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Search results (Displaying 1,271 grants)

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Earliest award date
17 Oct 2005
Latest award date
30 Sep 2020
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Chloroquine/Hydroxychloroquine prevention of coronavirus disease (COVID-19) in the healthcare setting; a randomised, placebo-controlled prophylaxis study (COPCOV)
There is no proven treatment, chemoprophylaxis or vaccine for COVID-19. This is the most serious pandemic emergency for 100 years. Healthcare workers are being affected disproportionately in the continuing epidemic threatening an imminent breakdown of health services. Chloroquine and hydroxychloroquine are safe and well-tolerated medications which can be taken for years without adverse effects.Bo… more
Amount: £6,920,135
Amount: £200,000
Amount: £1,157,238
Human sensitivity to short-wavelength light in non-image-forming vision: Toward a mechanistic understanding of the impact of blue light on sleep and circadian rhythms
<p>In chronobiology and sleep research, a significant proportion of past research studies examining the effects of light on the acute suppression of melatonin and on circadian photoentrainment have exclusively examined male participants, or naturally cycling female participants. The basis for this bias in participant recruitment is empirical evidence that the production of melatonin may be modula… more
Amount: £20,000
Function of novel human T cell subsets in host defence
<p>We are organising an international meeting on unconventional T cells (CD1-MR1: beyond MHC restricted lymphocytes). This is the major meeting for groups investigating these important components of immunity and occurs every 2 years, lasting 4 days. The aim of this proposal is to help support initiatives within this meeting to enhance diversity and inclusion. These include: Bursaries for those wi… more
Amount: £19,000
In Their Own Voices: Vulnerabilities & Abilities of Women, Children, & Families in Health Research
<p>As REACH enters its second year, we have an exciting opportunity to use our early findings and to expand our use of visual methods to spark wider community and public debate about the ethical issues arising in research with women, children&nbsp;and their families in contexts of poverty and gender inequality. This proposal complements existing Africa and Asia Programme provisions for public eng… more
Amount: £140,079
Amount: £150,000
Amount: £11,000
An Extended Pilot for the Human Cell Atlas: Adult tissues, human development and inflammation-mediated pathologies
<p>The Human Cell Atlas (HCA) is an international, collaborative effort that &ldquo;&hellip;aims to define all human cell types in terms of their distinctive patterns of gene expression, physiological states, developmental trajectories, and location&rdquo;.</p> <p>&nbsp;</p> <p>Here, we will contribute directly to the first phase of the HCA by forming an &lsquo;extended pilot&rsquo; to implemen… more
Amount: £389,335
Flexible task representations for intelligent behavior
<p>A long research tradition in cognitive neuroscience has investigated the role of the prefrontal cortex (PFC) in flexible goal-directed behaviour. This work has yielded important insights, e.g., that the PFC&rsquo;s coding properties flexibly adapt when task demands change&nbsp;to prioritise goal-relevant information. However,&nbsp;it relies primarily upon the use&nbsp;of familiar and explicitl… more
Amount: £250,000
Metabolic Characterization of Natural Killer T Cell responses to sterile, hypoxic injury
<p>It has been described that&nbsp;ischemia-reperfusion injury (IRI), such as during&nbsp;organ transplantation,&nbsp;evokes damaging sterile inflammation and secondary tissue injury that is&nbsp;dependent on iNKT cell activation, but the underlying mechanisms remain elusive.&nbsp;Similarly, in sickle cell disease (SCD)&nbsp;mice,&nbsp;RBC sickling and widely disseminated microvascular ischemia&n… more
Amount: £250,000
CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Amount: £21,120
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Amount: £22,186
Mesh Community Engagement Network
<p>Mesh Community Engagement Network (<u>www.mesh-ce.org</u>) is a collaborative open-access webspace and networking project for people involved in community&nbsp;engagement with global health research (CE). Building on a successful pilot, we propose a new three-year strategic approach with a&nbsp;focus on measuring impact, using a <em>Theory of Change</em>&nbsp;to provide clarity on how we expec… more
Amount: £243,993
Amount: £12,456
Global Environmental (in)Activism: a Multi-sited Ethnography of Industrial Pollution, Illness and Community Resistance in Italy and Taiwan
<p>The research proposed is a multi-sited ethnographic investigation into the relationship between industrial pollution as a health threat and the ongoing social, political, and moral struggle of two communities living in close proximity to polluting sites. Through a comparative study of the people of Taranto, Italy, and Tainan, Taiwan, this project seeks to explore the political dimensions of en… more
Amount: £141,231
Amount: £100,000
<p style="margin-left: 0cm; margin-right: 0cm">The International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) is a federation of clinical research networks&nbsp;whose aim is to prevent illness and deaths from infectious diseases outbreaks. This aim is supported by two key objectives: (i) To generate and disseminate clinical research evidence for outbreak-prone infectious d… more
Amount: £3,099,568
Amount: £1,171,479