Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

Cone photoreceptor rescue in inherited retinal degenerations. (360G-Wellcome-086868_Z_08_Z)

This project is to investigate whether slowing cone photoreceptor loss could be used as a widely applicable treatment to preserve sight in inherited retinal degenerations. Neurotrophic factors, apoptosis inhibitors and transplanted rods have previously shown promise, but key questions remain: 1. Are initial rescue effects maintained over time, or subsequently lost by accelerated apoptosis? 2. Can cone cell rescue still be achieved once all rods have degenerated (a common clinical scenario)? 3. Could rods transplanted into the vitreous slow cone degeneration (the vitreous is a clinically attractive site for cell transplantation)? These questions will be addressed using adeno-associated viral (AAV) gene transfer to achieve sustained intraocular levels of a promising neurotrophic factor with a clinical safety profile (GDNF - delivered to inner retinal cells by AAV serotype 2) and cone selective expression of a potent intracellular inhibitor of apoptosis (XIAP - delivered to photo receptors by AAV serotype 5). In the third experiment rod progenitors will be isolated and transplanted into the vitreous cavity. All experiments will be performed in a novel mouse model of rod-cone degeneration in which the cones are genetically labelled with a fluorescent probe, allowing repeated anatomical and functional tracking of the degeneration over time.


04 Dec 2008

Grant details
Amount Awarded 179898
Applicant Surname Lee
Approval Committee Clinical Interview Committee
Award Date 2008-12-04T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Research Training Fellowship
Internal ID 086868/Z/08/Z
Lead Applicant Mr Edward Lee
Planned Dates: End Date 2011-02-28T00:00:00+00:00
Planned Dates: Start Date 2009-03-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Robin Ali
Additional data added by GrantNav