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Replication for blood cell indicies associations. (360G-Wellcome-076113_L_04_Z)

We propose a pilot study to test the association of 100,000 specific polymorphisms with a range of common diseases using a two stage case-control study design. The study will include diabetes, breast cancer, cardiovascular disease, bipolar disorder, and other diseases (2,000 samples each), as well as two common control groups (up to 3,000 samples total) for further evaluation. Positive associations will form the basis for future biological studies. The results will be used to evaluate how best to optimise the design, implementation, analysis and cost efficiency of large-scale and genome-wide association studies in the future. We will examine features such as SNP selection, analysis methods, population structure, study size, the use of common controls, heterogeneity in sample collections, linkage disequilibrium and SNP tagging. The results will provide independent assessment of the coverage of SNP panels that are available to the community for genetic studies, including the output of the International HapMap Project. The project will help to establish a separate training programme in statistical genetics, and will lay the foundations for the development of an infrastructure for UK research in this area in future years.


18 Feb 2009

Grant details
Amount Awarded 29568
Applicant Surname Ouwehand
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2009-02-18T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Project Grant
Internal ID 076113/L/04/Z
Lead Applicant Prof Willem Ouwehand
Planned Dates: End Date 2010-01-31T00:00:00+00:00
Planned Dates: Start Date 2009-02-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
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