A genomewide association study of refractive error in the 1958 British Birth Cohort. (360G-Wellcome-083478_Z_07_Z)
We propose a novel and timely two-stage genomewide association study of refractive error (RE) in a nationally representative population, the 1958 British Birth Cohort (1958BC). Our joint analysis approach will be informed by our recently completed lifecourse epidemiological investigation of environmental determinants [12] and our on-going candidate-gene association study [13], both within this population which provides unique opportunities for studying complex traits. Additional strengths inclu de: -our leadership of the ophthalmic component of the MRC-funded biomedical survey of the 1958BC at 44 years allowing primary myopia phenotype capture without misclassification -robust measurement of quantitative trait of RE in a random subsample (N=2093) -good power to detect modest effects (eg > 80% power to detect alleles contributing 10% variance) with likelihood of false discovery within reasonable limits -the extant 1958BC DNA bank funded by Wellcome Trust -prior inclusion of a sub sample of 1958BC in the WT Case Control Consortium [14]. -existing resources for the staff costs of the present proposal -high-throughput high quality genotyping (Illumina s Infinium technology) outsourced to commercial organisations with whom we have established links Our proposal adds value to substantial prior investment in the 1958BC as a national resource for biomedical research, as well as in our work on RE.
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Grant Details
Amount Awarded | 591024 |
Applicant Surname | Rahi |
Approval Committee | Populations and Public Health Funding Committee |
Award Date | 2007-10-18T00:00:00+00:00 |
Financial Year | 2007/08 |
Grant Programme: Title | Project Grant |
Internal ID | 083478/Z/07/Z |
Lead Applicant | Prof Jugnoo Rahi |
Other Applicant(s) | Dr Claire Simpson, Prof Andrew Webster, Prof Christopher Hammond, Prof Shomi Bhattacharya |
Partnership Value | 591024 |
Planned Dates: End Date | 2009-10-31T00:00:00+00:00 |
Planned Dates: Start Date | 2008-06-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |