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Search results (Displaying 46 grants)

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Earliest award date
31 Jan 2017
Latest award date
17 Nov 2017
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CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Amount: £21,120
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Amount: £22,186
Discretionary Award
<p>'Sacred Water' &ndash; an engagement project run by artist Lena Bui, was a creative space for researchers at OUCRU-Nepal and people living in the Kathmandu Valley to discuss health with a focus on water.&nbsp; However, the earthquake of 2015 caused many participants to reflect&nbsp;on a wider view of health. Lena became interested in what people turn to for a sense of wellbeing&nbsp;- cultural… more
Amount: £40,000
Vacation Scholarships 2017 - University of Oxford
<p>Vacation Scholarships 2017-University of Oxford</p>
Amount: £15,500
DNA origami: how do you fold a genome?
<p>Recent advances in DNA sequencing technology mean that it is now possible to identify genetic variants in patients with specific diseases which either cause or alter their risk of developing that disorder. However, linking these variants to the genes they regulate and the symptoms of the condition itself is time-consuming and challenging. The overarching aim of this project is to develop high-… more
Amount: £35,850
Using genetic diversity to map fine-scale epidemiology in malaria
<p>The recent evolution of artemisin-resistant strains of P.falciparum in Southeast Asia have highlighted the need for a deeper understanding of the genetic epidemiology of malaria and for more strategic implementation of malaria control resources. Assessment of the efficacy of these control efforts requires accurate and standardised estimates of epidemological parameters, such as transmission in… more
Amount: £0
Statistical models of gene-environment interactions
<p>This PhD focuses on developing statistical methods to discover gene &ndash; environment (G-E) interactions. To date there has been some interest in testing for G-E interactions in animal models, but limited success in uncovering examples of G-E interactions in humans. This is in part due to the problem of exposure assessment, or rather, because representative data on the environment of a numbe… more
Amount: £0
Dengue Controlled Human Infection Model - Development Grant
<p>Following a positive response to the&nbsp;preliminary submission for grant funding&nbsp;to&nbsp;establish a Dengue Controlled Human Infection Model (Dengue-CHIM )&nbsp;in Ho Chi Minh City, Vietnam, I am submitting this request&nbsp;for a small grant&nbsp;to assist in refining and&nbsp;developing the main proposal prior to&nbsp;final&nbsp;submission in March 2018.</p> <p>&nbsp;</p> <p>During … more
Amount: £23,690
Facing ethics: Identifying ethical issues in computational phenotyping research
<p>Computational phenotyping research uses big data methods to refine the diagnosis of rare genetic diseases. Photographs (and other biomedical data) of people with genetic syndromes are used to train machine-learning algorithms to identify the phenotypic features associated with different disorders. The data are obtained from consortia of clinicians and researchers involved in rare disease resea… more
Amount: £27,408
Improving health outcomes for looked after children and young people
<p>Previous research suggests that looked after children are less likely to be treated in the way that the statutory guidance on promoting the health and well-being of looked after children recommends, and that they receive worse healthcare in comparison to their non-looked after peers. They also have worse experiences of the health service, and due to complex and time consuming policies and proc… more
Amount: £8,010
Exploiting whole genome tagging of trypanosomes to identify new ciliopathy candidate genes in humans
<p>Ciliopathies are a range of human genetic diseases in which the normal functions of cilia/flagella are disrupted or prevented entirely. Ranging from mild to embryonically lethal, these diseases are often difficult to investigate as many do not appear to have clear links with particular genes or molecular mechanisms. This project aims to identify potential ciliopathy protein candidates and thei… more
Amount: £0
Mechanical testing of tendons and ligaments
<p>The mechanism for collagenous connective&nbsp;tissue damage is&nbsp;little understood. The micromechanics of collagenous tissues is&nbsp;important&nbsp;to understand as it may&nbsp;contribute&nbsp;to injury prevention and be useful in designing treatments for pre existing tissue damage. Bontempi et al in 2009&nbsp;theorised a relationship between the the probability density function of the str… more
Amount: £0
Evidence for a pathogenic link between lung inflammation and autoimmune arthritis
<p>Our overall objective is to experimentally identify the early immunological events which trigger a spontaneous breach of tolerance in genetically susceptible mice, and, which can be linked to the development of arthritis. We will analyse the immunological reactivity of the lungs of susceptible mice to environmental stresses such as microbes. Our purpose is to identify early biomarkers of autoi… more
Amount: £0
Myeloid effector cells in inflammation
<p>Dysregulation of inflammation underlies a range of chronic inflammatory disease. By increasing our understanding of inflammatory mechanisms we may be able to identify specific therapeutic targets to treat disease. &nbsp;Using a murine model of acute, resolving inflammation, with zymosan as stimulus, we create a physiological inflammatory system where we can observe the spatiotemporal relations… more
Amount: £0
How do CHRND mutations disrupt AChR cluster formation?
<p>The project aims to utilise mutations identified in congenital myasthenic syndromes to study the interactions of the muscle acetylcholine receptor (AChR) and its anchoring protein, Rapsyn.Widely quoted publications suggest that Rapsyn interacts with the M3-M4 intracellular loop of the AChR alpha, beta and epsilon subunits, however we have identified several kinships in which mutations in the M… more
Amount: £0
Design and development of a breathing powered prosthetic prototype
<p>The input required to control a prosthetic device greatly defines the subsequent precision that can be achieved. Robust mechanisms that are low-cost often use musculoskeletal motion for control. However, this often limits the level of control and applicability issues can arise when the system that is augmented also generates the power and drives the control. A device that is powered and contro… more
Amount: £0
Assessing the effect of the Xrn1 exoribonuclease on global and specific rates of protein synthesis
<p>Gene expression is a complex process requiring the coordination of transcription, transcript turnover, translation and proteostasis. When coordinated, these processes can be adapted to allow cells to respond to changes in growth rate and during differentiation. How these processes are coordinated remains a long-standing question. The exoribonuclease Xrn1 is proposed to coordinate transcription… more
Amount: £0
Investigating the role of cyclin-dependent kinases in the regulation of DNA repair by non-homologous end-joining
<p>DNA double-strand breaks (DSBs) are highly toxic lesions that can drive genome instability and cancer. In human cells, most DSBs are repaired by the non-homologous end joining (NHEJ) pathway, except when they occur during DNA replication or mitosis when NHEJ is toxic and can generate chromosomal translocations. NHEJ must therefore be tightly regulated to maintain genome stability. However, lit… more
Amount: £0
Epidemiology and health burdens of antimicrobial resistant bacterial infection in Southeast Asia and impact of antibiotic use on patient survival
<p>Epidemiology of drug-resistant infection (DRI) and impact of antibiotic use on patient mortality remain largely unknown in Southeast Asia. Correction factors are crucial to estimate the total deaths attributable to DRI when only mortality of patients with bacteraemia&nbsp;is known. The correction factors are available for developed country and not for developing country. I aim to establish cor… more
Amount: £18,800
Stochastic variation and regulation of bacterial DNA repair and mutagenesis
<p>Studying the molecular mechanisms of mutagenesis is crucial to understanding genome evolution and the emergence of drug resistance in pathogens. It is known that cellular stress responses increase mutation rates after DNA damage and antimicrobial treatment. Recent evidence suggests that stochastic effects play key roles in these responses, causing cell-to-cell variation in mutation rates and d… more
Amount: £25,000