Mass Spectrometry Studies of Type IV Secretion Systems. (360G-Wellcome-090146_Z_09_Z)
The emergence of methicillin-resistant Staphylococcus aureus (MRSA), responsible for difficult to treat infections in humans has led to the identification of broad-host-range plasmids carrying antibiotic resistance, conjugated through Type IV Secretion Systems (T4SSs). The T4SS is one of several types of secretion systems that mediates the transport of macromolecules across cellular membranes [1-2]. They are extremely versatile: found in both Gram-negative and Gram-positive bacteria as well as some archaea, they are responsible for secreting a wide range of substrates, including monomeric proteins, multisubunit protein toxins and nucleoprotein complexes. 1) Determine the composition and interacting proteins of the complex using mass spectrometry-based proteomics. 2) Identify the stoichiometry of the complex. 3) Define distance restraints between interacting proteins.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
| Amount Awarded | 152244 |
| Applicant Surname | Yan |
| Approval Committee | Molecules, Genes and Cells Funding Committee |
| Award Date | 2009-07-21T00:00:00+00:00 |
| Financial Year | 2008/09 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 090146/Z/09/Z |
| Lead Applicant | Ms Jun Yan |
| Partnership Value | 152244 |
| Planned Dates: End Date | 2013-09-27T00:00:00+00:00 |
| Planned Dates: Start Date | 2009-09-28T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Gabriel Waksman |