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CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Implementation of ISARICC's 2018-2022 Strategic Plan
<p>Bridging funds for transition to ISARICC's 2018-2022 Strategic Plan</p>
<p>'Sacred Water' – an engagement project run by artist Lena Bui, was a creative space for researchers at OUCRU-Nepal and people living in the Kathmandu Valley to discuss health with a focus on water. However, the earthquake of 2015 caused many participants to reflect on a wider view of health. Lena became interested in what people turn to for a sense of wellbeing - cultural… more
Vacation Scholarships 2017 - University of Oxford
<p>Vacation Scholarships 2017-University of Oxford</p>
A randomised controlled trial to test the effectiveness of a brief intervention for weight management for obese adults in primary care.
<p>Obesity, a major cause of chronic disease, affects 25% of adults. Even a small loss of weight is likely to reduce the risk of chronic diseases occurring, such as diabetes that are the consequence of being overweight. We can use lessons learnt from tobacco control and apply these to obesity. GPs make unsolicited brief interventions frequently on smoking and problem drinking, which are known to … more
FLICC (Front of pack food labelling: Impact on consumer choice)
<p>Since 2006, retailers and manufacturers in the UK have begun using front of pack (FOP) nutrition labelling on foods. Presently, around four fifths of foods in UK supermarkets carry FOP labelling. There have been many studies of consumer understanding of FOP labelling, and of use of FOP labelling in experimental settings. However, little is known about how consumers use FOP labelling in real-li… more
International Severe Acute Respiratory Infection Consortium (ISARIC)
It has become increasingly recognized from a series of recent outbreaks of emerging pathogens of global public health importance that mounting clinical research in response toa rapidly emerging infectious disease is extremely challenging, often delayed and of increasing importance. The Consortium will establish a new paradigm for collaborative clinical research in rapidly emerging public health t… more
Healing the Other: a comparative history of missionary healthcare among an Amazonian people, Suriname-Brazil 1959-1994.
Healing the Other is a comparative study of two missionary primary healthcare systems established among the Trio, a native Amazonian population who live on either side of the border separating Suriname and Brazil. From 1959 until 1994, Franciscan priests and Protestant missionaries were granted exclusive access for the provision of healthcare by the states of Brazil and Suriname respectively. As … more
Influence of host genetics and Mycobacterium tuberculosis strain variation on macrophage function and TB clinical outcome.
The contribution of host genetics and Mtb strain variation to bacterial dissemination in TB are not fully understood. An impairment of macrophage function under the influence of these two factors may help explain the pathogenesis of TB and its different clinical presentations. This project has three key goals. 1) To determine whether host genetic variants of genes related to phagosomal function a… more
A proof of concept Phase IIb efficacy trial to evaluate the protective efficacy of a booster MVA85A vaccination administered to BCG primed infants in the Western Cape.
Summary not available
Open access award.
Infection, Immunology and Translational Medicine-'Towards the development of auniversal influenza vaccine:Investigation of heterosubtypic humoral and cellular immune responses to influenza induced by vaccincation with viral
Seasonal influenza epidemics and pandemics are associated with a non-trivial mortality, morbidity and carry a heavy socioeconomic burden. Vaccination is still the primary strategy for the prevention and control of influenza despite the limitations of currently licensed vaccines and their requirement of periodic reformulation and annual revaccination of at-risk individuals. A first generation T-ce… more
Infection, Immunology and Translational Medicine - 'Control of intestinal immunity by the autophagy protein ATG16L1'
Autophagy is a process of recycling intracellular components in response to starvation or stress. It is also involved in clearance of defective organelles, intracellular pathogens and protein aggregates. Polymorphisms in autophagy genes were recently associated with susceptibility to inflammatory bowel disease (IBD); however the mechanisms responsible for this correlation remain unclear. Clinical… more
Infection, Immunology and Translational Medicine - 'Establishment of a transgenic zebrafish model to study the innate immune response to melanoma'
Although immune mechanisms, such as cytokines produced by immune cells in response to the tumour environment, may provide protection against cancer by elimination of transformed cells, they may also aid tumour development by immunosuppressive mechanisms. Epigenetic mechanisms that alter chromatin landscape, enabling the unwrapping of transcriptional programs play important roles in all cellular p… more
Infection, Immunology and Translational Medicine - 'The role of novel members of the IL-1 family in psoriasis'
The IL-1 family cytokines IL-33 and IL-36s are increased in inflammatory skin disease but little is known about their function. In this project we will perform a systematic analysis of the role of IL- 1 family members in inflammatory skin diseases. We will determine how they influence disease initiation and perpetuation. The study will focus on in vivo as well as in vitro evaluation of IL- 33, IL… more
Infection, Immunology and Translational Medicine - 'Investigating the mechanism of non-catalytic tyrosine phosphorylated receptor triggering'
The central goal of this project is to investigate the mechanism of non-catalytic tyrosine phosphorylated receptor (NTR) triggering. These receptors share a number of features. For example, they contain, or associate with adaptor molecules that contain, tyrosine residues that are phosphorylated by extrinsic kinases, and have comparatively small extracellular domains which bind surface-associated … more
Wellcome Trust Clinical PhD Programme at the University of Oxford: 'Autoimmunity in idiopathic epilepsies and encephalopathies of childhood'.
Immune mechanisms are thought to be involved in the pathological disease process in a significant number of childhood (and adult) epileptic syndromes, and seizure related disorders (i.e. encephalitis). The hypothesis that the body's immune system plays an important role in these disorders is based on the following observations: 1) Occurrence of highly specific autoantibodies to important neuronal… more
Wellcome Trust Clinical PhD Programme at the University of Oxford: 'Approaches to understanding regulatory pathways in atherosclerosis using genome-wide mapping of open chromatin with FAIRE-seq in foam cells.
Approaches to understanding regulatory pathways in atherosclerosis using genome-wide mapping of open chromatin with FAIRE-seq in foam cells. Atherosclerotic vascular disease is the leading cause of morbidity and mortality worldwide. Atherosclerosis is an inflammatory condition and the lesions are packed with immune cells. A key pathogenic role is played by lipid loaded macrophages known as foam c… more