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Novel resolution-phase macrophages restore post-inflammation tissue homeostasis (360G-Wellcome-087520_Z_08_Z)

While the objective of acute inflammatory resolution is for cell clearance and pro-inflammatory mediator catabolism, tissues must undergo a final process of restoration of tissue homeostasis. This is not only essential for immune recovery but it restores physiology and prepares tissues to mount appropriately-tempered inflammatory responses to future infections or injuries. On this theme, I identified a new population of macrophages found at sites of resolving inflammation that play a central rol e in this process, called resolution-phase (rM) cells. Through the release of unknown prostanoids and/or chemokines, rM trigger the repopulation of innate-type lymphocytes (rLYM), which are crucial for controlling acute inflammatory responses to subsequent infection/injury and curtailing mortality. Therefore, this application proposes to indentify the rM-derived signals that trigger lymphocyte repopulation and elucidate the lymphocyte subpopulation/s responsible for post-resolution protection. A lso, with access to human resolving inflammatory samples I will investigate whether signaling pathways that restore homeostasis in mice also occur in humans. Thus, I believe that tissues revert back to homeostasis after injury/infection in an active manner controlled by soluble mediators and cellular players inherent to pro-resolution processes. By uncovering these novel pro-homeostatic pathways I hope to advance our understanding of chronic inflammatory diseases and susceptibility to infection.


06 Apr 2009

Grant details
Amount Awarded 1481973
Applicant Surname Gilroy
Approval Committee Basic Science Interview Committee
Award Date 2009-04-06T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Senior Research Fellowship Basic
Internal ID 087520/Z/08/Z
Lead Applicant Prof Derek Gilroy
Planned Dates: End Date 2015-04-30T00:00:00+00:00
Planned Dates: Start Date 2009-05-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Patrick Maxwell
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