The interplay between the Notch and Wnt signalling pathways in somitogenesis. (360G-Wellcome-078380_Z_05_A)
The interplay between the Notch and Wnt signalling pathways in somitogenesis This project aims to investigate the potential crosstalk between the Notch and Wnt signalling pathways in the important process of somitogenesis. It is well established now that the Notch pathway plays a crucial role in somitogenesis during vertebrate embryogenesis in a variety of species. More recently it was shown that the Wnt pathway is also required for this process in the mouse embryo. It was also reported that Wnt may play a role upstream of Notch in this process. The first aim of the project is to confirm and extend preliminary findings that Notch may be upstream of Wnt in chick somitogenesis. The second aim of the project is to examine the level of interplay between the two pathways in both the mouse and the chick embryo. Establishing how the Notch and Wnt pathways control somitogenesis will be an important step in understanding how this process is regulated.
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Grant Details
| Amount Awarded | 4808 |
| Applicant Surname | Gibb |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2009-10-20T00:00:00+00:00 |
| Financial Year | 2009/10 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 078380/Z/05/A |
| Lead Applicant | Ms Sarah-Jane Gibb |
| Partnership Value | 4808 |
| Planned Dates: End Date | 2009-12-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |
| Sponsor(s) | Prof Paul Crocker |