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Open Access Award 2019/20
open access award 2017/18
Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Structural insights into the Rifin protein family of the malaria parasite
<p>Members of the RIFIN family of <em>Plasmodium falciparum</em> are expressed on the surfaces of infected erythrocytes, where they are one of the few surface protein families exposed to the host immune system. They are members of a broader protein family, including the stevors, virs and pirs that are expressed across malaria parasites. This project aims towards the structure of the extracellular… more
Spatio-temporally multiplexed 2-photon imaging determining neural coding principles of sensory perception.
How does the brain encode the contents of sensory perception and translate them into meaningful neuronal representations of our environment? Although we know approximately how sensory input is routed through different brain areas, each extracting distinct aspects of the percept, the neuronal language used to represent sensory experiences remains elusive. Our work aims is to unravel the coding str… more
Trade Liberalisation and Diet-Related Non-Communicable Diseases.
This research will empirically examine the effect of trade liberalisation on diet and alcohol-related non-communicable diseases (NCDs) with two key goals in mind. Firstly, this research aims to assess whether liberalisation increases or decreases unhealthy food and alcohol consumption via changing social environments. Elements of social environments known to affect food and alcohol consumption in… more
The Problem with Practicality: Rethinking the Function of Late-Medieval Medical Recipes 1400-1550.
I intend to examine late-medieval manuscripts containing English medical recipe collections, in order to establish a clearer and more nuanced understanding of their cultural functions. I aim to analyse the navigational aids, reader annotation and manuscript context of these collections, in order to complicate the current critical conception that they only or predominantly served practical functio… more
Professor Christine Korsgaard (Arthur Kingsley Porter Professor of Philosophy, Harvard University)will visit Oxford December 1 -3 for a series of 3 lectures, The Moral and Legal Standing of Animals , where she will also seek to discuss our resulting moral obligations towards them. This event capitalises on her presence to bring together a group of philosophers, ethicists, lawyers, veterinarians, … more
Reading and Replicating Bodies: Mimicry in Medicine and Culture, 1790-1914 (an Interdisciplinary workshop).
This one-day workshop will bring together scholars working on the subject of mimicry in the history of medicine. The event will explore how, in nineteenth-century medicine and culture, to know a body was to replicate it. It will ask how medical practices and representations sought to mechanically imitate the body with perfect accuracy, from anatomical models and drawings to prosthetics. How did s… more
Public Engagement Provision.
Collaborative outreach programme with Mark Withers and the Orchestra of the Age of Enlightenment (OAE): This programme builds on a history of collaborations between Russell Foster and musician Mark Withers dating back to 1997 which includes a major education project, A Celebration of Life on Earth", with the OAE. We will start our work from scientific research into sleep, the eye and body clocks.… more
Oxford part of Kenya MOP renewal 2010 - 2015. Transfer to Philip Bejon.
<p>This proposal is for core funding for an integrated programme of health research conducted in East Africa through the KEMRI Wellcome programme. Core funding supports the essential infrastructure and personnel to provide a platform on which the specific research components, are built. The research programme it self is embedded in a national research institute (KEMRI) but has collaborative links… more
Open access award 2014/15.
Experience as Evidence: The Sciences of Subjectivity in Healthcare, Policy and Practice.
The patient experience has long been regarded as a valuable source of knowledge in healthcare. Traditionally framed as the 'subjective' counterpart to 'objective' biomedical knowledge, experiential knowledge has been used to critique biomedical reductionism and promote patient-centred care. Bolstered by patient activism, health consumerism, and concerns over standards of care, over the last fifty… more
Characterising control of mycobacterial growth in patients with TB disease and M. tuberculosis infection.
TB can be viewed as a continuous spectrum extending from sterilising immunity, quiescent M. tuberculosis (M.tb) infection, and active disease. Identifying phenotypic subgroups within this spectrum is challenging and the tools we use are currently imperfect. An understanding of protective immunity against TB disease is lacking, as are predictors of risk of disease progression, biomarkers of respon… more
Role of interleukin 33 in intestinal homeostasis
<table> <tbody> <tr> <td>This research project will focus on the identification of the role of interleukin 33 (IL-33) in intestinal homeostasis. IL-33 belongs to the IL-1 family and has been shown to mediate both pro-inflammatory and anti-inflammatory processes depending on the disease context. Although IL-33 is produced in high amounts in the intestine little is known about its rol… more
Developing a novel single dose prime-boost vaccine against malaria
<table> <tbody> <tr> <td>The main goal of this project is to develop a new vaccine delivery platform for a single dose prime-boost immunisation regime that would be applicable to current and future vaccines requiring a prime-boost approach. This novel platform is based on the technological advance of the production ofmicrocapsules from biodegradable polymers, which can… more
Understanding the role of the RNA-binding protein Mmi1 in coupling transcription and RNA processing by the exosome complex.
Regulation of gene expression in eukaryotes is integral to establishment of the cell identity and survival. Synthesis of pre-mRNA in eukaryotes is catalyzed by RNA polymerase II (Pol II). The level and quality of RNA is controlled by the RNA gsurveillance h machinery represented by the highly conserved exosome complex of 3'-5' exonucleases, which is therefore responsible for establishing the bala… more
The Art in Global Health - Exhibition Extension