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The Cambridge History of Medicine
This application is for support to develop a proposal for The Cambridge History of Medicine in six volumes. As General Editor, I will meet with a team of a dozen volume editors at a series of workshops to ask fundamental questions about what the history of medicine is, what it should be, and how best to represent it in these books.
Health, History, and Human Lives in Medieval Cambridge
Principles of human development and germ cell program
<p>Specification of human primordial germ cells (hPGCs) occurs around gastrulation, a critical juncture when the specification of the primary somatic lineages also occurs. In combination with human preimplantation embryos, in<em> vitro</em> models and hPGCs from aborted fetuses, our objective is to elucidate the origin and properties of the early human germline.</p> <p>For the mec… more
Vacation Scholarships 2017 - University of Cambridge
<p>Vacation Scholarships 2017 - University of Cambridge</p>
Infection, Immunity and Inflammation
Mathematical genomics and medicine
A new approach to OCD: assessing the impact of environmental stimuli on functional and dysfunctional checking behaviour.
<p>Obsessive-compulsive disorder (OCD) is a common and highly debilitating mental health disorder, which could be potentially treated through the disruption of maladaptive memories that contribute to the persistence of the disorder. Using an instrumental rodent model of OCD, the Observing Response Task (ORT), in which animals are trained to make unpredictably reinforced instrumental responses, bu… more
The role of leukocyte, platelet and endothelial cell interactions in chemotherapy-induced venous thromboembolism
<p><strong>Venous thromboembolism</strong> (VTE) is a life-threatening complication of cancer. Cancer patients undergoing chemotherapy are at increased risk of VTE, but the lack of <em>in vitro</em> models of VTE development has made it difficult to study the complex cell interactions involved in detail. Understanding the mechanisms that lead to VTE is the first step in designing safer anti-cance… more
Comparative studies to understand the role of class II molecules expressed in epithelial cells.
<p><em>Molecules of the major histocompatibility complex (MHC) are crucial for many immune responses, presenting antigenic fragments (usually peptides) to T lymphocytes of the adaptive immune system, as well as being recognised by natural killer cells, myeloid cells and others as part of the innate immune system. Despite decades of research by many thousands of researchers, there is still much to… more
MPhil in History and Philosophy of Science and Medicine.
Biomedical Vacation Scholarship
Investigating the interplay between CTCF haploinsufficiency and DNA stability using high-throughput approaches in genetic and chemical models of carcinogenesis.
Mitochondrial regulation of inflammation in atherosclerosis.
<p>Recent collaborative work demonstrated that mitochondrial DNA (mtDNA) damage and mitochondrial dysfunction occur early in atherosclerosis and that they are linked to vascular smooth muscle cell (VSMC) senescence and cell death as well as pro-inflammatory signalling through monocytes. Importantly, mitochondrial DNA damage is also correlated with atherosclerosis and features of plaque vulnerabil… more
The host response to Staphylococcus aureus infection.
How is the host response to Staphylococcus aureus orchestrated? How does S. aureus trigger release of nerve growth factor (NGF) from host cells? How does NGF trigger host effector immunity to S. aureus?
Noise in neural codes: consequences for memory, exploration and decision-making.
Working memory (WM) refers to the nervous system's capacity to internally maintain information about the external world over short periods, and manipulate that information in support of behaviour. WM is considered fundamental to many if not all cognitive functions, and its impairment by age or disease has far-reaching consequences for human health and well-being. This research programme aims to u… more
Resolving early mesodermal fate decisions at the single cell level to identify differentiation pathways and novel regulators.
<p>Human development progresses from a single fertilised egg to a multicellular organism composed of cells highly-organised into functional units called organs. All the various cells are generated from the same precursor and the processes by which the different cell types emerge is poorly understood. The chromatin structure, transcriptome and proteome may uniquely de… more
Fragment-based lead discovery against the protein-protein interaction between Aurora A and TPX2 for the treatment of cancer
The Wellcome Trust has awarded over £2.3 million to Chris Abell, John Skidmore and co-workers at the University of Cambridge to use fragment-based approaches for the generation of molecules which disrupt the interaction between the kinase Aurora A and the regulatory protein TPX2. Such compounds are expected to have utility in the treatment of a number of solid and haematological cancers, with on… more
Cambridge Stem Cell Institute Four year PhD studentships - Stem Cell Biology - Sarah Foerster
<p>This proposal is to facilitate creation of a world-leading centre for fundamental and translational stem cell research. The Cambridge Stem Cell Institute (SCI) will build upon previous Wellcome Trust and Medical Research Council funding by drawing together 30 research teams into a cohesive centre. These groups will ultimately be co-located in a purpose-designed 8000m2 facility to be constructe… more