Our guide to targeting your search
Your search ‘’ returned 56 results in ‘All grant fields’

Search results (Displaying 56 grants)

Total grants
Total funders
Total recipients
Earliest award date
31 Jan 2017
Latest award date
27 Nov 2018
Export search data:
In Their Own Voices: Vulnerabilities & Abilities of Women, Children, & Families in Health Research
<p>As REACH enters its second year, we have an exciting opportunity to use our early findings and to expand our use of visual methods to spark wider community and public debate about the ethical issues arising in research with women, children&nbsp;and their families in contexts of poverty and gender inequality. This proposal complements existing Africa and Asia Programme provisions for public eng… more
Amount: £140,079
Amount: £150,000
An Extended Pilot for the Human Cell Atlas: Adult tissues, human development and inflammation-mediated pathologies
<p>The Human Cell Atlas (HCA) is an international, collaborative effort that &ldquo;&hellip;aims to define all human cell types in terms of their distinctive patterns of gene expression, physiological states, developmental trajectories, and location&rdquo;.</p> <p>&nbsp;</p> <p>Here, we will contribute directly to the first phase of the HCA by forming an &lsquo;extended pilot&rsquo; to implemen… more
Amount: £389,335
Flexible task representations for intelligent behavior
<p>A long research tradition in cognitive neuroscience has investigated the role of the prefrontal cortex (PFC) in flexible goal-directed behaviour. This work has yielded important insights, e.g., that the PFC&rsquo;s coding properties flexibly adapt when task demands change&nbsp;to prioritise goal-relevant information. However,&nbsp;it relies primarily upon the use&nbsp;of familiar and explicitl… more
Amount: £250,000
Metabolic Characterization of Natural Killer T Cell responses to sterile, hypoxic injury
<p>It has been described that&nbsp;ischemia-reperfusion injury (IRI), such as during&nbsp;organ transplantation,&nbsp;evokes damaging sterile inflammation and secondary tissue injury that is&nbsp;dependent on iNKT cell activation, but the underlying mechanisms remain elusive.&nbsp;Similarly, in sickle cell disease (SCD)&nbsp;mice,&nbsp;RBC sickling and widely disseminated microvascular ischemia&n… more
Amount: £250,000
Amount: £100,000
Amount: £85,000
Implementation of ISARICC's 2018-2022 Strategic Plan
<p>Bridging funds for transition to ISARICC's 2018-2022 Strategic Plan</p>
Amount: £144,634
Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Amount: £98,762
Molecular basis of lipid traffic at interorganelle contact sites
<p>One unsolved mystery of cell biology is how lipids, made in the endoplasmic reticulum, travel to other cellular membranes. This question, originally deemed solved by the discovery of vesicular traffic, was recently spotlighted by the discovery of membrane contact sites (MCS), at which lipid transport proteins (LTP) accumulate. LTPs solubilize and transport lipids between two membranes in vitro… more
Amount: £120,000
Identifying suppressor mutations of ATR-X and ADNP syndromes using a novel CRISPR-based screening method in mice
<p>The recent Deciphering Developmental Disorders Study found that mutations in genes encoding epigenetics proteins are a primary cause of intellectual disability. These disorders are incurable and their underlying mechanisms remain elusive. Intriguingly, varying symptom severity has been described in patients with the same causative mutations for a number of these disorders and phenotypes displa… more
Amount: £250,000
Constructing the 'Gifted Child': Psychology, Family, and Identity in Britain since 1945
<p>This project examines how, when, and why children have been identified as intellectually 'gifted' in Britain since 1945, and how this label has changed children's experiences, family relationships, and life-course.&nbsp; It provides a lens to explore conflicts and collaborations between psychology, neurology, genetics, neuroscience, and education, and analyses how parents and children themselv… more
Amount: £168,359
Mechanobiological control of immune cell activation
<p>Biomedical sciences increasingly recognise the importance of mechanobiology in health and disease. While most mechanisms of the immune response are adequately explained by cell-biology, biochemistry, and genetics, many of its features profoundly depend on biomechanical aspects. <strong>One such scenario involves the ability of immune cells to differently respond to antigens with similar bindin… more
Amount: £98,263
Plasmodium vivax Volunteer Infection Studies in Thailand
<p>Vivax malaria remains a major global health problem. Because of the existence of a hypnozoite stage and the clinical relapses this causes, elimination strategies are more difficult to design and implement successfully than for falciparum malaria. Vaccines and new well-tolerated&nbsp;anti-relapse drugs are badly needed. To accelerate vaccine&nbsp;development, we will develop and assess the feas… more
Amount: £432,298
<p>On January 1, 2018, California enacted Senate Bill 27 (SB27), first-of-its-kind and potentially precedent-setting legislation, which will require a veterinarian&rsquo;s prescription for use of antimicrobial drugs and ban non-therapeutic antimicrobial uses for routine disease prevention and growth promotion in livestock. To assess the effectiveness of this important legislation at reducing anti… more
Amount: £254,330
Investigation of hypoxia-sensing mechanisms in immune regulation
<p>CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells (Tregs) are central to immune regulation and are a promising therapy for the treatment of autoimmunity and transplant rejection, where I am currently leading a clinical trial. Adaptive immune responses are regulated by environmental factors including hypoxia which reduces the activity of prolyl hydroxylase domain (PHD) enzymes… more
Amount: £363,740
The impact of vaccine platform on the cellular drivers of humoral immunity
<p>The focus of this Fellowship proposal is on how vaccine platform affects the cellular drivers of humoral immunity, specifically memory B cells (mBCs) and T follicular helper (Tfh) cells. I will compare the leading <em>Plasmodium falciparum</em> blood-stage malaria candidate &ndash; RH5 &ndash; in two vaccine platforms: heterologous viral vectors (chimp adenovirus 63 prime, Modified Vaccinia An… more
Amount: £250,000
The Ethics of Genome Editing in Livestock
<p>Genome editing in livestock (GEL) could potentially be used to mitigate urgent global problems of infectious disease, antimicrobial resistance, global warming, and animal suffering while also increasing agricultural productivity. Despite its imminence and potentially transformative potential, there has been minimal ethical debate about GEL. This project will provide the first in-depth philosop… more
Amount: £227,968
The role of diurnal intracellular chloride changes in cortical network activity and plasticity.
<p>Cyclical changes between sleeping and waking states are a fundamental feature of mammalian physiology. During these different states, our brains exhibit distinct patterns of network activity and different capacities to learn. An understanding of the cellular mechanisms that underlie these processes is important to fully appreciate how daily changes in brain function contribute in health and di… more
Amount: £250,000
Impact of malaria elimination on immunity and risk of malaria rebound in Myanmar
<p>The emergence and spread of ACT resistant&nbsp;falciparum malaria ,and the discovery that there were substantial reservoirs of subpatent parasites in populations residing at low transmission area has led to calls for radical interventions to eliminate the disease from the Greater Mekong SubRegion. Several pilot studies of mass drug administration (MDA) have now taken place, including two in My… more
Amount: £256,067