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The fusion of optical and magnetic resonance spectroscopy technologies to deliver novel multimodal methods to investigate brain injury in adults and neonates. (360G-Wellcome-088429_Z_09_Z)

The aim of this fellowship is to combine two techniques currently being used to monitor brain injury in adults and neonates; near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS). I will start by developing a novel magnet compatible hybrid optical topography spectrometer (HOTS) that is a combination of broadband and frequency domain spectrometers. HOTS will give regional measurements (2-Dimensional images) of brain tissue total haemoglobin, haemoglobin oxygen saturation, re dox state of cytochrome-c-oxidase, water content, temperature and scattering properties. I will then fuse the HOTS with MRS at an instrumentation level (combining the fibre optics head holder with the MR head coil) and on a software level (image co-registration). MRS scanning provides anatomical information with high spatial resolution measurements of lactate, creatine, phosphocreatine and tissue temperature. The merging of HOTS and MRS can therefore provide complementary physiological informati on. I will test the combined technologies using tissue mimicking phantoms, before a range of in-vivo studies are carried out in adult and neonatal humans and piglets (neonatal animal model). I will then fuse the multimodality data from these studies using systems biology approach utilising a computational model of brain tissue physiology, allowing the translation of the signals from physiological data to clinical information.

£528,536

23 Jun 2009

Grant details
Amount Awarded 528536
Applicant Surname Tachtsidis
Approval Committee Basic Science Interview Committee
Award Date 2009-06-23T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title Research Career Development Fellowship
Internal ID 088429/Z/09/Z
Lead Applicant Dr Ilias Tachtsidis
Planned Dates: End Date 2014-12-31T00:00:00+00:00
Planned Dates: Start Date 2010-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Clare Elwell
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