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Earliest award date
31 Jan 2017
Latest award date
30 Sep 2020
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The Cambridge History of Medicine
This application is for support to develop a proposal for The Cambridge History of Medicine in six volumes. As General Editor, I will meet with a team of a dozen volume editors at a series of workshops to ask fundamental questions about what the history of medicine is, what it should be, and how best to represent it in these books.
Amount: £96,402
Vacation Scholarships 2017 - University of Cambridge
<p>Vacation Scholarships 2017 - University of Cambridge</p>
Amount: £21,500
Dynamic neural remapping across the sleep-wake cycle: A mechanistic link between sensory re-organisation and GABA
<p>Across a single day, we undergo behavioral, physiological and neurochemical changes, from vigilant wakefulness to unconscious sleep. Despite the loss of consciousness, sensory processing continues in sleep. Attempts to assess the degree to which sensory processing differs between wakefulness and sleep have yielded contradicting results with studies showing greater, smaller or comparable respon… more
Amount: £99,935
Master's Award in Humanities and Social Science
<p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;In my three essays, I will explore case studies of British biotechnology and bioethics since the 1960s. My first essay will investigate the history of organ donation regulation in the UK by focusing on two pieces of legislation: the Human Tissue Act of 1961 and the Human Organ Transplants Act of 1989, which aimed to regulate the procurement of cad… more
Amount: £28,440
Exploring Disorganised Attachment: Unravelling Developmental Pathways and Outcomes using Data Mining
<p>Disorganised attachment is an important assessment of infant mental health, introduced by Main and Solomon (1990). Disorganisation is thought to result from an infant having in some way experienced trauma within the context of the relationship with their caregiver (e.g. observing severe domestic violence). Infants classified as disorganised have an&nbsp;elevated risk of psychological problems,… more
Amount: £25,976
Amulets and the material culture of healing
<p>The goal of this project is to investigate how amulets represent varying forms of value and power across differing chronologies. The Science Museum's collection will allow me to comprehensively examine a diverse range of objects, and research different forms of medical, magical and scientific worth and potency unavailable by studying textual sources alone. This project will ask three questions… more
Amount: £15,523
Attachment and the transgenerational effects of loss, abuse and trauma: Exploring and testing classic ideas through historical analysis and developmental science
<p>Since it was introduced by John Bowlby, attachment research has been among the most influential paradigms for understanding the social underpinnings of infant mental health and transgenerational mental health. However, an odd artefact of the way a major research instrument was constructed in the 1980s by Mary Main has meant that to date attachment research has largely treated loss, abuse, and … more
Amount: £97,935
Fundamental mechanisms controlling human energy homeostasis
<p>Obesity and associated diseases such as type 2 diabetes, cardiovascular disease and some cancers represent a significant health burden. My overall aim is to identify new therapeutic strategies for severe obesity. Using extensive genetic and clinical data on unique cohorts of individuals at both extremes of the weight distribution (severe obesity and thinness), we will comprehensively map the m… more
Amount: £50,000
Visualizing Citizen Voice in a Moment of 'Big Data'
<p>Visualizing Citizen Voice in a Moment of 'Big Data'</p>
Amount: £21,350
The role of Eros in Innate and Adaptive Immunity
<p>I will investigate the role of a novel protein, Eros, in immunity. I discovered the fundamental importance of this protein by demonstrating that Eros-deficient mice die from Salmonella infection because their phagocytes cannot make reactive oxygen species. This is because Eros is essential for expression of vital components of the phagocyte NADPH oxidase. My work represents&nbsp;the only paper… more
Amount: £25,000
Human Pluripotent Stem Cell-Derived Brown/Beige Adipocyte Models: Investigating Thermogenic Adipocyte Development and Function
<p>Brown adipose tissue (BAT) is responsible for non-shivering thermogenesis and controls energy balance. With the discovery that human adults have functional BAT, the activity of which correlates with decreased BMI and increased energy expenditure, the ability to target BAT through increasing i) BAT mass, ii) BAT activity, or iii) white adipose tissue (WAT) browning, has emerged as a potential t… more
Amount: £40,980
Developmental Programming of Cardiovascular Dysfunction by Chronic Intermittent Hypoxia
<p>Cardiovascular disease remains the greatest killer in the world. The environment encountered in fetal life can exert a profound influence on an individual&rsquo;s risk of cardiovascular disease; what is known as developmental programming. Understanding the mechanisms via which programming occurs may lead to preventative therapy. One common outcomes of complicated pregnancy is fetal exposure to… more
Amount: £60,318
Investigating How Epithelial-Endothelial Interactions Regulate Epithelial Cell Fate And Morphogenesis in Human Lung Development
<p>The mammalian lung has a complex tree-like epithelial structure tightly intertwined with vascular vessels. Endothelial cells, which line vascular vessels, have been reported to play an instructive role in maintaining tissue-specific stem cells and regulating regeneration. However, how endothelial-epithelial crosstalk functions in lung development, especially in alveolar cell fate specification… more
Amount: £37,985
Microtubule organisation in developing neurons
<p>Microtubule (MT) bundles found in neuronal axons are highly organised, as around 90% of MTs point with their growing end (commonly referred to as the +end) away from the cell body. This MT orientation is crucial for correct cargo localisation. Known for more than 30 years, the underlying mechanisms for axonal MT organisation are yet to be discovered. Preliminary experimental data from the Fran… more
Amount: £14,678
Quantitative visualization of polarity protein complexes in Drosophila and mouse polarized epithelia
<p>Epithelial cells have to establish and maintain apicobasal polarity to perform their vectorial secretory and absorptive functions. At the cellular level, polarity is defined by apical, lateral and basal domains, each marked by distinct polarity proteins localized at the cell cortex and in the cytoplasm. Based on biochemical and genetic evidence from C. elegans, D. melanogaster and cultured mam… more
Amount: £21,342
Development and leptin signalling in human stem cell-derived POMC neurons
<p>Energy homeostasis in mammals is tightly controlled by a distinct neural circuit in the hypothalamus and its dysfunction leads to obesity. Pro-opiomelanocortin (POMC) neurons are a central component of this circuit. While obesity research has been largely limited to studies in rodents in the past decades, recently published protocols now allow the<em> in vitro</em> generation of human POMC neu… more
Amount: £46,168
Investigating the Impact of Extrinsic Factors on Intestinal Stem Cell Dynamics
<p>The rapid turnover of the mammalian intestinal epithelium is fuelled by division of stem cells residing at the bottom of the crypts of Lieberk&uuml;hn. Our understanding of how stem cells populate the intestine in humans lags behind that of the murine system. In the latter, stem cells populate the crypts by a process of neutral drift. Moreover the number of functional stem cells per crypt and … more
Amount: £46,765
The role and regulation of UHRF1 during epigenetic reprogramming
<p>During both mouse and human embryonic development there are two waves of global DNA demethylation associated with an increase in developmental potential: firstly during the development of the inner cell mass from the gametes, and secondly during the development of primordial germ cells. Although some of these changes in DNA methylation are correlated with gene expression, it is not understood … more
Amount: £26,820
Dynamic interplay between the ageing CNS progenitor cells and their surrounding niche
<p>The pathological loss of myelin sheath from axons predisposes neurons to atrophy and subsequent death. In response to brain demyelination, a cell population called oligodendrocyte progenitor cells (OPCs) proliferate and differentiate into oligodendrocytes (OLs), which remyelinate exposed axons. In ageing remyelination often fails due to a reduction in OPC regenerative capacity.&nbsp;The age-re… more
Amount: £62,117