Cancer Care. (360G-Wellcome-101307_Z_13_Z)

We have unprecedented access to UCLs Cancer Institute and Cancer Hospital, allowing us to follow ground-breaking trials from the lab to the ward; intertwining life and death stories of people affected by cancer with those of the dedicated researchers working to find a cure. Following 4-5 cancer patients we will join them as they embark on clinical trials. One of many examples is Dr Martin Pule, who is running the cellular immunotherapy CHILDHOPE trial. Dr Pule is engineering chimeric artific ial receptors to create anti-CD19 CAR augmented donor leukocyte infusions to specifically target and destroy cancer cells in patients with B Cell Leukemias. Although Martin will explain the science to the patient, for the audience to fully understand the science it is imperative to use CGI to take them inside the engineering process at a molecular level. Similarly, UCLs combined PET/MRI scanner (unique in the UK) means tumours can be visualized in a way not previously available. But we need render these images in 3D to make them friendly to the viewing audience. The film will use the unique precinct provided by this highly integrated Hospital and Institute to interweave stories of various examples of cutting edge science being used to save or prolong lives, and in some cases cure patients of their cancers completely. CGI will be used to break down the jargon used by the clinicians, allowing the viewer to appreciate the complex and astounding biomedical technology being deployed deep inside these patients bodies.