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Search results (Displaying 101 grants)

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Earliest award date
17 Jan 2011
Latest award date
07 Dec 2017
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Implementation of ISARICC's 2018-2022 Strategic Plan
<p>Bridging funds for transition to ISARICC's 2018-2022 Strategic Plan</p>
Amount: £144,634
Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Amount: £98,762
A randomised controlled trial to test the effectiveness of a brief intervention for weight management for obese adults in primary care.
<p>Obesity, a major cause of chronic disease, affects 25% of adults. Even a small loss of weight is likely to reduce the risk of chronic diseases occurring, such as diabetes that are the consequence of being overweight. We can use lessons learnt from tobacco control and apply these to obesity. GPs make unsolicited brief interventions frequently on smoking and problem drinking, which are known to … more
Amount: £125,673
FLICC (Front of pack food labelling: Impact on consumer choice)
<p>Since 2006, retailers and manufacturers in the UK have begun using front of pack (FOP) nutrition labelling on foods. Presently, around four fifths of foods in UK supermarkets carry FOP labelling. There have been many studies of consumer understanding of FOP labelling, and of use of FOP labelling in experimental settings. However, little is known about how consumers use FOP labelling in real-li… more
Amount: £109,774
International Severe Acute Respiratory Infection Consortium (ISARIC)
It has become increasingly recognized from a series of recent outbreaks of emerging pathogens of global public health importance that mounting clinical research in response toa rapidly emerging infectious disease is extremely challenging, often delayed and of increasing importance. The Consortium will establish a new paradigm for collaborative clinical research in rapidly emerging public health t… more
Amount: £125,000
Healing the Other: a comparative history of missionary healthcare among an Amazonian people, Suriname-Brazil 1959-1994.
Healing the Other is a comparative study of two missionary primary healthcare systems established among the Trio, a native Amazonian population who live on either side of the border separating Suriname and Brazil. From 1959 until 1994, Franciscan priests and Protestant missionaries were granted exclusive access for the provision of healthcare by the states of Brazil and Suriname respectively. As … more
Amount: £145,894
Influence of host genetics and Mycobacterium tuberculosis strain variation on macrophage function and TB clinical outcome.
The contribution of host genetics and Mtb strain variation to bacterial dissemination in TB are not fully understood. An impairment of macrophage function under the influence of these two factors may help explain the pathogenesis of TB and its different clinical presentations. This project has three key goals. 1) To determine whether host genetic variants of genes related to phagosomal function a… more
Amount: £171,773
Amount: £75,000
Open access award.
Not available
Amount: £250,000
C-Slide - The contributions of Sherrington and Le Gros Clark to our understanding of the brain and nervous system.
Virtual microscopy has great potential for safeguarding and improving access to the historical slides and related documents which underpin modern neuroscience, but which are inaccessible and/or too fragile to use, and in constant danger of being discarded or lost in medical schools and bioscience departments across the UK and internationally. There is considerable research, teaching and general i… more
Amount: £99,858
Infection, Immunology and Translational Medicine-'Towards the development of auniversal influenza vaccine:Investigation of heterosubtypic humoral and cellular immune responses to influenza induced by vaccincation with viral
Seasonal influenza epidemics and pandemics are associated with a non-trivial mortality, morbidity and carry a heavy socioeconomic burden. Vaccination is still the primary strategy for the prevention and control of influenza despite the limitations of currently licensed vaccines and their requirement of periodic reformulation and annual revaccination of at-risk individuals. A first generation T-ce… more
Amount: £156,774
Infection, Immunology and Translational Medicine - 'Control of intestinal immunity by the autophagy protein ATG16L1'
Autophagy is a process of recycling intracellular components in response to starvation or stress. It is also involved in clearance of defective organelles, intracellular pathogens and protein aggregates. Polymorphisms in autophagy genes were recently associated with susceptibility to inflammatory bowel disease (IBD); however the mechanisms responsible for this correlation remain unclear. Clinical… more
Amount: £156,774
Infection, Immunology and Translational Medicine - 'Establishment of a transgenic zebrafish model to study the innate immune response to melanoma'
Although immune mechanisms, such as cytokines produced by immune cells in response to the tumour environment, may provide protection against cancer by elimination of transformed cells, they may also aid tumour development by immunosuppressive mechanisms. Epigenetic mechanisms that alter chromatin landscape, enabling the unwrapping of transcriptional programs play important roles in all cellular p… more
Amount: £156,774
Infection, Immunology and Translational Medicine - 'The role of novel members of the IL-1 family in psoriasis'
The IL-1 family cytokines IL-33 and IL-36s are increased in inflammatory skin disease but little is known about their function. In this project we will perform a systematic analysis of the role of IL- 1 family members in inflammatory skin diseases. We will determine how they influence disease initiation and perpetuation. The study will focus on in vivo as well as in vitro evaluation of IL- 33, IL… more
Amount: £156,774
Infection, Immunology and Translational Medicine - 'Investigating the mechanism of non-catalytic tyrosine phosphorylated receptor triggering'
The central goal of this project is to investigate the mechanism of non-catalytic tyrosine phosphorylated receptor (NTR) triggering. These receptors share a number of features. For example, they contain, or associate with adaptor molecules that contain, tyrosine residues that are phosphorylated by extrinsic kinases, and have comparatively small extracellular domains which bind surface-associated … more
Amount: £156,774
Wellcome Trust Clinical PhD Programme at the University of Oxford: 'Autoimmunity in idiopathic epilepsies and encephalopathies of childhood'.
Immune mechanisms are thought to be involved in the pathological disease process in a significant number of childhood (and adult) epileptic syndromes, and seizure related disorders (i.e. encephalitis). The hypothesis that the body's immune system plays an important role in these disorders is based on the following observations: 1) Occurrence of highly specific autoantibodies to important neuronal… more
Amount: £267,921
Wellcome Trust Clinical PhD Programme at the University of Oxford: 'Approaches to understanding regulatory pathways in atherosclerosis using genome-wide mapping of open chromatin with FAIRE-seq in foam cells.
Approaches to understanding regulatory pathways in atherosclerosis using genome-wide mapping of open chromatin with FAIRE-seq in foam cells. Atherosclerotic vascular disease is the leading cause of morbidity and mortality worldwide. Atherosclerosis is an inflammatory condition and the lesions are packed with immune cells. A key pathogenic role is played by lipid loaded macrophages known as foam c… more
Amount: £226,021
Exploring functional and structural plasticity of visual pathways following hemianopia in stroke.
Primary visual cortex damage causes homonymous hemianopia, a loss of visual function on one side of space, which is extremely debilitating and has no effective treatment. Considerable evidence exists, however, to suggest stimuli within the blind hemifield can undergo processing and influence behaviour in a phenomenon known as 'blindsight'. Here we will investigate unconscious visual processing, w… more
Amount: £223,503