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Search results (Displaying 113 grants)

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Earliest award date
26 Jan 2016
Latest award date
04 Dec 2017
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Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Amount: £98,762
Not available
Amount: £2,980,000
Amount: £2,460,000
Amount: £2,228,000
Amount: £1,137,787
Amount: £3,000,000
Amount: £2,720,000
Amount: £2,580,000
Structural insights into the Rifin protein family of the malaria parasite
<p>Members of the RIFIN family of <em>Plasmodium falciparum</em> are expressed on the surfaces of infected erythrocytes, where they are one of the few surface protein families exposed to the host immune system. They are members of a broader protein family, including the stevors, virs and pirs that are expressed across malaria parasites. This project aims towards the structure of the extracellular… more
Amount: £2,000
How does the Pericentriolar Matrix function in Centrosome Biology?
<p>Centrosomes are the major microtubule organising centres in many animal cells. They form when centrioles assemble an electron dense matrix of pericentriolar material (PCM) around themselves. Several hundred proteins are concentrated in the PCM, including many cell-cycle regulators and cell signalling molecules, and centrosomes function as important coordination centres within the cell. The und… more
Amount: £1,639,125
Data sharing platforms to improve treatment outcomes in neglected tropical diseases
<p>We will develop data-sharing platforms to assimilate and collaboratively interrogate global data on i) schistosomiasis ii) soil transmitted helminths, iii) visceral leishmaniasis, iv) melioidosis and v) scrub typhus. This proposal will support the development of the technical platform and curation of data from tens of thousands of patients enrolled to treatment trials and programmatic data of … more
Amount: £1,406,744
Bone Morphogenetic Protein signalling and stromal-epithelial interaction in intestinal inflammation and carcinogenesis.
<p>The intestinal mucosa is a complex ecosystem and the epithelium has a dynamic relationship with underlying stroma. Key aspects of intestinal homeostasis and disease states, including inflammatory bowel disease and cancer are characterized by the interdependence of the epithelial and stromal compartments.</p> <p>Inter-compartmental cell-signalling pathways regulate intestinal epithelial cell f… more
Amount: £1,792,405
Livestock, Environment and People (LEAP)
<p>Changes in the amount and type of animal-sourced food (ASF) we consume, and in the way they are produced, are critical drivers of global human health and environmental quality.&nbsp; The project will develop novel policy tools and interventions to allow more informed and effective action to be taken to maximise the health and environmental co-benefits of changes in ASF consumption.&nbsp; We sh… more
Amount: £4,391,572
Using genetic diversity to map fine-scale epidemiology in malaria
<p>The recent evolution of artemisin-resistant strains of P.falciparum in Southeast Asia have highlighted the need for a deeper understanding of the genetic epidemiology of malaria and for more strategic implementation of malaria control resources. Assessment of the efficacy of these control efforts requires accurate and standardised estimates of epidemological parameters, such as transmission in… more
Amount: £0
Statistical models of gene-environment interactions
<p>This PhD focuses on developing statistical methods to discover gene &ndash; environment (G-E) interactions. To date there has been some interest in testing for G-E interactions in animal models, but limited success in uncovering examples of G-E interactions in humans. This is in part due to the problem of exposure assessment, or rather, because representative data on the environment of a numbe… more
Amount: £0
An Empirical Study of Children and Adolescents' Perspectives on Testing Minors for their Genetic Predisposition to Psychiatric Disorders
<p>Predictive genetic testing for psychiatric disorders could help prevent or delay the development of debilitating conditions. However, the complex inheritance, incomplete penetrance, and variable expression in the genes underlying mental disorders make such testing a relatively poor predictive instrument. Empirical studies investigated the socio-ethical impacts of such testing from the perspect… more
Amount: £93,065
Increasing the flavivirus envelope glycoprotein dimer stability to elicit potent and broadly neutralizing antibody responses
<p>Dengue, a mosquito borne virus is estimated to infect 390 million people annually, leading to 25,000 deaths. Although recent approaches to vector control appear promising, it is generally agreed that the only way to achieve a step change is an efficacious vaccine. Recent Phase IIB&amp;III trials of a tetravalent live-attenuated-vaccine gave suboptimal efficacy and in particular appeared poor a… more
Amount: £2,547,704
An Analysis Of The Animal/Human Interface With A Focus On Low And Middle Income Countries
<p>Fleming Fund: supporting surveillance capacity for antimicrobial resistance</p> <p>The animal/human interface with a focus on low and middle-income counties</p> <p>Stephen Baker &ndash; Oxford University Clinical Research Unit, Viet Nam</p> <p>&nbsp;</p> <p>Our core research themes aim to make defining contributions to the understanding of infectious diseases transmission and susceptibility; t… more
Amount: £77,000