How do separate populations of stem cellsinfluence each other in the visual system of the zebrafish? (360G-Wellcome-089594_Z_09_Z)

£152,244

1) To investigate how various retinal inputs influence the growth of the optic tectum. How does a lack of retinal input alter the size, shape, proliferation and cellular organization of the tectum? What are the consequences for tectal proliferation and differentiation when retinal ganglion (RGC) axonal activity is abrogated? How does a lack of retinal input affect the pathways that regulate neurogenesis in the optic tectum? 2) To investigate how signalling between the retina and the tectum controls growth and shifting connections. Is the secreted Sonic hedghog (Shh) protein transmitted along retinal ganglion cell axons to the tectum? How does axonal transport of signalling molecules affect growth and differentiation in the optic tectum?

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Grant Details

Amount Awarded 152244
Applicant Surname Rouse
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2009-05-29T00:00:00+00:00
Financial Year 2008/09
Grant Programme: Title PhD Studentship (Basic)
Internal ID 089594/Z/09/Z
Lead Applicant Ms Hannah Rouse
Partnership Value 152244
Planned Dates: End Date 2013-09-27T00:00:00+00:00
Planned Dates: Start Date 2009-09-28T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Claudio Stern