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- 07 Dec 2017
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Implementation of ISARICC's 2018-2022 Strategic Plan
<p>Bridging funds for transition to ISARICC's 2018-2022 Strategic Plan</p>
Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Ethical Lifespan Enhancement.
Current medical and policy strategies have doubled our lifespans over the past century, with a number of corresponding benefits to individuals and societies. However, the cost of these strategies has been a progressive loss of wellbeing amongst the very old, along with a rapid increase in the distributed burdens of aged care. The first goal of this research is to reframe our existing medical stru… more
An investigation into the neurophysiological biomarkers of Parkinsons disease in closed loop deep brain stimulation.
The aim of this project is investigate whether there exist improved neurophysiological biomarkers of Parkinson s disease (PD) over and above the pathological beta synchrony band already described and to examine whether these enhanced biomarkers can be used to improve treatment with deep brain stimulation (DBS) through their modulation of stimulation in a closed loop setting. Specifically, we will… more
Genetic basis of craniofacial malformations.
1. Prospective ascertainment of patients requiring craniofacial surgery at the four participating centres. We will aim to recruit a minimum of 150 patients (with parents) annually. 2. Identification of new monogenic causes of craniofacial malformation within this cohort using massively parallel sequencing. We will use 16 lanes of Illumina-based sequencing of captured whole exomes in patients or … more
Regulation of growth and TORC1 signalling by the novel evolutionarily conserved amino acid transporter, SLC38A10: a new player in amino acid sensing?.
We will dissect out the functions and mechanism of action of the growth regulatory SLC38A10 transporter in Drosophila, using the combination of genetic and molecular genetic approaches we have developed in our pioneering studies of amino acid sensing by the PATs. We will employ analysis of mutant animals and somatic mutant clones, RNAi and overexpression studies to determine in which tissues SLC3… more
Open Access award.
Generation of an antibody library against transcription factors.
<table> <tbody> <tr> <td>Adapting specific anti-peptide phage combinatorial library technology to a peptide capture phage assay in generating anti-transcription factor antibodies</td> </tr> </tbody> </table>
Comprehensive assessment of the role of methylation in Obesity and Type 2 Diabetes, using a combined genetics and cell biology approach
Structural Studies of the Influenza RNA Polymerase
Structural and Biophysical Characteristics of the interaction of the PfRh proteins with their ligands and inhibitory antibodies:understanding an interactionessential for the invasion of erythrocytes by the malaria parasite.
Specifying the role of Asterless (Asl) in centrosome formation and function through characterization of its dynamic localization at centrosomes
Investigating the role of PCP signalling during Anterior Visceral Endoderm migration in the mouse embryo
Molecular Genetic Analysis of Cell Function and Behaviour in the Drosphila Accessory Gland, a Novel Model for Prostate Biology
Structure and Function of the Reticulon Homology Domain
Investigating the role of G protein signalling in cranial sensory neuroblast differentiation and migration
Infection, Immunology and translational medicine.
Immunology, infection and translational medicine.