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Search results (Displaying 90 grants)

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Earliest award date
24 Jan 2017
Latest award date
05 Dec 2018
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Amount: £85,000
Circuit Mechanisms of Learning and Decision Making
<p>Decision making concerns every aspect of our lives. Despite substantial progress in understanding the brain regions involved in learning and decision making, the neuronal circuits that govern choice behaviour have remained elusive. This proposal aims at studying precise neuronal circuits underlying learning and decision making. We will focus on frontostriatal neuronal circuits, and how neuromo… more
Amount: £1,178,460
Development of compounds that inhibit RAS-effector protein-protein interactions in cancer using a single antibody domain drug surrogate emulator approach
Prof Rabbitts and colleagues from the Weatherall Institute of Molecular Biology have been awarded Seeding Drug Discovery funding to develop small molecules specifically targeting the RAS-effector protein-protein interactions. The RAS family of oncogenes is among the most frequently mutated in human cancers. Using minimal antibody fragments, the group has characterized an anti-RAS VH segment whos… more
Amount: £98,762
Not available
Amount: £2,980,000
Amount: £2,460,000
Amount: £2,228,000
Amount: £2,720,000
Amount: £2,580,000
What’s in a memory? Spatiotemporal dynamics in strongly coupled recurrent neuronal networks.
<p>Current models of memory postulate that impressions of the past are saved in synapses onto so-called engrams, groups of excitatory neurons that co-activate when a memory is recalled. However, many memories, like choreographed movements or spoken words, entail complex activation patterns that necessitate a high level of temporal control. Engram models cannot support such temporal activation pat… more
Amount: £1,665,855
Organising knowledge for flexible behaviour in the prefrontal-hippocampal circuitry
<p>Humans and animals can find new solutions to existing problems, and generalise existing knowledge to new situations. This flexibility relies on internal models of the relationships and causes that govern our world. Despite the importance of world-models to a wide class of behaviours and thus likely relevance to psychiatry, little is known about how they are represented in the brain. Recent evi… more
Amount: £2,276,345
Molecular basis of lipid traffic at interorganelle contact sites
<p>One unsolved mystery of cell biology is how lipids, made in the endoplasmic reticulum, travel to other cellular membranes. This question, originally deemed solved by the discovery of vesicular traffic, was recently spotlighted by the discovery of membrane contact sites (MCS), at which lipid transport proteins (LTP) accumulate. LTPs solubilize and transport lipids between two membranes in vitro… more
Amount: £2,267,367
Human in silico clinical trials in post myocardial infarction: mechanistic investigations into phenotypic electromechanical variability and response to treatment
<p style="margin-left: 0cm; margin-right: 0cm">The population of patients with ventricular damage following survival of myocardial infarction (MI) is rising, owing to the increased prevalence of coronary artery disease and improvements in treatment. Post-MI patients suffer from permanent myocardial damage, and this increases risk of sudden death and cardiac mechanical dysfunction, with potential … more
Amount: £1,634,247
Mechanobiological control of immune cell activation
<p>Biomedical sciences increasingly recognise the importance of mechanobiology in health and disease. While most mechanisms of the immune response are adequately explained by cell-biology, biochemistry, and genetics, many of its features profoundly depend on biomechanical aspects. <strong>One such scenario involves the ability of immune cells to differently respond to antigens with similar bindin… more
Amount: £98,263
How does the Pericentriolar Matrix function in Centrosome Biology?
<p>Centrosomes are the major microtubule organising centres in many animal cells. They form when centrioles assemble an electron dense matrix of pericentriolar material (PCM) around themselves. Several hundred proteins are concentrated in the PCM, including many cell-cycle regulators and cell signalling molecules, and centrosomes function as important coordination centres within the cell. The und… more
Amount: £1,639,125
Data sharing platforms to improve treatment outcomes in neglected tropical diseases
<p>We will develop data-sharing platforms to assimilate and collaboratively interrogate global data on i) schistosomiasis ii) soil transmitted helminths, iii) visceral leishmaniasis, iv) melioidosis and v) scrub typhus. This proposal will support the development of the technical platform and curation of data from tens of thousands of patients enrolled to treatment trials and programmatic data of … more
Amount: £1,406,744
Bone Morphogenetic Protein signalling and stromal-epithelial interaction in intestinal inflammation and carcinogenesis.
<p>The intestinal mucosa is a complex ecosystem and the epithelium has a dynamic relationship with underlying stroma. Key aspects of intestinal homeostasis and disease states, including inflammatory bowel disease and cancer are characterized by the interdependence of the epithelial and stromal compartments.</p> <p>Inter-compartmental cell-signalling pathways regulate intestinal epithelial cell f… more
Amount: £1,792,405
Using genetic diversity to map fine-scale epidemiology in malaria
<p>The recent evolution of artemisin-resistant strains of P.falciparum in Southeast Asia have highlighted the need for a deeper understanding of the genetic epidemiology of malaria and for more strategic implementation of malaria control resources. Assessment of the efficacy of these control efforts requires accurate and standardised estimates of epidemological parameters, such as transmission in… more
Amount: £0
Statistical models of gene-environment interactions
<p>This PhD focuses on developing statistical methods to discover gene &ndash; environment (G-E) interactions. To date there has been some interest in testing for G-E interactions in animal models, but limited success in uncovering examples of G-E interactions in humans. This is in part due to the problem of exposure assessment, or rather, because representative data on the environment of a numbe… more
Amount: £0