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Your search ‘’ returned 69 results in ‘All grant fields’

Search results (Displaying 69 grants)

Total grants
69
Total funders
1
Total recipients
1
Earliest award date
27 Jan 2012
Latest award date
18 Dec 2012
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Amount: £400,000
Psychology and the Special Operations Executive, 1940-46: The Selection of Clandestine Operatives and the Treatment of Survivors.
Set up in 1940 and disbanded in 1946, the Special Operations Executive (SOE) was a clandestine Allied organisation tasked during the Second World War with carrying out sabotage behind enemy lines and encouraging occupied populations to resist. By the end of the war it had recruited and trained more than 9,000 operatives who were expected to endure, for long periods, conditions of extreme physical… more
Amount: £144,406
Sub-millimetre structural connectivity imaging of cortical, subcortical and spinal pathways in humans.
I will enable sub-millimetre diffusion magnetic resonance imaging (dMRI) by developing two techniques designed to take advantage of the benefits of high-field MRI (7 Tesla). First, I will develop the second generation of simultaneous multi-slice imaging for high-field based on my recent PINS radio-frequency (RF) pulse technology[21-23]. Second, I will tailor parallel RF transmission techniques f… more
Amount: £250,000
The study of immune cell development by stem cell mutagenesis.
This proposal applies embryonic stem cell mutagenesis in vitro, and somatic mutagenesis of hematopoietic stem cells in vivo, to understand pathways of immune cell differentiation. The first approach involves the creation of recessive mutations in mouse haploid embryonic stem cells, which will then be differentiated into myeloid and lymphoid cells in vitro. A second complementary approach involves… more
Amount: £250,000
Human to mosquito transmission of dengue virsues and Wolbachia-mediated interference of vector competence
This research training fellowship will identify immunological and virological correlates of human-tomosquito dengue virus transmission. I will do this using a combination of clinical studies (direct exposure of mosquitoes to viremic humans), immunological measurements of the antibody response and virological assessments of the viral load in the patients blood and also in the mosquito. This fellow… more
Amount: £204,593
Efficacy of mobile phone short message service (SMS) on malaria treatment adherence and post-treatment review.
<p>Artemisinin resistant falciparum malaria has emerged in south East Asia (SEA), an ominous repetition of the spread of<br />chloroquine and later of sulfadoxine-pyrimethamine resistance, several decades ago. Recent evidence suggests<br />artemisinin resistance foci in Western Cambodia, Western Thailand, and Burma. This poses a major global public health<br />threat, with the greatest potential … more
Amount: £212,516
Wellcome Trust Clinical PhD Programme at the University of Oxford: Redox regulation of protein phosphorylayion in the fibrillating atrial myocardium.
<p>Atrial fibrillation (AF) is the most common, sustained, cardiac arrhythmia and is a significant cause of stroke and heart failure. The pathogenesis of the condition is poorly understood, but it is known to be associated with remodelling of the electrophysiological properties and structure of the atrial myocardium. Evidence indicates that at least some of the changes in ion currents and transpo… more
Amount: £251,319
Wellcome Trust Clinical PhD Programme at the University of Oxford: How does memory inflation occur? Analysis using novel adenovirus constructs.
<p>The&nbsp; research&nbsp; is&nbsp; aimed&nbsp; at&nbsp; a&nbsp; basic&nbsp; immunologic&nbsp; question&nbsp; highlighted&nbsp; through&nbsp; murine&nbsp; cytomegalovirus (MCMV)&nbsp; infection, which is&nbsp; how&nbsp; does&nbsp; memory&nbsp; "inflation" occur?&nbsp;&nbsp;&nbsp; In other words, what are the basic molecular and cellular components that are required in order to generate sustained… more
Amount: £219,709
How does memory inflation occur? Analysis using novel adenovirus constructs
<p>The&nbsp; research&nbsp; is&nbsp; aimed&nbsp; at&nbsp; a&nbsp; basic&nbsp; immunologic&nbsp; question&nbsp; highlighted&nbsp; through&nbsp; murine&nbsp; cytomegalovirus (MCMV)&nbsp; infection, which is&nbsp; how&nbsp; does&nbsp; memory&nbsp; "inflation" occur?&nbsp;&nbsp;&nbsp; In other words, what are the basic molecular and cellular components that are required in order to generate sustained… more
Amount: £29,530
Wellcome Trust Clinical PhD Programme at the University of Oxford: The role of the Adapter Protein 2 sigma subunit (AP2S1) in calcium homeostasis
<p><span style="color: #62645b; font-family: Arial; font-size: medium;"><span style="color: #62645b; font-family: Arial; font-size: medium;"><span style="color: #62645b; font-family: Arial; font-size: medium;"></span></span></span></p> <p>G-protein&nbsp; coupled receptors&nbsp; (GPCRs) play&nbsp; a central&nbsp; role&nbsp; in facilitating&nbsp; cellular responses&nbsp; to diverse extracellular st… more
Amount: £249,480
Wellcome Trust Clinical PhD Programme at the University of Oxford: The role of HIF prolyl hydroxylase enzymes in ventilatory acclimatisation to hypoxia
<p>Mechanisms underlying ventilatory acclimatization to sustained hypoxia are poorly understood, but could represent therapeutic targets for treatment of diseases characterized by hypoxaemia and breathlessness, including acute altitude sickness. The Ratcliffe laboratory specializes in the biology of Hypoxia Induced Factor (HIF), which co- ordinates the transcriptional response to hypoxia and is r… more
Amount: £255,404
Cortical mechanisms underlying human behavioural control.
Our brains devote substantial resources towards making profitable choices by often selecting courses of actions with high value, and seldom those with low value. The orbitofrontal cortex has been shown to represent an internal model of the world that allows it to make precise associations between stimuli and rewards and to flexibly guide a goal-oriented behaviour. The hippocampus also has a model… more
Amount: £159,340
Amount: £22,680
Investigation of signal integration by non-catalytic tyrosine phosphorylated receptors in leukocytes
This work will investigate signal integration in cells through analysis of non-catalytic tyrosine-phosphorylated receptors (NTRs). NTRs are a recently described group of leukocyte cell-surface receptors [1, 2] that share a numberof features, including: i) they contain, or associate with adaptor molecules that contain, tyrosine residues that are phosphorylated by extrinsic kinases such as Lck; ii)… more
Amount: £159,340
The temporal dynamics of visual selection: convergence from lesion-symptom mapping and the intact functioning brain.
Visual attention refers to the cognitive process of selecting goal-relevant information while ignoring irrelevant information. Many neuroimaging studies have been devoted to localise with high precision the brain areas involved in visual attention, suggesting that visual attention is an emerging property from a network of brain areas, including different areas in the parietal lobe. However, less … more
Amount: £250,000
Jointly modelling phenotype and function in the fine-mapping and follow-up of disease associated loci.
I will develop a statistical model to be applied to association data across multiple traits (be they end-stage disease phenotypes, intermediate phenotypes, or measures of molecular function). This model will explicitly account for the genetic relationship between traits, and will provide estimates and uncertainty information for important questions, such as which traits are affected by a given va… more
Amount: £250,000
Investigation of the role of B cells and the tolerance signature in cutaneous squamous cell carcinoma in renal transplant recipients.
Transplantation is the only long term solution for organ failure, but requires lifelong immunosuppression. Kidney transplant recipients (KTR) are at significantly higher risk of malignancy, in particular cutaneous squamous cell carcinoma (SCC). A previous study by this group demonstrated that KTRs who develop multiple SCCs have a distinct immune phenotype, characterised by increased levels of r… more
Amount: £211,275
Decoding the influenza A virus polymerase-promoter complex
RNA viruses are masters at encoding an extraordinary number of functions in a relatively limited amount of genomic space. To achieve this, they densely integrate functions or employ functional components for multiple purposes. An elegant example is the RNA promoter that flanks all genes encoded by influenza A virus, an RNA virus that is a significant threat to our health and economy. Although the… more
Amount: £250,000
Amount: £40,000
Amount: £15,000