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Vacation Scholarships 2018 - University of Oxford
CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Structural studies of the host-parasite interactions at the heart of malaria pathogenicity
<p>Our proposed activities consist of two major strands.</p> <p> </p> <p>Firstly we wish to take our research on tour, developing a high quality interactive stall which will allow us to present our findings to those who visit science fairs. We have secured a place at the Royal Society Summer Science Exhibition in July 2018, as the first outing for our display and this provides the deadline… more
<p>'Sacred Water' – an engagement project run by artist Lena Bui, was a creative space for researchers at OUCRU-Nepal and people living in the Kathmandu Valley to discuss health with a focus on water. However, the earthquake of 2015 caused many participants to reflect on a wider view of health. Lena became interested in what people turn to for a sense of wellbeing - cultural… more
Vacation Scholarships 2017 - University of Oxford
<p>Vacation Scholarships 2017-University of Oxford</p>
Sun Dial: Night Watch.
In the project 'Sun dial : Night watch', scientist Katharina Wulff and artist Susan Morris will create artwork for display at the John Radcliffe Hospital, Oxford. Our aim is to raise public awareness of so-called 'social jetlag': the rising drift between our innate biological clock and manmade routines that modem society imposes upon us. The effects of electric lighting, of organising ourselves a… more
Student Elective prize for the University of Oxford.
p(L)ace of change
p(L)ace of change (PoC) is a media led investigation into the rapid development occurring in Viet Nam; the impact this change has on health and wellbeing and what communities have to say about it. For this first phase, we will deliver a series of community authored films tied together with professional media, developed in consultation with scientists. The resulting DVD will then be used in facili… more
Biomedical Vacation Scholarship
Development of thalamocortial connections in mouse barrel cortex: Role of subplate neurons.
The overall aim is to understand the development of synaptic interactions in the early thalamus-subplate-layer 4 microcircuit of mouse barrel cortex. Two specific objectives have been identified: 1. To determine the developmental profile of synaptic function at three identified synapses within this microcircuit during early postnatal development, and 2. To test the hypothesis that spike timing-dependent plasticity can explain the developmental changes at these three synapses.
Investigating candidate genes in fear related behaviours.
There are four main aims of this project. First, identify candidate genes that are implicated in fear related phenotypes, using the existing data. Second, confirm the molecular lesions in the cases of CNVs. Third, find or create resources to test the involvement of the genes. Finally, characterize the behavioural phenotypes of the mutant mice that are being investigated.
Investigation of the role ofvaccine induced Th17 and regulatory T cells in protection from tuberculosis disease.
1) To investigate the impact of TB and HIV infection on the establishment of Th1, Th17 and T regulatory T cell responses in humans vaccinated with the virally vectored TB vaccine, MVA85A. 2) To investigate Th17 and regulatory T cell induction in mice vaccinated with BCG and MVA85A and to determine the role of these cells in protection against an M. tuberculosis aerosol challenge. 3) To investigat… more
Identification of the molecular mechanisms of Il-23-driven intestinal inflammation.
Maintenance of the integrity of the gastrointestinal tract requires a delicate balance between proinflammatory T effector cell responses directed at pathogenic organisms and anti-inflammatory T regulatory cell (Treg) responses toward the commensal flora . In individuals suffering from inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, this balanced intestinal im… more
iNKT cells as key mediators of inflammation - Dissecting the role played by iNKT cells in haematopoiesis.
The overall aim of this research programme is to investigate the role played by invariant NKT cells in myelopoiesis; in influencing the differentiation of cells along the myeloid lineage, key players in inflammation. Research will be divided into three complementing programmes: Objective 1: Identification of leukocyte populations which require iNKT cells for differentiation Objective 2: Test the … more
Investigating the function of the non-specific X-linked mental retardation protein IIRAPL.
Non-specific X-linked mental retardation (NS-XLMR) affects approximately 1 in 1 ,000 males and mutations in a series of genes have been associated with this inborn disease. By examining the normal function of these genes and how their mutations result in cognitive impairment, it is hoped that we will develop a general understanding of this condition and thereby identify new avenues for treatment.… more
Receptive field development and plasticity of distinct cell types in the developing visual system.
This project will investigate how different neurons within a neural circuit establish their morphological identity and how they acquire their specific response properties. The research will focus on the retinotectal system of Xenopus Laevis tadpoles. This system represents the Xenopus' primary visual pathway, where axons from the retinal ganglion cells in the eye project to the brain and form syn… more
DNA origami: how do you fold a genome?
<p>Recent advances in DNA sequencing technology mean that it is now possible to identify genetic variants in patients with specific diseases which either cause or alter their risk of developing that disorder. However, linking these variants to the genes they regulate and the symptoms of the condition itself is time-consuming and challenging. The overarching aim of this project is to develop high-… more
Using genetic diversity to map fine-scale epidemiology in malaria
<p>The recent evolution of artemisin-resistant strains of P.falciparum in Southeast Asia have highlighted the need for a deeper understanding of the genetic epidemiology of malaria and for more strategic implementation of malaria control resources. Assessment of the efficacy of these control efforts requires accurate and standardised estimates of epidemological parameters, such as transmission in… more
Statistical models of gene-environment interactions
<p>This PhD focuses on developing statistical methods to discover gene – environment (G-E) interactions. To date there has been some interest in testing for G-E interactions in animal models, but limited success in uncovering examples of G-E interactions in humans. This is in part due to the problem of exposure assessment, or rather, because representative data on the environment of a numbe… more