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Search results (Displaying 83 grants)

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Earliest award date
29 Feb 2016
Latest award date
15 Nov 2018
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Amount: £11,000
CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Amount: £21,120
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Amount: £22,186
Structural studies of the host-parasite interactions at the heart of malaria pathogenicity
<p>Our proposed activities consist of two major strands.</p> <p>&nbsp;</p> <p>Firstly we wish to take our research on tour, developing a high quality interactive stall which will allow us to present our findings to those who visit science fairs. We have secured a place at the Royal Society Summer Science Exhibition in July 2018, as the first outing for our display and this provides the deadline… more
Amount: £49,000
Discretionary Award
<p>'Sacred Water' &ndash; an engagement project run by artist Lena Bui, was a creative space for researchers at OUCRU-Nepal and people living in the Kathmandu Valley to discuss health with a focus on water.&nbsp; However, the earthquake of 2015 caused many participants to reflect&nbsp;on a wider view of health. Lena became interested in what people turn to for a sense of wellbeing&nbsp;- cultural… more
Amount: £40,000
Vacation Scholarships 2017 - University of Oxford
<p>Vacation Scholarships 2017-University of Oxford</p>
Amount: £15,500
Defining host and viral factors that are associated with hepatitis B virus control and clearance in Caucasian and African adults.
HBV accounts for a significant global burden of liver disease. This project is founded on the urgent need to characterise T cell responses in order to enhance our understanding of differential outcomes of infection, and underpin future immunotherapeutic strategies. I will recruit a multi-centre cohort of adults with chronic hepatitis B infection (CHB) in Africa and the UK, to study factors associ… more
Amount: £11,450
Multisensory Convergence and Integration in Thalamic and Cortico-Thalamo-Cortical Circuitry
<p>The thalamus occupies a unique position. All sensory information, but olfaction, travels through the thalamus before reaching its cortical destination. Furthermore, it has been found to be mediating communication between several cortical areas. However, the functional anatomy and role of such cortico-thalamo-cortical circuits are poorly understood in sensory processing. The thalamus has also b… more
Amount: £41,872
Examining the predictive coding framework in somatosensory cortex
<p>The PhD project proposes to test the yet unverified theory of predictive coding in sensory cortex,which posits that sensory cortices do not passively register bottom-up inputs but instead represent thediscrepancy between expected and actual perceptual inputs provided by the environment. This will be examined using multi-unit recordings in the somatosensory cortex of awake head-fixed mice train… more
Amount: £22,823
DNA origami: how do you fold a genome?
<p>Recent advances in DNA sequencing technology mean that it is now possible to identify genetic variants in patients with specific diseases which either cause or alter their risk of developing that disorder. However, linking these variants to the genes they regulate and the symptoms of the condition itself is time-consuming and challenging. The overarching aim of this project is to develop high-… more
Amount: £35,850
Human Genetics and Disease Biology: Core Renewal for the Wellcome Trust Centre for Human Genetics
<p>Human genetics provides a unique and powerful tool for understanding normal biology, disease pathophysiology, and infectious mechanisms.&nbsp; The &ldquo;genetic revolution&rdquo; of the last decade has witnessed an explosion in knowledge of associated variants for individual traits.&nbsp; Looking forward, large population resources will facilitate a new paradigm, going from variants (individu… more
Amount: £15,178,415
Wellcome Centre for Integrative Neuroimaging
<p>Understanding how interactions between neurons generate human behaviour, why individual brains vary from one another, or whether a patient is likely to develop a particular disease,&nbsp;requires explanations that span vast differences in scale. Yet such explanations are essential if insights from neuroscience are to make a meaningful impact on human health. Precise mechanisms discovered in an… more
Amount: £11,463,085
Using genetic diversity to map fine-scale epidemiology in malaria
<p>The recent evolution of artemisin-resistant strains of P.falciparum in Southeast Asia have highlighted the need for a deeper understanding of the genetic epidemiology of malaria and for more strategic implementation of malaria control resources. Assessment of the efficacy of these control efforts requires accurate and standardised estimates of epidemological parameters, such as transmission in… more
Amount: £0
Statistical models of gene-environment interactions
<p>This PhD focuses on developing statistical methods to discover gene &ndash; environment (G-E) interactions. To date there has been some interest in testing for G-E interactions in animal models, but limited success in uncovering examples of G-E interactions in humans. This is in part due to the problem of exposure assessment, or rather, because representative data on the environment of a numbe… more
Amount: £0
Franz Kafka's A Hunger Artist: Exploring Anorexia Nervosa on Film
<p>Created through interdisciplinary and artistic collaborations,<em> Franz Kafka&rsquo;s A Hunger Artist</em>, an adaptation of Kafka&rsquo;s classic short story, will, in dynamic interplay, depict aspects of anorexic psychology and by contrast, invite vivid experiences of healthy embodiment.&nbsp; It will explore two opposing ways of looking:&nbsp; a voyeuristic gaze that objectifies and specta… more
Amount: £39,976
Workshop: Human evolution in structured populations
<p>Understanding the origins and early demographic history of our species has wide ranging implications for the medical, social and biological sciences. Until recently, consensus for a single East African centre of endemism for Homo sapiens was widespread. However, archaeological, fossil and genetic data increasingly suggest that the emergence of our species occurred within a set of subdivided po… more
Amount: £5,000
Open Research: Thailand Major Overseas Programme 2015 - 2020
<p style="margin-left: 0cm; margin-right: 0cm">This application is led by Phaik Yeong Cheah, the head of Bioethics &amp; Engagement and co-led by Naomi Waithira, the head of Data Management and supported by Nicholas Day, the Director of the Programme.&nbsp;</p> <p style="margin-left: 0cm; margin-right: 0cm">Upon successful completion of the activity, we would have achieved the following:</p> <p… more
Amount: £49,257
Planning meeting for Lancet Commission on Diagnosis
<p>The Lancet Commission on Diagnosis</p> <p>Phase 1 - Planning Meeting</p> <p>Following the publication of The&nbsp;Lancet Series on Pathology in Low and Middle Income &nbsp;countries in March, the Lancet asked me&nbsp;to lead a Lancet Commisison on Diagnosis (Pathology and Laboratory Medicine and Imaging). &nbsp;</p> <p>There will be two phases. &nbsp;The first will be a 1.5 day face-to-face… more
Amount: £8,000
Expanding the Inventory Records and Online Profile of Early Modern Medical Books at the Science Museum
<p>The short-term goal of my six-month project is to create a new inventory of the Science Museum&rsquo;s 158 pre-1800 medical books which would contain more up-to-date, detailed information about the contents, physical format and publication circumstances of the predominantly Latin and English codices. I also intend to explore and document links between the books and the museum&rsquo;s large col… more
Amount: £13,005