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Vacation Scholarships 2018 - University of Oxford
CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Structural studies of the host-parasite interactions at the heart of malaria pathogenicity
<p>Our proposed activities consist of two major strands.</p> <p> </p> <p>Firstly we wish to take our research on tour, developing a high quality interactive stall which will allow us to present our findings to those who visit science fairs. We have secured a place at the Royal Society Summer Science Exhibition in July 2018, as the first outing for our display and this provides the deadline… more
<p>'Sacred Water' – an engagement project run by artist Lena Bui, was a creative space for researchers at OUCRU-Nepal and people living in the Kathmandu Valley to discuss health with a focus on water. However, the earthquake of 2015 caused many participants to reflect on a wider view of health. Lena became interested in what people turn to for a sense of wellbeing - cultural… more
Vacation Scholarships 2017 - University of Oxford
<p>Vacation Scholarships 2017-University of Oxford</p>
How does memory inflation occur? Analysis using novel adenovirus constructs
<p>The research is aimed at a basic immunologic question highlighted through murine cytomegalovirus (MCMV) infection, which is how does memory "inflation" occur? In other words, what are the basic molecular and cellular components that are required in order to generate sustained… more
Biomedical Vacation Scholarship
"Bodily functions: the corpus and corpora in ancient literature" to be held in Oxford on 8-9 September 2012
Exosome-based gene therapy for Huntington's disease
1. To investigate the optimal strategies for exosome targeting to the brain in HD 2. To identify the optimal exosome RNAi cargo for suppression of htt expression 3. To evaluate brain-targeted exosomes for their ability to reduce htt expression in vivo and to prevent and/or reverse disease phenotype in a HD disease model.
Immunology, infection and translational medicine - 'Regulation of human and murine neutrophil polarisation through SAA signalling, and the interaction with invariant Natural Killer T cells'
The rational selection and investigation of novel candidate antigens for inclusion in a blood-stage vaccine against Plasmodium falciparum malaria, based on parasitological and immunological considerations.
Immunology, infection and translational medicine - 'Characterisation of the molecular cell biology of interaction of the Leishmania parasite with the host macrophage'
DNA origami: how do you fold a genome?
<p>Recent advances in DNA sequencing technology mean that it is now possible to identify genetic variants in patients with specific diseases which either cause or alter their risk of developing that disorder. However, linking these variants to the genes they regulate and the symptoms of the condition itself is time-consuming and challenging. The overarching aim of this project is to develop high-… more
Using genetic diversity to map fine-scale epidemiology in malaria
<p>The recent evolution of artemisin-resistant strains of P.falciparum in Southeast Asia have highlighted the need for a deeper understanding of the genetic epidemiology of malaria and for more strategic implementation of malaria control resources. Assessment of the efficacy of these control efforts requires accurate and standardised estimates of epidemological parameters, such as transmission in… more
Statistical models of gene-environment interactions
<p>This PhD focuses on developing statistical methods to discover gene – environment (G-E) interactions. To date there has been some interest in testing for G-E interactions in animal models, but limited success in uncovering examples of G-E interactions in humans. This is in part due to the problem of exposure assessment, or rather, because representative data on the environment of a numbe… more