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- 17 Oct 2005
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- 14 Dec 2005
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Molecular and behavioural characterisation of mice over-expressing type 1 neuregulin-1.
Molecular and behavioural characterisation of mice over-expressing type I neuregulin-1 Neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia, and increased expression of the NRG1 type 1 isoform occurs in the disease. The main aim of this study is to establish the extent to which overexpression of type 1 NRG1 in mice reproduces molecular, morphological, and behavioural features of schizo… more
Functional significance of haplotype-specific variations in MAPT and their potential role in the pathogenesis of neurodegenerative disease.
Functional significance of haplotype-specific sequence variations in MAPT and their potential role in the pathogenesis of neurodegenerative disease With a rapidly ageing population in many developed countries, the study of neurodegenerative illness and dementia is becoming increasingly important. A whole range of neurodegenerative diseases, collectively referred to as tauopathies, is characteris… more
Genetic mechanisms in congenital heart disease.
We hypothesise that mutations in left-right patterning genes are responsible for a substantial proportion of human congenital heart disease that are not usually considered to be left-right patterning defects. Cited2 null mice indicate that common congenital heart disease can arise as hypomorphs or form frustes of an underlying left-right patterning defect. Human studies have recently shown that p… more
Dissecting the role of nucleo-mitochondrial interactions in mtDNA diseases.
The key goals are to identify and characterise nucleo-mitochondrial interactions that are important in mtDNA diseases. Mitochondrial proteins encoded by nuclear DNA which interact directly or indirectly with mitochondrial DNA (mtDNA) can cause defects in mtDNA maintenance in both humans and yeast. MtDNA depletion syndrome (MDS) is one such severe disorder,affecting liver and muscle. MDS demonstra… more
Testicular function in mice lacking sertoli cell androgen receptors and FSH receptors.
Testicular differentiation, development and adult function are critically dependent on the Sertoli cells. These cells line the seminiferous tubules and regulate and support germ cell proliferation and differentiation. While it is known that Sertoli cells and spermatogenesis are regulated by follicle stimulating hormone (FSH) and androgen, the relative contribution of each hormone to Sertoli cell … more
Premotor networks in the human brain: anatomy, physiology and modulation in disease.
This project aims to develop novel neurorehabilitation strategies to promote motor recovery after stroke. It is focused on the human premotor cortex (PMC), a region shown to be critically involved in recovery of movement ability after stroke. I propose to study the anatomy, physiology and functional connectivity of PMC circuits in the healthy human brain, to test for changes in these circuits aft… more
Corticostriatal control over hippocampal and amygdala-dependent appetitive learning and memory systems.
There is growing evidence that multiple, interactive learning and memory systems provide the basis of behaviour, and that disruptions or imbalances within these systems result in the manifestation of abnormal behaviour. Considerable effort is currently being directed at characterising the key neural structures comprising these systems, and this project will investigate the neural and neurochemica… more
Initiation and impact of conjugative transfer by antibiotic resistant haemophilus element.
The spread of antibiotic resistance is a major threat to the continued successof medicine. By studying the evolution and properties of antibiotic resistancein Haemophilus influenzae, which arises from the successful spread of a singlefamily of conjugating and integrating elements (ICEs) world wide, an explanatory model is possible. Furthermore, these ICEs are evolutionarily related to a number of… more
Stimulus-timing-dependent plasticity in the auditory cortex.
Stimulus-timing-dependent plasticity in ferret auditory cortex Adult cortical circuits possess considerable plasticity, which can be induced by modifying their inputs. In the visual system, repetitive pairing of stimuli of different orientations or at different spatial locations leads to changes in the receptive field properties of cortical neurons and in human perception, the nature of which dep… more