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Your search ‘’ returned 21 results in ‘All grant fields’

Search results (Displaying 21 grants)

Total grants
21
Total funders
1
Total recipients
1
Earliest award date
30 Jan 2009
Latest award date
14 Dec 2009
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Amount: £1,500
Next-Generation Disease Association Analyses: Low pass Sequencing and High Density SNP genotyping for type 2 diabetes.
This application, from groups in the UK and US, builds on an impressive record of productive collaboration on the genetic basis of type 2 diabetes (T2D) and related conditions, and in development of community resources and statistical methods for complex trait analyses. The research has two principal objectives. The first involves operational implementation and rigorous evaluation of alternative … more
Amount: £1,337,646
Next-Generation Disease Association Analyses: Low pass Sequencing and High Density SNP genotyping for type 2 diabetes.
This application, from groups in the UK and US, builds on an impressive record of productive collaboration on the genetic basis of type 2 diabetes (T2D) and related conditions, and in development of community resources and statistical methods for complex trait analyses. The research has two principal objectives. The first involves operational implementation and rigorous evaluation of alternative … more
Amount: £1,255,277
The Kadoorie Biobank study.
The Kadoorie Biobank Study is one of the world's largest blood-based prospective studies of the environmental and genetic determinants of chronic diseases. During 2004-8, 515,000 adults aged 35-74 from 10 regions across China were enrolled, with extensive data collection by questionnaire and physical measurement, and with storage of blood (including DNA) for future research. Funding is requested … more
Amount: £2,500,000
Heathen Sufferings: The Church Missionary Society and mental ill-health at Mengo Hospital, Uganda, 1897-1944
I will explore constructions of mental ill-health at the Church Missionary Society (CMS) Mengo Hospital, Uganda, 1897-1944, in order to redress a historiographical bias towards discourses of colonial governance in colonial psychiatry. By introducing a medical mission as a distinct context for psychiatric discourses, my research will develop a new framework in which psychiatric practices can be examined.
Amount: £85,006
Resource centre for genomic epidemiology of malaria.
Our goal is to understand how natural genome variation in human, Plasmodium and Anopheles populations affects the epidemiology and biology of malaria, and to use this knowledge to develop more effective ways of controlling the disease. This requires a concerted effort by many research groups around the world. We propose to establish a resource centre that will support this community effort by: - … more
Amount: £5,701,081
Treatment for mothers with postnatal depression to improve child outcome: a randomised controlled trial.
Maternal postnatal depression (PND) affects around 13% of mothers. Compared to children of non-depressed mothers, children of mothers with PND are more likely to have cognitive, behavioural, and attachment problems. Treating maternal depression alone does not improve child outcome. Thus attention should focus on improving mother-child interaction. We aim to examine whether a treatment to enhance … more
Amount: £1,478,756
Defining the role of primaquine in malaria elimination.
Primaquine is the only widely available P.falciparum gametocytocide and the only radical treatment for vivax and ovale malaria. It could play a pivotal role in malaria elimination, but it is currently underused because of uncertainty over safety, efficacy and dosage. We propose conducting a series of epidemiological, clinical and pharmacological studies in Thailand to determine the optimum treatm… more
Amount: £2,352,217
Signalling circuitry controlling hyperpolarization and dilatation in resistance arteries.
In arteries, endothelial cells continually suppress blood pressure by hyperpolarizing smooth muscle. This represents a primary and fundamental physiological control mechanism independent of NO/prostacylin, modulated by autacoids and disrupted by the endothelial dysfunction caused by cardiovascular disease. We discovered hyperpolarization follows KCa-channel (KCa2.3 and 3.1) activation, and that t… more
Amount: £1,277,584
Functional studies of the ATP-sensitive potassium channel.
KATP channels play key roles in many cell types by coupling the metabolic state of the cell to its electrical activity. Gain-of-function mutations in the KATP channel subunits Kir6.2 and SUR1 cause human neonatal diabetes (ND). In some patients diabetes is permanent, but in others it is transient. A few patients also experience neurological symptoms. The overall goals of this research programme… more
Amount: £1,878,171
Oxford Centre for Neural Circuits and Behaviour.
We aim to establish a centre for basic neuroscience research, consisting of an interactive and complementary group of leading neuroscientists and students, all focussed on a key problem in neurobiology: the biological mechanisms of adaptive behaviour. In order to address this goal we will develop new genetic technologies for dissecting neural circuits. We realize that the key to understanding inf… more
Amount: £5,000,000
Amount: £1,440
Viet Nam Major Overseas Programme Core Grant Renewal 2010-2015.
Infectious diseases remain a very real global threat. In addition to the endemic infections there has been emergence of new, often zoonotic, diseases and the rise of drug resistance among all major pathogens. Asia is the epicentre of these changes. Within a four hour flight of Vietnam live half the world s human population and 75% of the world s poultry. The region is a global hot spot for the em… more
Amount: £9,391,741
Blimp1/PRDM1 functional roles in adult homeostasis.
The zinc finger transcriptional repressor Blimp-1/PRDM1 plays key roles guiding development of multiple cell types, due to its ability to globally change gene expression patterns. New experiments demonstrate strong Blimp-1/PRDM1 expression in the intestinal crypts of the adult gut. Additionally we have discovered that a novel isoform with structurally diverse zinc finger domains encoded by altern… more
Amount: £1,210,244
Centre of Excellence in Personalised Healthcare.
The overall theme of our proposal is personalised healthcare. Much of the 20th century was devoted to developing therapies that are broadly effective in a large proportion of the population. However, from the management of long-term conditions such as diabetes or high blood pressure to drug-based cancer therapies, it has become clear that conditions are best managed by taking into account how the… more
Amount: £8,002,101
Molecular magnetic resonance imaging with microparticles of iron oxide.
We have designed, developed and applied a new class of molecular magnetic resonance imaging agent. Ligand-conjugated iron oxide microparticles (MPIO). For the majority of contrast agent approaches there has been no attempt to apply the agent in the very roles for which they were developed. However, for MPIO, where contrast effects are highly conspicuous and readily quantifiable, there is a compel… more
Amount: £1,275,054
Genetics of the people of the british isles and their faces.
We will add 1,000 samples from the Ancient British western fringe, and from the eastern areas that most reflect the Anglo-Saxon influence, to the 3,500 already collected (rural areas, all four grandparents from the same area). A further 1,500 samples will be collected from populations surrounding the British Isles. Genetic variation determining facial features will be identified through associati… more
Amount: £2,067,797
Genetic dissections of hippocampal function.
The aim is to provide a unifying account of the hippocampus, using the latest molecular biological techniques, along with a novel in vivo voltammetric approach for recording tissue oxygen concentrations. I will investigate the role of synaptic plasticity in two, distinct forms of hippocampus-dependent spatial memory, and test the novel hypothesis that SRM and SWM reflect associative and non-assoc… more
Amount: £1,312,954
Population genomics of the Neisseria: evolution of commensalism and virulence.
The evolution of distinct phenotypes within the genus Neisseria, will be studied with a 'population genomics' approach. Isolate collections representative of the genetic and phenotypic diversity of the Neisseria that inhabit human musosa will be employed. Subsets of these collections, chosen on the basis of phenotypic and genetic criteria, will be characterised at the whole genome level with co… more
Amount: £1,779,732
The magnetoencephalographic signature of genetic and pharmacological variation in catechol-O-methyl transferase (COMT)
1) To identify whether a functional polymorphism in COMT, known to affect dopamine metabolism and cognitive and emotional processing, influences the localisation and/or timing of cortical activity, as measured using magnetoencephalography (MEG) during performance of various dopamine-dependent neuropsychological tasks. 2} To determine the effects of acute pharmacological inhibition of COMT, using … more
Amount: £2,933