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CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Implementation of ISARICC's 2018-2022 Strategic Plan
<p>Bridging funds for transition to ISARICC's 2018-2022 Strategic Plan</p>
<p>'Sacred Water' – an engagement project run by artist Lena Bui, was a creative space for researchers at OUCRU-Nepal and people living in the Kathmandu Valley to discuss health with a focus on water. However, the earthquake of 2015 caused many participants to reflect on a wider view of health. Lena became interested in what people turn to for a sense of wellbeing - cultural… more
Vacation Scholarships 2017 - University of Oxford
<p>Vacation Scholarships 2017-University of Oxford</p>
Value in people award.
Wellcome Trust Clinical PhD Programme at the University of Oxford: a study of epigenetic changes in FOXP3 in regulatory T-cells and potential clinical application in allogeneic bone marrow transplantation.
The proposed research will study the influence of demethylating agents on the development and expansion of regulatory T-cells (Tregs). Tregs provide a crucial cellular mechanism of peripheral tolerance and are important in controlling Graft-versus-Host disease (GvHD). Their development is dependent upon the expression of the transcription factor, FOXP3. However, in humans, transient FOXP3 express… more
Wellcome Trust Clinical PhD Programme at the University of Oxford: gene therapy for multiple endocrine neoplasia type 1 (MEN1).
Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by the combined occurrence of parathyroid, pancreatic islet, anterior pituitary and adrenocortical tumours for which effective treatments are not available. The MEN1 gene is located on chromosome 11q13 and encodes a 610 amino acid protein, MENIN. MENIN has functions in transcriptional regulation and genome … more
Wellcome Trust Clinical PhD Programme at the University of Oxford: Determining the role of Foxp3 regulatory T-cells in vivo.
Current understanding of the immune system has been radically influenced by the discovery of regulatory T-cells. No longer are aggressive and destructive immune cells thought to be the only players. There is more of an emphasis on the immune cells involved in policing immune responses and creating a state of tolerance to self antigens, so preventing autoimmunity. Regulatory T-cells (T-Reg cells… more
MA in History of Medicine
Health and Medicine in the Nineteenth-Century Navy.
This pilot project aims to determine the whereabouts and content of sources of potential relevance to a study of health and medicine in the nineteenth century Royal Navy. This is an extremely under-researched area. While we are aware of large bodies of rich source material, it has been impossible to evaluate fully its potential. Archives at certain institutions, such as the Naval Museum and Roy… more
Open Access Award.
Vacation Scholarships 2008.
Development of thalamocortial connections in mouse barrel cortex: Role of subplate neurons.
The overall aim is to understand the development of synaptic interactions in the early thalamus-subplate-layer 4 microcircuit of mouse barrel cortex. Two specific objectives have been identified: 1. To determine the developmental profile of synaptic function at three identified synapses within this microcircuit during early postnatal development, and 2. To test the hypothesis that spike timing-dependent plasticity can explain the developmental changes at these three synapses.
The molecular cell biology of the Leishmania parasite / host macrophage interface.
The molecular cell biology of the Leishmania parasite I host macrophage interface. Our overall objective is to define the cell biological processes contributing to the Leishmania parasite's success in growing within a parasitophorus vacuole in the host macrophage. We will focus specifically on the role of the short, immotile flagellum which we postulate to have a sensory role. Specific Aims 1. To… more
Identification of the molecular mechanisms of Il-23-driven intestinal inflammation.
Maintenance of the integrity of the gastrointestinal tract requires a delicate balance between proinflammatory T effector cell responses directed at pathogenic organisms and anti-inflammatory T regulatory cell (Treg) responses toward the commensal flora . In individuals suffering from inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, this balanced intestinal im… more
A SYSTEMATIC APPROACH TOWARDS UNDERSTANDING INNATE IMMUNITY AGAINST TRYPANOSOMES.
The project aims to provide a cellular and molecular view of innate immunity against trypanosomes. Despite recent findings a detailed structural explanation of the events occurring at the molecular and cellular level is missing. Specifically, inter-related and complementary aims are to: (1) Follow the morphologically distinct stages from uptake of the lytic factor to trypanosome cell death by ge… more
Reducing childhood mortality in the tropics. Development of a combined antimalarial-antibacterial rectal formulation for community use.
Summary not available
Request for a contribution towards a meeting 'Governing Biobanks-What are the challenges?' to be held at the University of Oxford from 24-26 June 2008.
The purpose of this conference is to explore some of the complex and challenging issues that emerge from the governance of biobanks. Genomics research is on the crest of a wave, with discoveries of the variants responsible for common diseases, such as obesity and breast cancer, becoming increasingly frequent. These advances are aided by the rapid technological advances in genotyping, the accumula… more
The structural basis of the binding specificity of the family of SIRP paired receptors.
The structural basis of the SIRP family of receptors will be determined. (i) X-ray crystallography will be carried out on the ligand binding domains of the SIRP beta and gamma (SIRP alpha has already been completed) (ii) The structure of the complex between CD47 and SIRPalpha will be determined working on extensive preliminary data. (iii) The structure of the three extracellular domains of SIRP a… more