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Search results (Displaying 32 grants)

Total grants
32
Total funders
1
Total recipients
1
Earliest award date
19 Feb 2007
Latest award date
31 Dec 2007
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Molecular mechanisms governing X chromosome inactivation; a model for understanding epigenetic regulation of the genome in differentiation and development.
The key goal of this proposal is to understand the mechanism of X chromosome inactivation. In this unusual form of genetic regulation the genes on a single X chromosome in female cells are co-ordinately silenced early in development, conferring dosage equivalence between XX females and XY males. The X inactivation process is regulated by a cis-acting non-coding RNA, the X inactive specific transc… more
Amount: £4,856,474
Supplementary funding
The research conducted by the Thailand-based clinical research programme has changed the treatment of both severe and uncomplicated malaria, and melioidosis. The central aim of this proposal is to develop and evaluate effective and practical means of diagnosing, treating, and, if possible, preventing the main tropical diseases responsible for significant morbidity and mortality in rural areas of … more
Amount: £2,500,000
Thailand Major Overseas Programme - Oxford costs
The research conducted by the Thailand-based clinical research programme has changed the treatment of both severe and uncomplicated malaria, and melioidosis. The central aim of this proposal is to develop and evaluate effective and practical means of diagnosing, treating, and, if possible, preventing the main tropical diseases responsible for significant morbidity and mortality in rural areas of … more
Amount: £3,820,498
Supplementary funding
This is a proposal for core support to the KEMRI Wellcome Programme in Kenya. The twin overriding aims of the programme are to conduct research to the highest international scientific and ethical standards on health problems which are major causes of morbidity and mortality in Africa, and to build strong and sustainable national and regional research capacity. Over the last five years we produced… more
Amount: £1,000,000
Core support 2005-2010 for Major Overseas Programme at Kenya
This is a proposal for core support to the KEMRI Wellcome Programme in Kenya. The twin overriding aims of the programme are to conduct research to the highest international scientific and ethical standards on health problems which are major causes of morbidity and mortality in Africa, and to build strong and sustainable national and regional research capacity. Over the last five years we produced… more
Amount: £1,843,996
Major Overseas Programme - Viet Nam.
Elevated plasma levels of fibrinogen have been shown to be an independent risk factor for ischaemic heart disease and have also been associated with other thrombotic disorders such as stroke, peripheral arterial disease and venous thrombosis. This risk may be mediated in part via altered fibrin structure as we have demonstrated in myocardial infection (MI) patients and their first-degree relativ… more
Amount: £4,471,312
Strategic Award for the Wellcome Trust Centre for Human Genetics.
The Wellcome Trust Centre for Human Genetics was established in 1994 to undertake research into the genetic basis of common diseases. The scientific objective of the Centre is to gain insight into mechanisms controlling genetic susceptibility to human disease including the localization and identification of disease genes, functional characterization of gene variants responsible for susceptibilit… more
Amount: £2,020,414
Human and Veterinary Vaccinology.
Vaccination offers the most cost-effective approach to infectious disease control but new vaccines are need for many diseases of human and livestock, particularly in developing countries. There is a translational gap between academic research on vaccines and late phase II trials, the point where proof of concept has been demonstrated and large vaccine companies will invest to achieve licensure. … more
Amount: £3,400,000
Co-trimoxazole prophylaxis among children with severe malnutrition.
This project aims to test the hypothesis that mortality after initial stabilisation among Kenyan children with complicated severe malnutrition is due to ongoing vulnerability to infectious disease, and that co-trimoxazole prophylaxis will reduce mortality. It is postulated that the effects of co-trimoxazole will be direct, by preventing life threatening bacterial infections and malaria, and indir… more
Amount: £1,242,027
Bacterial chromosome dynamics.
The objectives are to provide a comprehensive and integrated understanding of how the processes of DNA replication, recombination and chromosome segregation shape bacterial chromosome organization. Furthermore, the coordination between these processes with growth and cell division will be explored. The studies will use a combination of cellular in vivo studies and experiments in vitro that will h… more
Amount: £1,672,071
Mechanisms of cardiovascular pleiotropy and buffering in Cited2 deficiency.
Aims: Our aim is to understand the developmental and molecular mechanisms of pleiotropy and buffering in Cited2 deficiency Key Goals: a) We will use conditional knockouts to identify the developmental mechanism of cardiac pleiotropy in Cited2 deficiency. Specifically, we will identify the spatial and temporal locus of Cited2 action in cardiovascular patterning and cell fate; and develop new tools… more
Amount: £1,327,435
Genetic, neurological and cognitive determinants of success and failure in learning a first language.
This research aims to identify causes of specific language impairment (SLI) at the etiological, neurobiological and cognitive levels of description, and to understand the links between SLI and other neurodevelopmental disorders. A twin study will be conducted with the goal of identifying aspects of the phenotype that are heritable and so might be useful in molecular genetic studies. In addition, … more
Amount: £3,235,192
Imagining and Practicing Imperial and Colonial Medicine, 1870-1960 conference to be held at St Antony's College, Oxford, on 10-12 January 2008.
A conference considering the study of imperial and colonial medicine in general has been noticeably absent over the past several years, while the study of imperial and colonial medicine has received grater attention from both experienced and younger scholars alike. There have been gatherings considering specific locations, such as the successful and important History of Medicine in South East Asi… more
Amount: £3,000
Ethical challenges in the release and publication of ethnicity-related research results. The case of the MalariaGEN Consortium.
A key ethical issue facing genomic epidemiology research is the collection and release of data on the ethnic background of research participants. Consideration of ethnicity is crucial to the interpretation of population genetic research, but current open access data release models in the field have been argued to pose ethical problems regarding the release of potentially sensitive ethnic informa… more
Amount: £90,487
Evolution, Eugenics and Christian Mission; charitable healthcare in transition: London and New York, 1865 - 1940.
I propose to research three Christian mission agencies active in urban settings in order to analyse the impact of eugenics upon their practical medical work. To enable a national comparative study I have selected the London City Mission, the New York City Mission and the Salvation Army, active in both cities. To place these groups in their appropriate context I will also study the eugenics societ… more
Amount: £89,976
Negotiating Competing Agendas: Collaborations Between International Health Organizations and Their National Counterparts in the Fight Against Cancer, 1925-1975.
My research will focus on understanding the interactions of national and international health organizations dedicated to fighting cancer, with an emphasis on the competing research agendas of British, American and global health associations. The project will be divided into three sections, with the first analyzing national opposition to the founding of international health collaboratives. The sec… more
Amount: £82,318
Clinical studies on enteric fever in Kathmandu Nepal.
With the spread of drug resistance in some areas of the world but an apparent return to sensitivity in other areas the treatment of enteric fever is becoming more complicated and trials conducted over the last decade have not provided all the answers. The main goals of the period of research (18 months after my MSc) are to investigate the optimal treatment for enteric fever. I will achieve this… more
Amount: £68,728
Oxford Forum for Medical Humanities Symposium 'Neuroethics'.
Neuroethics The symposium will have three sessions, arranged around the ethical implications of the rapidly advancing field of neuroscience, addressing key areas of brain imaging, pharmacological cognitive enhancement and artificial intelligence. We shall also discuss the extent to which new definitions of biological abnormalities within neuroscience may exempt individuals from prosecution or po… more
Amount: £3,500
An open label randomised comparison of injectable artesunate and quinine in children with severe falciparum malaria.
Severe malaria kills over one million African children each year. Parenteral quinine is the current treatment for in Africa, but in Asia artesunate was shown (SEAQUAMAT trial) to reduce the mortality of severe malaria by 35% compared with quinine and is now recommended by WHO. A meta-analysis of studies comparing artemether (a compound similar, but less well absorbed than artesunate) with quinine… more
Amount: £2,362,500