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Search results (Displaying 124 grants)

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Earliest award date
17 Jan 2014
Latest award date
07 Dec 2017
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CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Amount: £21,120
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Amount: £22,186
Implementation of ISARICC's 2018-2022 Strategic Plan
<p>Bridging funds for transition to ISARICC's 2018-2022 Strategic Plan</p>
Amount: £144,634
Discretionary Award
<p>'Sacred Water' &ndash; an engagement project run by artist Lena Bui, was a creative space for researchers at OUCRU-Nepal and people living in the Kathmandu Valley to discuss health with a focus on water.&nbsp; However, the earthquake of 2015 caused many participants to reflect&nbsp;on a wider view of health. Lena became interested in what people turn to for a sense of wellbeing&nbsp;- cultural… more
Amount: £40,000
Vacation Scholarships 2017 - University of Oxford
<p>Vacation Scholarships 2017-University of Oxford</p>
Amount: £15,500
Public Engagement Provision
<table> <tbody> <tr> <td>Ageing &nbsp; societies and diseases of modern living require truly novel, efficacious and &nbsp; safe medicines. Increasing investment in R&amp;D has not improved the &nbsp; efficiency of this endeavor. There is an urgent need for novel, validated &nbsp; drug targets. To facilitate this, the Wellcome Trust and other organisations &nbsp; have sponsored large-scale genome-… more
Amount: £123,176
Public Engagement Provision.
1. How can we improve the development of assisted living technologies (ALTs) by and for people with multi-morbidity and declining health? 2. How can we better promote the customisation and use of such technologies inthe home and the community by individuals, their carers and support services? 3. How can we ensure that ethical and existential concerns (what matters to people?; what are homes for?;… more
Amount: £27,000
Amount: £270,061
The role of the innate immune system in repair and regeneration following myocardial infarction.
<table> <tbody> <tr> <td> <p>After &nbsp; myocardial infarction in the adult heart, a stereotyped innate immune &nbsp; response drives persistent inflammation, leading to impaired healing, scar &nbsp; formation, adverse remodelling and heart failure.&nbsp; In contrast, the murine neonatal heart &nbsp; heals by regeneration after injury, without scar or fibrosis.&nbsp; In both the adult and neonat… more
Amount: £319,816
Using next generation chromatin conformation capture approaches to study the dynamics and
<p>&nbsp;</p> <p>Gene expression is controlled by complex networks of regulatory elements in the genome, involving promoters, enhancers, silencers and insulator elements. Chromatin conformation capture methods can be used to analyse these <em>cis</em>-acting networks by measuring the physical interactions between the regulatory elements involved. Recently, a high-throughput approach, Capture-C, h… more
Amount: £161,117
Analysis of bacterial genetic variation through long and short read sequencing, using graphical
<p>This PhD focuses around the development of methods for representation and analysis of genomic variation using long and error-prone reads, such as those from Oxford Nanopore Technologies and Pacific Biosciences. There are two key goals. 1) Our group has recently developed a novel &ldquo;FM-index-like&rdquo; data structure that allows representation of a partial order alignment (related to a mul… more
Amount: £161,117
Multisensory Convergence and Integration in Thalamic and Cortico-Thalamo-Cortical Circuitry
<p>The thalamus occupies a unique position. All sensory information, but olfaction, travels through the thalamus before reaching its cortical destination. Furthermore, it has been found to be mediating communication between several cortical areas. However, the functional anatomy and role of such cortico-thalamo-cortical circuits are poorly understood in sensory processing. The thalamus has also b… more
Amount: £161,117
Beyond the hospital: strengthening dialogue to improve health outcomes.
This project aims to stimulate dialogue between patients with central nervous system infections (CNSIs), their carers, and researchers, hospital staff and rehabilitation organizations, to strengthen capacity for communication, engagement between researchers and the public, and to identify factors that may improve recovery post-discharge. The project wil be conducted at the Hospital for Tropical D… more
Amount: £30,000
This is an application to fund a Community Engagement and Ethics Coordinator in the Thailand Major Overseas Programme for two years.
The Thailand Overseas Programme has more than three decades of experience in conducting clinical trials in resourced limited settings in Asia and Africa. Increasingly we recognise that engaging with the communities we work in is essential to the success of these trials, regardless of geography and discipline. Equally important, is identifying and addressing ethical issues related to medical resea… more
Amount: £190,068
Tracing early mammalian lineage decisions by single cell genomics.
Lewis Wolpert famously called gastrulation the most important time in your life. During this fascinating process, a pluripotent stem cell population in the early embryo gives rise to the three germ layers from which all organ systems develop. Cell signalling and transcriptional networks are known to regulate aspects of gastrulation, but the precise mechanisms have not been investigated at the sin… more
Amount: £274,971
Effect of beta2-adrenergic receptor agonists on the acetylcholine receptor clustering pathway in congenital myasthenic syndromes.
Congenital myasthenia contains a group of inherited disorders affecting neuromuscular transmission. The host laboratory has previously shown that beta2-adrenergic agonists, such as salbutamol, are particularly beneficial in a subgroup of patients with congenital myasthenia, typically involving DOK7 mutations. DOK7 is a member of the acetylcholine receptor (AChR) clustering pathway, a pathway cruc… more
Amount: £266,148
Divergent roles of Smad1 and Smad2 in patterning the early mammalian embryo.
<table> <tbody> <tr> <td>The&nbsp;TGF? secreted growth factors bone morphogenetic protein (BMP) and nodal play&nbsp;crucial roles in cell fate specification during vertebrate gastrulation.&nbsp;BMPs, acting via Smad1/5/8 induce 'posterior' or extra-embryonic mesoderm (including the germ cell lineage), whereas nodal signals through Smad2/3&nbsp;specify the 'anterior' primitive streak and its deriv… more
Amount: £37,977
The relationship between progenitor populations and the organisation of local excitatory synaptic circuits within the mammalian cortex.
<table> <tbody> <tr> <td>A &nbsp; fundamental question in neuroscience is how neurons establish their &nbsp; functional identity and specific synaptic connections with other cells. &nbsp; However, we still know very little about how, or when, the functional &nbsp; identityand connectivity of an individual neuron becomes constrained during &nbsp; its development. Recent technical advances now make… more
Amount: £16,837
Childhood pneumococcal pneumonia in Nepal: novel immunodiagnostic methods and transcriptomic investigation of pathophysiology
<Synopsis>1.3 million children &lt;5 years of age die from pneumonia annually worldwide, with Streptococcus pneumoniae (pneumococcus) responsible for 740 000 of these deaths, despite increasing uptake of pneumococcal conjugate vaccines (PCV). However, accurate diagnostics for pneumococcal pneumonia, and a clear characterisation of the pathway from healthy nasopharyngeal carriage to disease, are l… more
Amount: £309,020