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Search results (Displaying 11 grants)

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Earliest award date
31 Jan 2017
Latest award date
04 Dec 2017
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Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Amount: £98,762
Overcoming contraceptive discontinuation by overcoming side-effects: paving the way for personalized contraception in Ethiopia
<p>In the developing world, millions of women discontinue hormonal contraception due to the experience of debilitating physiological side-effects (e.g. excessive and irregular bleeding), yet the causes of these adverse effects is not known. This project will be the first to test the hypothesis that side-effects are caused by unnecessarily high dosage of exogenous hormones in hormonal contraceptiv… more
Amount: £97,126
Modelling the impact of poor quality antimicrobials on patient outcome and drug resistance – a pilot study to inform policy in the absence of empirical data
<p>Antimicrobial resistance (AMR) is an increasingly serious and pressing global public health problem.</p> <p>Poor antimicrobial quality is increasingly realised as an important rectifiable impediment to global public health. There has been little discussion or evidence as to its comparative importance, in relation to other drivers such as poor prescribing and adherence, for both poor patient ou… more
Amount: £99,994
Spellbound - Magical Thinking Past and Present
The Ashmolean Museum, Oxford, will hold the first ever large-scale exhibition focusing on the history of magical thinking from 6 September 2018 to 6 January 2019. Through the exhibition and public engagement programme, we aim to provoke fresh discussion about aspects of psychology and mental health that are rarely talked about but highly accessible and relevant on a daily basis. It will include… more
Amount: £50,000
Forecasting dengue cases: Vietnam as a case study
<p>Vector-borne infectious diseases continue to be a burden to Vietnam&rsquo;s economy and population health. Understanding the spatiotemporal patterns of the disease transmission is thus vital for planning resources and targeting control measures. In this work, we propose a large-scale study on how different factors interact and contribute to the dynamics of dengue in Vietnam.</p> <p>We will em… more
Amount: £82,952
The evaluation of effective healthcare delivery in China using electronic medical records for 10 years in 0.5M participants in the China Kadoorie Biobank
<p>This&nbsp;DPhil project will&nbsp;assess the social determinants and&nbsp;equality&nbsp;in hospital care delivery and use, in 0.5 million participants who have been followed up for 10 years in the China Kadoorie Biobank. The first&nbsp;goal&nbsp;of this research is&nbsp;to&nbsp;evaluate differences in the annual rates of people hospitalised, the annual rates of hospital admissions per person, … more
Amount: £95,184
Understanding mechanisms that drive pain perception in early human development
<p>Pain in infancy has negative long-term consequences and its prevention is a clinical priority, but adequate treatment requires mechanistic understanding of the structural and functional development of human nociceptive circuitry. Recent scientific and technological advances provide insights into how noxious information is transmitted to the infant brain, providing a platform to ask how intrins… more
Amount: £60,000
Analysis of neurodegenerative diseases progression, at a single cell level, with Deep Neural Networks
<p>The aim of the project is to investigate neurodegenerative diseases, by determining novel neuronal cell phenotypes, classify them and to develop a step wise neurodegenerative disease<br>progression map. Stem cells differentiation technology allows scientists to access neurons involved in pathology of various neurodegenerative disease, however, there is big gap in good methods to investigate di… more
Amount: £80,000
Optogenetic analysis of the neural function of 5-HT-glutamate co-transmission
<p>This research investigates the relationship between 5-HT neurons and two key brain functions: sleep-wake changes and fear learning. Of particular interest is the role in these processes of glutamate co-released from 5-HT neurons. Two approaches will be used. One approach is based on recent evidence that glutamate is preferentially released from 5-HT neurons firing at low frequencies, whereas 5… more
Amount: £80,000
Inducing and disrupting white matter plasticity
<p>Recent evidence has shown that dynamical changes in white matter underlie the learning of motor skills. This has been observed both in humans with Diffusion Tensor Imaging (DTI, Schulz et al., 2009) and in rodents with histology (Sampaio-Baptista et al., 2013). These findings raise questions on which conditions are necessary for WM plasticity induction and how the plasticity they induce is mod… more
Amount: £83,102
The role of motor learning and sleep in the modulation of structural and functional long-range connectivity in the rodent brain
<p>Learning new motor skills can trigger new myelin synthesis and induce changes in long-range structural and functional connections in the adult brain. Understanding the biological basis of neuroplasticity is critical for developing interventions for brain injury. It is still not clear, however, whether these structural and functional changes are related. It is also critical to find strategies t… more
Amount: £65,753