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Search results (Displaying 35 grants)

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Earliest award date
17 Oct 2005
Latest award date
07 Dec 2017
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Implementation of ISARICC's 2018-2022 Strategic Plan
<p>Bridging funds for transition to ISARICC's 2018-2022 Strategic Plan</p>
Amount: £144,634
Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Amount: £98,762
The impact of vaccine platform on the cellular drivers of humoral immunity
<p>The focus of this Fellowship proposal is on how vaccine platform affects the cellular drivers of humoral immunity, specifically memory B cells (mBCs) and T follicular helper (Tfh) cells. I will compare the leading <em>Plasmodium falciparum</em> blood-stage malaria candidate &ndash; RH5 &ndash; in two vaccine platforms: heterologous viral vectors (chimp adenovirus 63 prime, Modified Vaccinia An… more
Amount: £250,000
The Ethics of Genome Editing in Livestock
<p>Genome editing in livestock (GEL) could potentially be used to mitigate urgent global problems of infectious disease, antimicrobial resistance, global warming, and animal suffering while also increasing agricultural productivity. Despite its imminence and potentially transformative potential, there has been minimal ethical debate about GEL. This project will provide the first in-depth philosop… more
Amount: £227,968
The role of diurnal intracellular chloride changes in cortical network activity and plasticity.
<p>Cyclical changes between sleeping and waking states are a fundamental feature of mammalian physiology. During these different states, our brains exhibit distinct patterns of network activity and different capacities to learn. An understanding of the cellular mechanisms that underlie these processes is important to fully appreciate how daily changes in brain function contribute in health and di… more
Amount: £250,000
A realist review of community engagement with health research
<p>The project will conduct a comprehensive review of community engagement using a realist review approach appropriate for tackling the conceptual complexity and practical diversity of the field. A review team with worldleading expertise in the theory and practice of CE will be supported by an advisory panel of internationally renowned realist review scholars. The review will begin with engagemen… more
Amount: £260,250
Overcoming contraceptive discontinuation by overcoming side-effects: paving the way for personalized contraception in Ethiopia
<p>In the developing world, millions of women discontinue hormonal contraception due to the experience of debilitating physiological side-effects (e.g. excessive and irregular bleeding), yet the causes of these adverse effects is not known. This project will be the first to test the hypothesis that side-effects are caused by unnecessarily high dosage of exogenous hormones in hormonal contraceptiv… more
Amount: £97,126
Exploring mechanisms of enhancer action in erythropoiesis
<p>DNA sequences called enhancers control gene expression in time and space by activating genes during key cell-fate decisions. The specific combinations of genes activated by enhancers contribute to cellular behaviour, genetic predisposition to disease and phenotypic variation between species. My aim is to understand precisely <em>how</em> enhancers activate genes during differentiation.</p> <p… more
Amount: £250,000
Closing the loop on neuronal oscillations: Motor networks take centre stage
<p>The idea that brief periods of coherence or phase-locking in rhythmic activity mechanistically facilitate&nbsp;communication across distributed cortical networks is hotly debated. It is thought to underlie processes like attention and working memory yet much of the evidence remains correlative. I propose to design and utilise a digital circuit to optogenetically entrain or damp rhythmic activi… more
Amount: £250,000
Neural mechanisms supporting environment evaluation in humans and their breakdown in clinical disorders
<p>My goal in this proposal is to understand the neurocognitive mechanisms by which individuals evaluate their environment.</p> <p>&nbsp;</p> <p>First, I will use computational modelling to characterise how individuals adjust their estimates of the reward rate in an environment on a trial by trial basis. I will manipulate the reward rate over time and model how individuals respond to these chan… more
Amount: £250,000
Modelling the impact of poor quality antimicrobials on patient outcome and drug resistance – a pilot study to inform policy in the absence of empirical data
<p>Antimicrobial resistance (AMR) is an increasingly serious and pressing global public health problem.</p> <p>Poor antimicrobial quality is increasingly realised as an important rectifiable impediment to global public health. There has been little discussion or evidence as to its comparative importance, in relation to other drivers such as poor prescribing and adherence, for both poor patient ou… more
Amount: £99,994
Enhancing Summative Assessment of Practical Science: A Systemic Approach
What makes plants grow? What are stars made of? Scientists answer such questions by collecting and interpreting data. Sometimes scientists use experiments where they change conditions and study the effects of changes. For instance, in the case of plant growth, the amount of sunlight and water can be manipulated to see if they make any difference. Scientists use different approaches to practical w… more
Amount: £270,773
Spellbound - Magical Thinking Past and Present
The Ashmolean Museum, Oxford, will hold the first ever large-scale exhibition focusing on the history of magical thinking from 6 September 2018 to 6 January 2019. Through the exhibition and public engagement programme, we aim to provoke fresh discussion about aspects of psychology and mental health that are rarely talked about but highly accessible and relevant on a daily basis. It will include… more
Amount: £50,000
Forecasting dengue cases: Vietnam as a case study
<p>Vector-borne infectious diseases continue to be a burden to Vietnam&rsquo;s economy and population health. Understanding the spatiotemporal patterns of the disease transmission is thus vital for planning resources and targeting control measures. In this work, we propose a large-scale study on how different factors interact and contribute to the dynamics of dengue in Vietnam.</p> <p>We will em… more
Amount: £82,952
The evaluation of effective healthcare delivery in China using electronic medical records for 10 years in 0.5M participants in the China Kadoorie Biobank
<p>This&nbsp;DPhil project will&nbsp;assess the social determinants and&nbsp;equality&nbsp;in hospital care delivery and use, in 0.5 million participants who have been followed up for 10 years in the China Kadoorie Biobank. The first&nbsp;goal&nbsp;of this research is&nbsp;to&nbsp;evaluate differences in the annual rates of people hospitalised, the annual rates of hospital admissions per person, … more
Amount: £95,184
Healing Heathen Lands: Protestant Missions and Public Health in British India, 1855-1956
<p>This project will explore the role of Protestant missions in the making of British Indian public health by tracing the interactions between evangelical, colonial and vernacular sources. It will argue that Protestant missionaries in South Asia did not merely play a complementary role to imperial biomedicine. It will examine the ways in which missions&nbsp;contributed towards shaping colonial he… more
Amount: £174,774
Molecular characterisation of antibiotic tolerance in Mycobacterium tuberculosis
Tuberculosis, caused by Mycobacterium tuberculosis still causes 1.8 million deaths per year and takes months to years to treat. Long treatment times are due to subpopulation(s) of bacteria that, although genetically susceptible, are not killed effectively by antibiotics – termed antibiotic tolerance. Understanding mechanisms of antibiotic tolerance is the key to shortening treatment times for t… more
Amount: £236,883
Understanding mechanisms that drive pain perception in early human development
<p>Pain in infancy has negative long-term consequences and its prevention is a clinical priority, but adequate treatment requires mechanistic understanding of the structural and functional development of human nociceptive circuitry. Recent scientific and technological advances provide insights into how noxious information is transmitted to the infant brain, providing a platform to ask how intrins… more
Amount: £60,000
Epidemiology and health burdens of antimicrobial resistant bacterial infection in Southeast Asia and impact of antibiotic use on patient survival
<p>Epidemiology of drug-resistant infection (DRI) and impact of antibiotic use on patient mortality remain largely unknown in Southeast Asia. Correction factors are crucial to estimate the total deaths attributable to DRI when only mortality of patients with bacteraemia&nbsp;is known. The correction factors are available for developed country and not for developing country. I aim to establish cor… more
Amount: £184,563
Mechanisms by which missense variants in myosin and myosin binding protein C alter cellular contractility in genetic cardiomyopathies.
<p><strong>Summary:</strong></p> <p>&nbsp;</p> <p>The cardiac sarcomere is a multi-protein complex essential to cardiac contractile function. Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) are caused by pathogenic variants (PV) in sarcomere protein genes. Variants in genes directly involved in cellular contractility <em>MYH7</em> (&beta;-myosin heavy chain), <em>MYH6</em> (&… more
Amount: £250,000