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Search results (Displaying 96 grants)

Total grants
96
Total funders
1
Total recipients
1
Earliest award date
24 Jan 2017
Latest award date
03 Dec 2019
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ISARIC
<p style="margin-left: 0cm; margin-right: 0cm">The International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) is a federation of clinical research networks&nbsp;whose aim is to prevent illness and deaths from infectious diseases outbreaks. This aim is supported by two key objectives: (i) To generate and disseminate clinical research evidence for outbreak-prone infectious d… more
Amount: £3,099,568
Amount: £1,171,479
Innovative biomedical engineering and computational science to improve the management of critical illness in resource-limited settings
<p>Our project&rsquo;s primary objective is to provide proof-of-principle that new technology can help improve the care of critically ill patients with infectious diseases in resource-limited settings. To achieve this objective we will develop a new inter-disciplinary &lsquo;innovations for critical care&rsquo; team within Oxford University Clinical Research Unit (OUCRU), a Wellcome Africa Asia P… more
Amount: £2,526,611
Innovative biomedical engineering and computational science to improve the management of critical illness in resource-limited settings
<p>Our project&rsquo;s primary objective is to provide proof-of-principle that new technology can help improve the care of critically ill patients with infectious diseases in resource-limited settings. To achieve this objective we will develop a new inter-disciplinary &lsquo;innovations for critical care&rsquo; team within Oxford University Clinical Research Unit (OUCRU), a Wellcome Africa Asia P… more
Amount: £1,503,910
Plasmodium vivax Volunteer Infection Studies in Thailand
<p>Vivax malaria remains a major global health problem. Because of the existence of a hypnozoite stage and the clinical relapses this causes, elimination strategies are more difficult to design and implement successfully than for falciparum malaria. Vaccines and new well-tolerated&nbsp;anti-relapse drugs are badly needed. To accelerate vaccine&nbsp;development, we will develop and assess the feas… more
Amount: £1,523,437
Amount: £2,000,000
Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Amount: £98,762
Neuroscience
Not available
Amount: £2,980,000
Amount: £2,460,000
Amount: £2,228,000
Amount: £2,720,000
Amount: £2,580,000
Structural basis of use of ion flow across the bacterial inner membrane to power secretion and motility
Bacteria need to control import/export of charged molecules across their relatively impermeable membrane(s) which also house many nano-machines critical for motility and hence infection. These processes are often driven by harvesting the energy stored in ion gradients across the inner-membrane by ion flow through inner-membrane resident channels. Unpublished work from my group has demonstrated th… more
Amount: £2,286,425
Selfish selection of de novo mutations in the male germline
Understanding the factors determining the occurrence of de novo mutations (DNMs) in the human genome is central to genetic disease and genome biology. DNMs arise predominantly in the male germline and increase in frequency with paternal-age. Despite the fact that germline mutation rates are intimately linked to spermatogenesis, very little is known about testicular homeostasis in humans. This pro… more
Amount: £1,439,158
Spatiotemporal dissection of vascular heterogeneity
Endothelial cells (ECs) are essential for organ development, homeostasis and regeneration, yet we still know relatively little about the early steps of their formation. I have shown that ECs from different embryonic lineages preferentially contribute to distinct parts of the vasculature; paraxial mesoderm (PXM) is the major source of lymphatic ECs, but its contribution to blood vessel endotheliu… more
Amount: £1,322,791
Consolidating practice in social science research for Ebola, DRC.
<p style="margin-left: 0cm; margin-right: 0cm">The response to the Ebola epidemic in North Kivu and Ituri provinces, Democratic Republic of Congo has been described as one of the most complex that national and international communities have had to face.Given the complexity of this protracted epidemic, social science research has become a critically important part of the response in order to help … more
Amount: £75,161
Genomic Medicine and Statistics
<p>Genomic Medicine and Statistics (GMS) is a four-year doctoral training programme at the University of Oxford, established in 2008. Over the next 5-year funding period our goal is to train future leaders in the application of genomics to advance human health, equipping them with skills sets spanning experimental and analytical genomic science to address current roadblocks by innovating and real… more
Amount: £5,685,862
Cellular Structural Biology
<p>Structural biology continues to provide one of the most important toolsets for molecular biosciences. It also underlies many crucial industries, supporting biomedical advances in drug and vaccine development and molecular engineering. It continues to develop at pace. The recent electron cryo-microscopy revolution has been transformative and advances in tomographic methods prove likely to soon … more
Amount: £5,685,862