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Search results (Displaying 105 grants)

Total grants
105
Total funders
1
Total recipients
1
Earliest award date
14 Jan 2015
Latest award date
07 Dec 2017
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Implementation of ISARICC's 2018-2022 Strategic Plan
<p>Bridging funds for transition to ISARICC's 2018-2022 Strategic Plan</p>
Amount: £144,634
Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Amount: £98,762
Determining how distinct vertebrate promoter classes coordinate cis-regulatory input.
Highly coordinated gene regulation is essential for multicellular development and when perturbed can lead to disease. Normal transcriptional regulation relies on communication between gene promoters and distal regulatory elements (DREs)[9,10], a process that appears to involve extensive interactions between these sites[11-13]. However, the mechanisms driving these interactions remain poorly under… more
Amount: £250,000
Uncovering the Mode of Action of Lipid II Flippase: A New Antibiotic Target.
Understanding the cellular process by which lipid-anchored molecules reverse their polarity to traverse the cell membrane is a fundamental mechanistic question that remains unsolved. I propose to study the lipid II flippase in E. coli, which transports lipid II across the inner-membrane and into the periplasm where peptidoglycan biosynthesis occurs. There has been controversy surrounding the true… more
Amount: £250,000
Role of complex synaptic dynamics for learning and memory.
How can real brains learn to perform diverse tasks so much better than supercomputers? One of the reasons is that synapses, the brain's storage medium for experience and memories, are too simplistic in our models. Commonly described only by single numbers denoting their strength, we have ignored the rich internal dynamics of real synapses. By harnessing this complexity, biological systems outperf… more
Amount: £250,000
Amount: £100,000
Spatio-temporally multiplexed 2-photon imaging determining neural coding principles of sensory perception.
How does the brain encode the contents of sensory perception and translate them into meaningful neuronal representations of our environment? Although we know approximately how sensory input is routed through different brain areas, each extracting distinct aspects of the percept, the neuronal language used to represent sensory experiences remains elusive. Our work aims is to unravel the coding str… more
Amount: £94,898
Amount: £161,673
Amount: £161,673
Amount: £161,673
Amount: £161,673
Amount: £250,316
Amount: £161,673
Amount: £161,673
Amount: £161,673
Amount: £161,673
Amount: £161,673
How do cohesin gene mutations contribute to myeloid leukaemogenesis?
<p>All germ and somatic cells require the cohesin complex for appropriate chromosomal segregation. Cohesin also plays poorly characterised roles in transcriptional regulation. Recurrect aquired mutations in cohesin complex occurs in ~10% of adult Acute Myeliod Leukemia (AML) and ~70% of children with Myeliod Leukemia of Down Syndrome (ML-DS).The mechanisms by which cohesin peturb normal haemopoie… more
Amount: £300,795