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Search results (Displaying 93 grants)

Total grants
93
Total funders
1
Total recipients
1
Earliest award date
19 Feb 2007
Latest award date
04 Dec 2017
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Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Amount: £98,762
Neuroscience
Not available
Amount: £2,980,000
Amount: £2,460,000
Amount: £2,228,000
Amount: £2,720,000
Amount: £2,580,000
Molecular mechanisms governing X chromosome inactivation; a model for understanding epigenetic regulation of the genome in differentiation and development.
The key goal of this proposal is to understand the mechanism of X chromosome inactivation. In this unusual form of genetic regulation the genes on a single X chromosome in female cells are co-ordinately silenced early in development, conferring dosage equivalence between XX females and XY males. The X inactivation process is regulated by a cis-acting non-coding RNA, the X inactive specific transc… more
Amount: £4,856,474
Supplementary funding
The research conducted by the Thailand-based clinical research programme has changed the treatment of both severe and uncomplicated malaria, and melioidosis. The central aim of this proposal is to develop and evaluate effective and practical means of diagnosing, treating, and, if possible, preventing the main tropical diseases responsible for significant morbidity and mortality in rural areas of … more
Amount: £2,500,000
Thailand Major Overseas Programme - Oxford costs
The research conducted by the Thailand-based clinical research programme has changed the treatment of both severe and uncomplicated malaria, and melioidosis. The central aim of this proposal is to develop and evaluate effective and practical means of diagnosing, treating, and, if possible, preventing the main tropical diseases responsible for significant morbidity and mortality in rural areas of … more
Amount: £3,820,498
Supplementary funding
This is a proposal for core support to the KEMRI Wellcome Programme in Kenya. The twin overriding aims of the programme are to conduct research to the highest international scientific and ethical standards on health problems which are major causes of morbidity and mortality in Africa, and to build strong and sustainable national and regional research capacity. Over the last five years we produced… more
Amount: £1,000,000
Core support 2005-2010 for Major Overseas Programme at Kenya
This is a proposal for core support to the KEMRI Wellcome Programme in Kenya. The twin overriding aims of the programme are to conduct research to the highest international scientific and ethical standards on health problems which are major causes of morbidity and mortality in Africa, and to build strong and sustainable national and regional research capacity. Over the last five years we produced… more
Amount: £1,843,996
Major Overseas Programme - Viet Nam.
Elevated plasma levels of fibrinogen have been shown to be an independent risk factor for ischaemic heart disease and have also been associated with other thrombotic disorders such as stroke, peripheral arterial disease and venous thrombosis. This risk may be mediated in part via altered fibrin structure as we have demonstrated in myocardial infection (MI) patients and their first-degree relativ… more
Amount: £4,471,312
How does the Pericentriolar Matrix function in Centrosome Biology?
<p>Centrosomes are the major microtubule organising centres in many animal cells. They form when centrioles assemble an electron dense matrix of pericentriolar material (PCM) around themselves. Several hundred proteins are concentrated in the PCM, including many cell-cycle regulators and cell signalling molecules, and centrosomes function as important coordination centres within the cell. The und… more
Amount: £1,639,125
Data sharing platforms to improve treatment outcomes in neglected tropical diseases
<p>We will develop data-sharing platforms to assimilate and collaboratively interrogate global data on i) schistosomiasis ii) soil transmitted helminths, iii) visceral leishmaniasis, iv) melioidosis and v) scrub typhus. This proposal will support the development of the technical platform and curation of data from tens of thousands of patients enrolled to treatment trials and programmatic data of … more
Amount: £1,406,744
Bone Morphogenetic Protein signalling and stromal-epithelial interaction in intestinal inflammation and carcinogenesis.
<p>The intestinal mucosa is a complex ecosystem and the epithelium has a dynamic relationship with underlying stroma. Key aspects of intestinal homeostasis and disease states, including inflammatory bowel disease and cancer are characterized by the interdependence of the epithelial and stromal compartments.</p> <p>Inter-compartmental cell-signalling pathways regulate intestinal epithelial cell f… more
Amount: £1,792,405
Using genetic diversity to map fine-scale epidemiology in malaria
<p>The recent evolution of artemisin-resistant strains of P.falciparum in Southeast Asia have highlighted the need for a deeper understanding of the genetic epidemiology of malaria and for more strategic implementation of malaria control resources. Assessment of the efficacy of these control efforts requires accurate and standardised estimates of epidemological parameters, such as transmission in… more
Amount: £0
Statistical models of gene-environment interactions
<p>This PhD focuses on developing statistical methods to discover gene &ndash; environment (G-E) interactions. To date there has been some interest in testing for G-E interactions in animal models, but limited success in uncovering examples of G-E interactions in humans. This is in part due to the problem of exposure assessment, or rather, because representative data on the environment of a numbe… more
Amount: £0