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Search results (Displaying 42 grants)

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Earliest award date
31 Jan 2017
Latest award date
30 Sep 2020
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Amount: £200,000
CHIM - Shigella sonnei in Vietnamese adults - Development funds
<p>Diarrhoea remains a major cause of childhood morbidity and mortality globally. The vast majority of the 2 billion<br> annual diarrhoeal infections occur in low and middle-income countries (LMICs). Members of the genus <em>Shigella</em><br> are key agents of diarrhoea in LMICs, and <em>S. sonnei </em>is replacing <em>S. flexneri </em>as the predominant species globally.<br> There is a necessity… more
Amount: £21,120
Malaria Controlled Human Infection Model - application development
<p>We wish to apply for funds to develop the malaria CHIM application. These are for a Co-investigators/stakeholders meeting to be held in Bangkok, Thailand, on 30<sup>th</sup> and 31<sup>st</sup> January 2018 and to support a writing meeting of the PIs in February 2018 in Kilifi, Kenya.</p>
Amount: £22,186
Implementation of ISARICC's 2018-2022 Strategic Plan
<p>Bridging funds for transition to ISARICC's 2018-2022 Strategic Plan</p>
Amount: £144,634
Discretionary Award
<p>'Sacred Water' &ndash; an engagement project run by artist Lena Bui, was a creative space for researchers at OUCRU-Nepal and people living in the Kathmandu Valley to discuss health with a focus on water.&nbsp; However, the earthquake of 2015 caused many participants to reflect&nbsp;on a wider view of health. Lena became interested in what people turn to for a sense of wellbeing&nbsp;- cultural… more
Amount: £40,000
Vacation Scholarships 2017 - University of Oxford
<p>Vacation Scholarships 2017-University of Oxford</p>
Amount: £15,500
The impact of vaccine platform on the cellular drivers of humoral immunity
<p>The focus of this Fellowship proposal is on how vaccine platform affects the cellular drivers of humoral immunity, specifically memory B cells (mBCs) and T follicular helper (Tfh) cells. I will compare the leading <em>Plasmodium falciparum</em> blood-stage malaria candidate &ndash; RH5 &ndash; in two vaccine platforms: heterologous viral vectors (chimp adenovirus 63 prime, Modified Vaccinia An… more
Amount: £250,000
The Ethics of Genome Editing in Livestock
<p>Genome editing in livestock (GEL) could potentially be used to mitigate urgent global problems of infectious disease, antimicrobial resistance, global warming, and animal suffering while also increasing agricultural productivity. Despite its imminence and potentially transformative potential, there has been minimal ethical debate about GEL. This project will provide the first in-depth philosop… more
Amount: £227,968
The role of diurnal intracellular chloride changes in cortical network activity and plasticity.
<p>Cyclical changes between sleeping and waking states are a fundamental feature of mammalian physiology. During these different states, our brains exhibit distinct patterns of network activity and different capacities to learn. An understanding of the cellular mechanisms that underlie these processes is important to fully appreciate how daily changes in brain function contribute in health and di… more
Amount: £250,000
DNA origami: how do you fold a genome?
<p>Recent advances in DNA sequencing technology mean that it is now possible to identify genetic variants in patients with specific diseases which either cause or alter their risk of developing that disorder. However, linking these variants to the genes they regulate and the symptoms of the condition itself is time-consuming and challenging. The overarching aim of this project is to develop high-… more
Amount: £35,850
Politics, elections, and inclusive decision-making: Do political institutions affect health?
Do political institutions influence the health of populations? Political institutions once seemed fixed and stable, but now appear to be flexible and open to change. This project seeks to uncover whether changing political institutions could affect health. Political institutions are the rules that govern who participates and how they participate in decision-making processes within societies; for … more
Amount: £201,914
Dengue Controlled Human Infection Model - Development Grant
<p>Following a positive response to the&nbsp;preliminary submission for grant funding&nbsp;to&nbsp;establish a Dengue Controlled Human Infection Model (Dengue-CHIM )&nbsp;in Ho Chi Minh City, Vietnam, I am submitting this request&nbsp;for a small grant&nbsp;to assist in refining and&nbsp;developing the main proposal prior to&nbsp;final&nbsp;submission in March 2018.</p> <p>&nbsp;</p> <p>During … more
Amount: £23,690
A realist review of community engagement with health research
<p>The project will conduct a comprehensive review of community engagement using a realist review approach appropriate for tackling the conceptual complexity and practical diversity of the field. A review team with worldleading expertise in the theory and practice of CE will be supported by an advisory panel of internationally renowned realist review scholars. The review will begin with engagemen… more
Amount: £260,250
Exploring mechanisms of enhancer action in erythropoiesis
<p>DNA sequences called enhancers control gene expression in time and space by activating genes during key cell-fate decisions. The specific combinations of genes activated by enhancers contribute to cellular behaviour, genetic predisposition to disease and phenotypic variation between species. My aim is to understand precisely <em>how</em> enhancers activate genes during differentiation.</p> <p… more
Amount: £250,000
Closing the loop on neuronal oscillations: Motor networks take centre stage
<p>The idea that brief periods of coherence or phase-locking in rhythmic activity mechanistically facilitate&nbsp;communication across distributed cortical networks is hotly debated. It is thought to underlie processes like attention and working memory yet much of the evidence remains correlative. I propose to design and utilise a digital circuit to optogenetically entrain or damp rhythmic activi… more
Amount: £250,000
Neural mechanisms supporting environment evaluation in humans and their breakdown in clinical disorders
<p>My goal in this proposal is to understand the neurocognitive mechanisms by which individuals evaluate their environment.</p> <p>&nbsp;</p> <p>First, I will use computational modelling to characterise how individuals adjust their estimates of the reward rate in an environment on a trial by trial basis. I will manipulate the reward rate over time and model how individuals respond to these chan… more
Amount: £250,000
Enhancing Summative Assessment of Practical Science: A Systemic Approach
What makes plants grow? What are stars made of? Scientists answer such questions by collecting and interpreting data. Sometimes scientists use experiments where they change conditions and study the effects of changes. For instance, in the case of plant growth, the amount of sunlight and water can be manipulated to see if they make any difference. Scientists use different approaches to practical w… more
Amount: £270,773
Facing ethics: Identifying ethical issues in computational phenotyping research
<p>Computational phenotyping research uses big data methods to refine the diagnosis of rare genetic diseases. Photographs (and other biomedical data) of people with genetic syndromes are used to train machine-learning algorithms to identify the phenotypic features associated with different disorders. The data are obtained from consortia of clinicians and researchers involved in rare disease resea… more
Amount: £27,408
Healing Heathen Lands: Protestant Missions and Public Health in British India, 1855-1956
<p>This project will explore the role of Protestant missions in the making of British Indian public health by tracing the interactions between evangelical, colonial and vernacular sources. It will argue that Protestant missionaries in South Asia did not merely play a complementary role to imperial biomedicine. It will examine the ways in which missions&nbsp;contributed towards shaping colonial he… more
Amount: £174,774