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CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Implementation of ISARICC's 2018-2022 Strategic Plan
<p>Bridging funds for transition to ISARICC's 2018-2022 Strategic Plan</p>
<p>'Sacred Water' – an engagement project run by artist Lena Bui, was a creative space for researchers at OUCRU-Nepal and people living in the Kathmandu Valley to discuss health with a focus on water. However, the earthquake of 2015 caused many participants to reflect on a wider view of health. Lena became interested in what people turn to for a sense of wellbeing - cultural… more
Vacation Scholarships 2017 - University of Oxford
<p>Vacation Scholarships 2017-University of Oxford</p>
Ethical Lifespan Enhancement.
Current medical and policy strategies have doubled our lifespans over the past century, with a number of corresponding benefits to individuals and societies. However, the cost of these strategies has been a progressive loss of wellbeing amongst the very old, along with a rapid increase in the distributed burdens of aged care. The first goal of this research is to reframe our existing medical stru… more
Sun Dial: Night Watch.
In the project 'Sun dial : Night watch', scientist Katharina Wulff and artist Susan Morris will create artwork for display at the John Radcliffe Hospital, Oxford. Our aim is to raise public awareness of so-called 'social jetlag': the rising drift between our innate biological clock and manmade routines that modem society imposes upon us. The effects of electric lighting, of organising ourselves a… more
An investigation into the neurophysiological biomarkers of Parkinsons disease in closed loop deep brain stimulation.
The aim of this project is investigate whether there exist improved neurophysiological biomarkers of Parkinson s disease (PD) over and above the pathological beta synchrony band already described and to examine whether these enhanced biomarkers can be used to improve treatment with deep brain stimulation (DBS) through their modulation of stimulation in a closed loop setting. Specifically, we will… more
Genetic basis of craniofacial malformations.
1. Prospective ascertainment of patients requiring craniofacial surgery at the four participating centres. We will aim to recruit a minimum of 150 patients (with parents) annually. 2. Identification of new monogenic causes of craniofacial malformation within this cohort using massively parallel sequencing. We will use 16 lanes of Illumina-based sequencing of captured whole exomes in patients or … more
Regulation of growth and TORC1 signalling by the novel evolutionarily conserved amino acid transporter, SLC38A10: a new player in amino acid sensing?.
We will dissect out the functions and mechanism of action of the growth regulatory SLC38A10 transporter in Drosophila, using the combination of genetic and molecular genetic approaches we have developed in our pioneering studies of amino acid sensing by the PATs. We will employ analysis of mutant animals and somatic mutant clones, RNAi and overexpression studies to determine in which tissues SLC3… more
Open Access award.
Generation of an antibody library against transcription factors.
<table> <tbody> <tr> <td>Adapting specific anti-peptide phage combinatorial library technology to a peptide capture phage assay in generating anti-transcription factor antibodies</td> </tr> </tbody> </table>
Comprehensive assessment of the role of methylation in Obesity and Type 2 Diabetes, using a combined genetics and cell biology approach
p(L)ace of change
p(L)ace of change (PoC) is a media led investigation into the rapid development occurring in Viet Nam; the impact this change has on health and wellbeing and what communities have to say about it. For this first phase, we will deliver a series of community authored films tied together with professional media, developed in consultation with scientists. The resulting DVD will then be used in facili… more
Biomedical Vacation Scholarship
Structural Studies of the Influenza RNA Polymerase
Structural and Biophysical Characteristics of the interaction of the PfRh proteins with their ligands and inhibitory antibodies:understanding an interactionessential for the invasion of erythrocytes by the malaria parasite.
Specifying the role of Asterless (Asl) in centrosome formation and function through characterization of its dynamic localization at centrosomes
Investigating the role of PCP signalling during Anterior Visceral Endoderm migration in the mouse embryo
Molecular Genetic Analysis of Cell Function and Behaviour in the Drosphila Accessory Gland, a Novel Model for Prostate Biology