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Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Cellular Structural Biology
OXION - Membrane Transport in Health and Disease
Chromosome and Developmental Biology.
Genomic medicine and statistics
Student Elective Prize for Ms Katherine Talbot
Are increases in intracranial pressure at high altitude correlated with acute mountain sickness?
Student Elective Prize for Mr Edmund Naylor
An evaluation of the effectiveness of home-based treatment of Multi-Drug Resistant Tuberculosis (MDR-TB) in Kwazulu-Natal, South Africa.
Student Elective Prize for Mr Adam Handel
Magnetoencephalographic (MEG) study of facial pain
Measuring the impact of naturally acquired immunity on the expression of Plasmodium falciparum variant surface antigens.
Plasmodium falciparum infected erythrocytes express on their surface, members of a diverse family of parasite molecules called PfEMP1 that are encoded by a family of 60 var genes. These molecules interact with the surface of host cells and mediate parasite sequestration in tissues including the brain, an important step in the pathogenesis of cerebral malaria. Although naturally acquired antibodie… more
Cryo-electron microscopy of pathogens and receptor complexes.
The program will use cryo-electron microscopy and three-dimension reconstruction to study pathogenic viruses and the effects of infection on cells. Much of the microscopy will be conducted under P3 conditions and is associated with the establishment of a Facility for the Examination of Infectious Particles in Oxford which will include contained high end cryo-microscopes. The topics explored will … more
Genetic control of cell fate decisions in the devloping mouse embryo.
We are studying the complex cellular interactions underlying early mammalian development, and in particular the signals provided by members of the TGFß superfamily of secreted growth factors. We have previously shown that nodal activity is required for primitive streak formation and anterior patterning during gastrulation, and at later stages for establishment of the L/R body axis. We also descri… more
How does the Pericentriolar Matrix function in Centrosome Biology?
<p>Centrosomes are the major microtubule organising centres in many animal cells. They form when centrioles assemble an electron dense matrix of pericentriolar material (PCM) around themselves. Several hundred proteins are concentrated in the PCM, including many cell-cycle regulators and cell signalling molecules, and centrosomes function as important coordination centres within the cell. The und… more
Data sharing platforms to improve treatment outcomes in neglected tropical diseases
<p>We will develop data-sharing platforms to assimilate and collaboratively interrogate global data on i) schistosomiasis ii) soil transmitted helminths, iii) visceral leishmaniasis, iv) melioidosis and v) scrub typhus. This proposal will support the development of the technical platform and curation of data from tens of thousands of patients enrolled to treatment trials and programmatic data of … more
Bone Morphogenetic Protein signalling and stromal-epithelial interaction in intestinal inflammation and carcinogenesis.
<p>The intestinal mucosa is a complex ecosystem and the epithelium has a dynamic relationship with underlying stroma. Key aspects of intestinal homeostasis and disease states, including inflammatory bowel disease and cancer are characterized by the interdependence of the epithelial and stromal compartments.</p> <p>Inter-compartmental cell-signalling pathways regulate intestinal epithelial cell f… more
Using genetic diversity to map fine-scale epidemiology in malaria
<p>The recent evolution of artemisin-resistant strains of P.falciparum in Southeast Asia have highlighted the need for a deeper understanding of the genetic epidemiology of malaria and for more strategic implementation of malaria control resources. Assessment of the efficacy of these control efforts requires accurate and standardised estimates of epidemological parameters, such as transmission in… more
Statistical models of gene-environment interactions
<p>This PhD focuses on developing statistical methods to discover gene – environment (G-E) interactions. To date there has been some interest in testing for G-E interactions in animal models, but limited success in uncovering examples of G-E interactions in humans. This is in part due to the problem of exposure assessment, or rather, because representative data on the environment of a numbe… more
Overcoming contraceptive discontinuation by overcoming side-effects: paving the way for personalized contraception in Ethiopia
<p>In the developing world, millions of women discontinue hormonal contraception due to the experience of debilitating physiological side-effects (e.g. excessive and irregular bleeding), yet the causes of these adverse effects is not known. This project will be the first to test the hypothesis that side-effects are caused by unnecessarily high dosage of exogenous hormones in hormonal contraceptiv… more