How do separate populations of stem cellsinfluence each other in the visual system of the zebrafish? (360G-Wellcome-089594_Z_09_Z)
1) To investigate how various retinal inputs influence the growth of the optic tectum. How does a lack of retinal input alter the size, shape, proliferation and cellular organization of the tectum? What are the consequences for tectal proliferation and differentiation when retinal ganglion (RGC) axonal activity is abrogated? How does a lack of retinal input affect the pathways that regulate neurogenesis in the optic tectum? 2) To investigate how signalling between the retina and the tectum controls growth and shifting connections. Is the secreted Sonic hedghog (Shh) protein transmitted along retinal ganglion cell axons to the tectum? How does axonal transport of signalling molecules affect growth and differentiation in the optic tectum?
Where is this data from?
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Grant Details
Amount Awarded | 152244 |
Applicant Surname | Rouse |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2009-05-29T00:00:00+00:00 |
Financial Year | 2008/09 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 089594/Z/09/Z |
Lead Applicant | Ms Hannah Rouse |
Partnership Value | 152244 |
Planned Dates: End Date | 2013-09-27T00:00:00+00:00 |
Planned Dates: Start Date | 2009-09-28T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Claudio Stern |