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Vacation Scholarships 2018 - University of Oxford
CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Structural studies of the host-parasite interactions at the heart of malaria pathogenicity
<p>Our proposed activities consist of two major strands.</p> <p> </p> <p>Firstly we wish to take our research on tour, developing a high quality interactive stall which will allow us to present our findings to those who visit science fairs. We have secured a place at the Royal Society Summer Science Exhibition in July 2018, as the first outing for our display and this provides the deadline… more
<p>'Sacred Water' – an engagement project run by artist Lena Bui, was a creative space for researchers at OUCRU-Nepal and people living in the Kathmandu Valley to discuss health with a focus on water. However, the earthquake of 2015 caused many participants to reflect on a wider view of health. Lena became interested in what people turn to for a sense of wellbeing - cultural… more
Vacation Scholarships 2017 - University of Oxford
<p>Vacation Scholarships 2017-University of Oxford</p>
Public Engagement Provision.
Understanding problems in social behaviour after neurological insult is a topic of considerable public interest with potential relevance to a wide range of neurological and neuropsychiatric disorders. I have previously undertaken substantial engagement with the StrokeAssociation, for example in designing information sheets about cognitive problems after stroke, and this has extended to running wo… more
Public Engagement Provision.
1. How can we improve the development of assisted living technologies (ALTs) by and for people with multi-morbidity and declining health? 2. How can we better promote the customisation and use of such technologies inthe home and the community by individuals, their carers and support services? 3. How can we ensure that ethical and existential concerns (what matters to people?; what are homes for?;… more
Biomedical Vacation Scholarship
Beyond the hospital: strengthening dialogue to improve health outcomes.
This project aims to stimulate dialogue between patients with central nervous system infections (CNSIs), their carers, and researchers, hospital staff and rehabilitation organizations, to strengthen capacity for communication, engagement between researchers and the public, and to identify factors that may improve recovery post-discharge. The project wil be conducted at the Hospital for Tropical D… more
Divergent roles of Smad1 and Smad2 in patterning the early mammalian embryo.
<table> <tbody> <tr> <td>The TGF? secreted growth factors bone morphogenetic protein (BMP) and nodal play crucial roles in cell fate specification during vertebrate gastrulation. BMPs, acting via Smad1/5/8 induce 'posterior' or extra-embryonic mesoderm (including the germ cell lineage), whereas nodal signals through Smad2/3 specify the 'anterior' primitive streak and its deriv… more
The relationship between progenitor populations and the organisation of local excitatory synaptic circuits within the mammalian cortex.
<table> <tbody> <tr> <td>A fundamental question in neuroscience is how neurons establish their functional identity and specific synaptic connections with other cells. However, we still know very little about how, or when, the functional identityand connectivity of an individual neuron becomes constrained during its development. Recent technical advances now make… more
DNA origami: how do you fold a genome?
<p>Recent advances in DNA sequencing technology mean that it is now possible to identify genetic variants in patients with specific diseases which either cause or alter their risk of developing that disorder. However, linking these variants to the genes they regulate and the symptoms of the condition itself is time-consuming and challenging. The overarching aim of this project is to develop high-… more
Using genetic diversity to map fine-scale epidemiology in malaria
<p>The recent evolution of artemisin-resistant strains of P.falciparum in Southeast Asia have highlighted the need for a deeper understanding of the genetic epidemiology of malaria and for more strategic implementation of malaria control resources. Assessment of the efficacy of these control efforts requires accurate and standardised estimates of epidemological parameters, such as transmission in… more
Statistical models of gene-environment interactions
<p>This PhD focuses on developing statistical methods to discover gene – environment (G-E) interactions. To date there has been some interest in testing for G-E interactions in animal models, but limited success in uncovering examples of G-E interactions in humans. This is in part due to the problem of exposure assessment, or rather, because representative data on the environment of a numbe… more
Open Research: Thailand Major Overseas Programme 2015 - 2020
<p style="margin-left: 0cm; margin-right: 0cm">This application is led by Phaik Yeong Cheah, the head of Bioethics & Engagement and co-led by Naomi Waithira, the head of Data Management and supported by Nicholas Day, the Director of the Programme. </p> <p style="margin-left: 0cm; margin-right: 0cm">Upon successful completion of the activity, we would have achieved the following:</p> <p… more
Planning meeting for Lancet Commission on Diagnosis
<p>The Lancet Commission on Diagnosis</p> <p>Phase 1 - Planning Meeting</p> <p>Following the publication of The Lancet Series on Pathology in Low and Middle Income countries in March, the Lancet asked me to lead a Lancet Commisison on Diagnosis (Pathology and Laboratory Medicine and Imaging). </p> <p>There will be two phases. The first will be a 1.5 day face-to-face… more
Expanding the Inventory Records and Online Profile of Early Modern Medical Books at the Science Museum
<p>The short-term goal of my six-month project is to create a new inventory of the Science Museum’s 158 pre-1800 medical books which would contain more up-to-date, detailed information about the contents, physical format and publication circumstances of the predominantly Latin and English codices. I also intend to explore and document links between the books and the museum’s large col… more