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·Pre-clinical assessment of small diameter conduit made from nanocomposite polymer for coronary artery bypass graft application (360G-Wellcome-088037_Z_08_Z)

Current synthetic grafts largely based on poly(tetrafluoroethane) or Dacron perform adequately as large calibre grafts but are not suitable for coronary artery bypass grafts (CABG) due to the small diameter of the coronary arteries, the low blood flow rates, and high occlusion rates resulting in thrombosis and intimal hyperplasia. There is a clinical need for a small diameter coronary artery bypass graft (CABG) (<5mm) that mimics the properties of native human artery, and this is to be developed by Professor Alexander Seifalian and colleagues at University College London. The conduits are to made from a novel patented polymer based on polyhexal oligomeric silsequioxanes and poly(carbonate urea) urethane. Funding has been sought to validate the small diameter cardiac bypass graft in an animal model, experiments that are required in accordance with the regulatory authority requirements for an implantable device.

£495,800

21 Apr 2009

Grant details
Amount Awarded 495800
Applicant Surname Seifalian
Approval Committee Technology Transfer Challenge Committee
Award Date 2009-04-21T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Translation Award
Internal ID 088037/Z/08/Z
Lead Applicant Prof Alexander Seifalian
Other Applicant(s) Mr G Hamilton
Planned Dates: End Date 2011-05-01T00:00:00+00:00
Planned Dates: Start Date 2009-04-02T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
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