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The fusion of optical and magnetic resonance spectroscopy technologies to deliver novel multimodal methods to investigate brain injury in adults and neonates. (360G-Wellcome-088429_Z_09_Z)

The aim of this fellowship is to combine two techniques currently being used to monitor brain injury in adults and neonates; near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS). I will start by developing a novel magnet compatible hybrid optical topography spectrometer (HOTS) that is a combination of broadband and frequency domain spectrometers. HOTS will give regional measurements (2-Dimensional images) of brain tissue total haemoglobin, haemoglobin oxygen saturation, re dox state of cytochrome-c-oxidase, water content, temperature and scattering properties. I will then fuse the HOTS with MRS at an instrumentation level (combining the fibre optics head holder with the MR head coil) and on a software level (image co-registration). MRS scanning provides anatomical information with high spatial resolution measurements of lactate, creatine, phosphocreatine and tissue temperature. The merging of HOTS and MRS can therefore provide complementary physiological informati on. I will test the combined technologies using tissue mimicking phantoms, before a range of in-vivo studies are carried out in adult and neonatal humans and piglets (neonatal animal model). I will then fuse the multimodality data from these studies using systems biology approach utilising a computational model of brain tissue physiology, allowing the translation of the signals from physiological data to clinical information.


23 Jun 2009

Grant details
Amount Awarded 528536
Applicant Surname Tachtsidis
Approval Committee Basic Science Interview Committee
Award Date 2009-06-23T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Research Career Development Fellowship
Internal ID 088429/Z/09/Z
Lead Applicant Dr Ilias Tachtsidis
Planned Dates: End Date 2014-12-31T00:00:00+00:00
Planned Dates: Start Date 2010-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Clare Elwell
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