the early human germline.</p> <p>For&nbsp;the mec… more
Amount: £2,750,000
Vacation Scholarships 2017 - University of Cambridge
<p>Vacation Scholarships 2017 - University of Cambridge</p>
Amount: £21,500
Amount: £2,750,000
Amount: £2,610,000
Amount: £2,490,000
Genome diversity and evolution in transmissible cancers in dogs and tasmanian devils
Tasmanian devil facial tumour disease and canine transmissible venereal tumour are the only two known naturally occurring clonally transmissible cancers. The goal of this project is to catalogue the genetic and phenotypic diversity captured in geographically dispersed populations of DFTD and CTVT.
Amount: £1,167,505
The impact of murine norovirus infection on the innate immune system.
<table> <tbody> <tr> <td>We &nbsp; propose that the activation of innate immune responses become altered upon &nbsp; infection with persistent versus non-persistent strains of MNV. We further &nbsp; propose that persistent MNV infection affects subsequent immune responses to &nbsp; other pathogens such as Salmonella. 1. To identify the signaling pathways of &nbsp; the innate immune system involve… more
Amount: £18,300
MH Master's
Not available
Amount: £22,345
Defining the mechanisms of induced pluripotency.
My research has centred on nuclear reprogramming since my PhD. As an independent Principal Investigator I have developed unique systems to better investigate the process of induced pluripotency. This resulted in the identification of Nanog and culture environment as key players and has helped re-define our understanding of the biological roles of Oct4. As a senior principal investigator I want to… more
Amount: £1,861,906
Fragment-based lead discovery against the protein-protein interaction between Aurora A and TPX2 for the treatment of cancer
The Wellcome Trust has awarded over £2.3 million to Chris Abell, John Skidmore and co-workers at the University of Cambridge to use fragment-based approaches for the generation of molecules which disrupt the interaction between the kinase Aurora A and the regulatory protein TPX2. Such compounds are expected to have utility in the treatment of a number of solid and haematological cancers, with one… more
Amount: £1,177,025
Mutational signatures of DNA damage and repair processes.
DNA in all cells is prone to mutagenesis, with somatic mutations making key contributions to human diseases such as cancer and neurodegenerative diseases, and to aging itself. Mutations are the consequence of exogenous or endogenous mutagenic influences (including radiations and DNA-damaging chemicals) and also result from enzymatic DNA modifications or low fidelity DNA synthesis by specialized D… more
Amount: £1,027,551
Dissecting the mechanisms of metaboregulatory thermogenesis
The recent discovery of brown adipose tissue (BAT) in adult humans makes possible a new therapeutic approach to treat obesity, by activating endogenous BAT or making white adipose tissue more like BAT. To understand how to achieve these aims, physiological activation of BAT must be understood. Whiles much is known about thermoregulatory thermogenesis, the neuronal networks regulating metabregulat… more
Amount: £10,818
Defining the mechanisms by which maternal diet-induced obesity programmes central control of palatable food intake
In light of growing evidence for a transgenerational component in the current human obesity epidemic, it is important to understand how maternal environment affects the long-term health of the developing foetus. In animal models, maternal over-nutrition has been shown to programme a metabolic syndrome-like phenotype and hyperphagia in the offspring. In this project, we propose to use anestablishe… more
Amount: £42,734
21st Century Families: Parent-child relationships and children's psychological wellbeing
<p>New pathways to parenthood have recently emerged that did not exist, nor had even been imagined, at the turn of the 21<sup>st</sup> century. Individuals who were previously unknown to each other have begun to meet over the internet with the purpose of having children together; transgender men and women have begun to have children through medically assisted reproduction; single heterosexual men… more
Amount: £1,552,401
Genetic and functional interactions in the mammalian DNA-damage response
<p>DNA in our cells is frequently subject to a wide array of molecularly-distinct forms of damage. To cope with this, life has evolved multiple DNA repair and associated processes, collectively termed the DNA-damage response (DDR). While considerable progress has been made in identifying DDR proteins and their regulators, much remains to be learned about how they operate and are controlled. Build… more
Amount: £1,636,331
The cognitive neuroscience of over-eating: normative and clinical studies of goal-driven and stimulus-driven responses
<p>There is a pressing need to understand the phenotypic variations of obesity in order to elucidate the diverse pathways and mechanisms by which it arises and, ultimately, to offer suitably tailored interventions. My proposed work aims to provide insights into the cognitive neuroscience of health-harming over-consumption.&nbsp; Its ultimate goals are to characterise cognitive mechanisms underlyi… more
Amount: £1,500,053
Understanding mammalian interphase genome structure in mouse ES cells
<p>The folding of genomic DNA from the beads-on-a-string like structure of nucleosomes into higher order assemblies is critically linked to nuclear processes, but it is unclear to what degree it is a cause or consequence of function. We aim to understand whether the Nucleosome Remodeling and Deacetylation (NuRD) complex regulates chromatin structure to control transcription, or whether it is NuRD… more
Amount: £2,031,409