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Search results (Displaying 35 grants)

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Earliest award date
31 Jan 2017
Latest award date
04 Dec 2017
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Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Amount: £98,762
Using genetic diversity to map fine-scale epidemiology in malaria
<p>The recent evolution of artemisin-resistant strains of P.falciparum in Southeast Asia have highlighted the need for a deeper understanding of the genetic epidemiology of malaria and for more strategic implementation of malaria control resources. Assessment of the efficacy of these control efforts requires accurate and standardised estimates of epidemological parameters, such as transmission in… more
Amount: £0
Statistical models of gene-environment interactions
<p>This PhD focuses on developing statistical methods to discover gene &ndash; environment (G-E) interactions. To date there has been some interest in testing for G-E interactions in animal models, but limited success in uncovering examples of G-E interactions in humans. This is in part due to the problem of exposure assessment, or rather, because representative data on the environment of a numbe… more
Amount: £0
Overcoming contraceptive discontinuation by overcoming side-effects: paving the way for personalized contraception in Ethiopia
<p>In the developing world, millions of women discontinue hormonal contraception due to the experience of debilitating physiological side-effects (e.g. excessive and irregular bleeding), yet the causes of these adverse effects is not known. This project will be the first to test the hypothesis that side-effects are caused by unnecessarily high dosage of exogenous hormones in hormonal contraceptiv… more
Amount: £97,126
Modelling the impact of poor quality antimicrobials on patient outcome and drug resistance – a pilot study to inform policy in the absence of empirical data
<p>Antimicrobial resistance (AMR) is an increasingly serious and pressing global public health problem.</p> <p>Poor antimicrobial quality is increasingly realised as an important rectifiable impediment to global public health. There has been little discussion or evidence as to its comparative importance, in relation to other drivers such as poor prescribing and adherence, for both poor patient ou… more
Amount: £99,994
Spellbound - Magical Thinking Past and Present
The Ashmolean Museum, Oxford, will hold the first ever large-scale exhibition focusing on the history of magical thinking from 6 September 2018 to 6 January 2019. Through the exhibition and public engagement programme, we aim to provoke fresh discussion about aspects of psychology and mental health that are rarely talked about but highly accessible and relevant on a daily basis. It will include… more
Amount: £50,000
Forecasting dengue cases: Vietnam as a case study
<p>Vector-borne infectious diseases continue to be a burden to Vietnam&rsquo;s economy and population health. Understanding the spatiotemporal patterns of the disease transmission is thus vital for planning resources and targeting control measures. In this work, we propose a large-scale study on how different factors interact and contribute to the dynamics of dengue in Vietnam.</p> <p>We will em… more
Amount: £82,952
The evaluation of effective healthcare delivery in China using electronic medical records for 10 years in 0.5M participants in the China Kadoorie Biobank
<p>This&nbsp;DPhil project will&nbsp;assess the social determinants and&nbsp;equality&nbsp;in hospital care delivery and use, in 0.5 million participants who have been followed up for 10 years in the China Kadoorie Biobank. The first&nbsp;goal&nbsp;of this research is&nbsp;to&nbsp;evaluate differences in the annual rates of people hospitalised, the annual rates of hospital admissions per person, … more
Amount: £95,184
Understanding mechanisms that drive pain perception in early human development
<p>Pain in infancy has negative long-term consequences and its prevention is a clinical priority, but adequate treatment requires mechanistic understanding of the structural and functional development of human nociceptive circuitry. Recent scientific and technological advances provide insights into how noxious information is transmitted to the infant brain, providing a platform to ask how intrins… more
Amount: £60,000
Exploiting whole genome tagging of trypanosomes to identify new ciliopathy candidate genes in humans
<p>Ciliopathies are a range of human genetic diseases in which the normal functions of cilia/flagella are disrupted or prevented entirely. Ranging from mild to embryonically lethal, these diseases are often difficult to investigate as many do not appear to have clear links with particular genes or molecular mechanisms. This project aims to identify potential ciliopathy protein candidates and thei… more
Amount: £0
Mechanical testing of tendons and ligaments
<p>The mechanism for collagenous connective&nbsp;tissue damage is&nbsp;little understood. The micromechanics of collagenous tissues is&nbsp;important&nbsp;to understand as it may&nbsp;contribute&nbsp;to injury prevention and be useful in designing treatments for pre existing tissue damage. Bontempi et al in 2009&nbsp;theorised a relationship between the the probability density function of the str… more
Amount: £0
Evidence for a pathogenic link between lung inflammation and autoimmune arthritis
<p>Our overall objective is to experimentally identify the early immunological events which trigger a spontaneous breach of tolerance in genetically susceptible mice, and, which can be linked to the development of arthritis. We will analyse the immunological reactivity of the lungs of susceptible mice to environmental stresses such as microbes. Our purpose is to identify early biomarkers of autoi… more
Amount: £0
Myeloid effector cells in inflammation
<p>Dysregulation of inflammation underlies a range of chronic inflammatory disease. By increasing our understanding of inflammatory mechanisms we may be able to identify specific therapeutic targets to treat disease. &nbsp;Using a murine model of acute, resolving inflammation, with zymosan as stimulus, we create a physiological inflammatory system where we can observe the spatiotemporal relations… more
Amount: £0
How do CHRND mutations disrupt AChR cluster formation?
<p>The project aims to utilise mutations identified in congenital myasthenic syndromes to study the interactions of the muscle acetylcholine receptor (AChR) and its anchoring protein, Rapsyn.Widely quoted publications suggest that Rapsyn interacts with the M3-M4 intracellular loop of the AChR alpha, beta and epsilon subunits, however we have identified several kinships in which mutations in the M… more
Amount: £0
Design and development of a breathing powered prosthetic prototype
<p>The input required to control a prosthetic device greatly defines the subsequent precision that can be achieved. Robust mechanisms that are low-cost often use musculoskeletal motion for control. However, this often limits the level of control and applicability issues can arise when the system that is augmented also generates the power and drives the control. A device that is powered and contro… more
Amount: £0
Assessing the effect of the Xrn1 exoribonuclease on global and specific rates of protein synthesis
<p>Gene expression is a complex process requiring the coordination of transcription, transcript turnover, translation and proteostasis. When coordinated, these processes can be adapted to allow cells to respond to changes in growth rate and during differentiation. How these processes are coordinated remains a long-standing question. The exoribonuclease Xrn1 is proposed to coordinate transcription… more
Amount: £0
Investigating the role of cyclin-dependent kinases in the regulation of DNA repair by non-homologous end-joining
<p>DNA double-strand breaks (DSBs) are highly toxic lesions that can drive genome instability and cancer. In human cells, most DSBs are repaired by the non-homologous end joining (NHEJ) pathway, except when they occur during DNA replication or mitosis when NHEJ is toxic and can generate chromosomal translocations. NHEJ must therefore be tightly regulated to maintain genome stability. However, lit… more
Amount: £0
Analysis of neurodegenerative diseases progression, at a single cell level, with Deep Neural Networks
<p>The aim of the project is to investigate neurodegenerative diseases, by determining novel neuronal cell phenotypes, classify them and to develop a step wise neurodegenerative disease<br>progression map. Stem cells differentiation technology allows scientists to access neurons involved in pathology of various neurodegenerative disease, however, there is big gap in good methods to investigate di… more
Amount: £80,000
Optogenetic analysis of the neural function of 5-HT-glutamate co-transmission
<p>This research investigates the relationship between 5-HT neurons and two key brain functions: sleep-wake changes and fear learning. Of particular interest is the role in these processes of glutamate co-released from 5-HT neurons. Two approaches will be used. One approach is based on recent evidence that glutamate is preferentially released from 5-HT neurons firing at low frequencies, whereas 5… more
Amount: £80,000
Structural studies of bacterial nucleic acid transport proteins
<p>Horizontal gene transfer contributes to genetic plasticity in bacteria and is of great clinical relevance as it contributes to the spread of antibiotic resistance genes. One mechanism of horizontal gene transfer in bacteria is transformation. While the phenomenon of transformation has been known for many decades, little is known about the mechanistic steps of exogenous DNA uptake into bacteria… more
Amount: £0