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Human sensitivity to short-wavelength light in non-image-forming vision: Toward a mechanistic understanding of the impact of blue light on sleep and circadian rhythms
<p>In chronobiology and sleep research, a significant proportion of past research studies examining the effects of light on the acute suppression of melatonin and on circadian photoentrainment have exclusively examined male participants, or naturally cycling female participants. The basis for this bias in participant recruitment is empirical evidence that the production of melatonin may be modula… more
Function of novel human T cell subsets in host defence
<p>We are organising an international meeting on unconventional T cells (CD1-MR1: beyond MHC restricted lymphocytes). This is the major meeting for groups investigating these important components of immunity and occurs every 2 years, lasting 4 days. The aim of this proposal is to help support initiatives within this meeting to enhance diversity and inclusion. These include: Bursaries for those wi… more
Vacation Scholarships 2018 - University of Oxford
CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Vacation Scholarships 2019 - University of Oxford
Structural studies of the host-parasite interactions at the heart of malaria pathogenicity
<p>Our proposed activities consist of two major strands.</p> <p> </p> <p>Firstly we wish to take our research on tour, developing a high quality interactive stall which will allow us to present our findings to those who visit science fairs. We have secured a place at the Royal Society Summer Science Exhibition in July 2018, as the first outing for our display and this provides the deadline… more
<p>'Sacred Water' – an engagement project run by artist Lena Bui, was a creative space for researchers at OUCRU-Nepal and people living in the Kathmandu Valley to discuss health with a focus on water. However, the earthquake of 2015 caused many participants to reflect on a wider view of health. Lena became interested in what people turn to for a sense of wellbeing - cultural… more
Vacation Scholarships 2017 - University of Oxford
<p>Vacation Scholarships 2017-University of Oxford</p>
Defining host and viral factors that are associated with hepatitis B virus control and clearance in Caucasian and African adults.
HBV accounts for a significant global burden of liver disease. This project is founded on the urgent need to characterise T cell responses in order to enhance our understanding of differential outcomes of infection, and underpin future immunotherapeutic strategies. I will recruit a multi-centre cohort of adults with chronic hepatitis B infection (CHB) in Africa and the UK, to study factors associ… more
Biomedical Vacation Scholarship
Multisensory Convergence and Integration in Thalamic and Cortico-Thalamo-Cortical Circuitry
<p>The thalamus occupies a unique position. All sensory information, but olfaction, travels through the thalamus before reaching its cortical destination. Furthermore, it has been found to be mediating communication between several cortical areas. However, the functional anatomy and role of such cortico-thalamo-cortical circuits are poorly understood in sensory processing. The thalamus has also b… more
Examining the predictive coding framework in somatosensory cortex
<p>The PhD project proposes to test the yet unverified theory of predictive coding in sensory cortex,which posits that sensory cortices do not passively register bottom-up inputs but instead represent thediscrepancy between expected and actual perceptual inputs provided by the environment. This will be examined using multi-unit recordings in the somatosensory cortex of awake head-fixed mice train… more
Public Engagement Provision
Public health organizations such as the NHS, the CDC and the WHO have established public health campaigns aimed at informing the public regarding the dangers of antibiotic resistant bacteria. What is unique about this research program is that we will investigate how antibiotic use alters the genetic composition of bacterial populations within an individual patient, and our results will provide so… more
Provision for Public Engagement.
i. Vision The fact that approximately half the world's population is at risk from malaria makes it a compelling subject for public engagement. Seemingly intractable or resurgent malaria, and escalating drug and insecticide resistance, will ensure that malaria remains central to the concerns of medical scientists, health-workers and policy-makers. Our vision for public/professional engagement embr… more
Public Engagement Provision.
1. How can we improve the development of assisted living technologies (ALTs) by and for people with multi-morbidity and declining health? 2. How can we better promote the customisation and use of such technologies inthe home and the community by individuals, their carers and support services? 3. How can we ensure that ethical and existential concerns (what matters to people?; what are homes for?;… more
The effect of preparatory activity on the processing of behaviourally relevantstimuli.
<table> <tbody> <tr> <td>The mossy fibre synapse projects from granule cells in the dentate gyrus and permits powerful excitatory drive balanced by feedforward and feedback inhibition via interneurons. Granule cells display a diverse portfolio of firing patterns that correspond to particular behavioural states. Since very little is known about the variety of fee… more
Monitoring and controlling ion dynamics in parvalbumin-expressing interneuronsduring epileptiform activity.
<table> <tbody> <tr> <td>The disrupted interplay between excitation and inhibition within neuronal networks has long been implicated in seizure pathophysiology. Pharmacological blockade of synaptic inhibition promotes epileptic activity and when inhibitory restraint upon network activity fails, spatially clustered excitatory pyramidal neurons are recruited to ep… more
Medieval Medicine in Board and Card Games.
<p>In the mid-13th century, a practicing physician in Syria named Ibn Abi Usaybi`ah set himself the task of recording the history of medicine throughout the known world. His book The Best Accounts of the Classes of Physicians covers 1700 years of medical practice, from the mythological beginnings of medicine with Asclepius through Greece, Rome, and India, down to the author's day. Written a… more
Beyond the hospital: strengthening dialogue to improve health outcomes.
This project aims to stimulate dialogue between patients with central nervous system infections (CNSIs), their carers, and researchers, hospital staff and rehabilitation organizations, to strengthen capacity for communication, engagement between researchers and the public, and to identify factors that may improve recovery post-discharge. The project wil be conducted at the Hospital for Tropical D… more