How pathogenic cytosol-dwelling bacteria escape from autophagy. (360G-Wellcome-104752_Z_14_Z)
Certain pathogenic bacteria can infect and live inside human cells. Most intracellular bacteria dwell inside membrane-surrounded vacuoles. Our group has discovered defense mechanisms in human cells that prevent the escape of bacteria from their vacuoles into the host cytosol. These defense mechanisms are very effective as only a handful of clinically relevant bacteria are able to conquer the cytosol. New work will investigate how cytosol-dwelling bacteria avoid detection and whether cellular def enses can be redirected against them.
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Grant Details
| Amount Awarded | 959957 |
| Applicant Surname | Randow |
| Approval Committee | Science Interview Panel |
| Award Date | 2014-07-08T00:00:00+00:00 |
| Financial Year | 2013/14 |
| Grant Programme: Title | Investigator Award in Science |
| Has the grant transferred? | No |
| Internal ID | 104752/Z/14/Z |
| Lead Applicant | Dr Felix Randow |
| Planned Dates: End Date | 2021-06-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-01-01T00:00:00+00:00 |
| Recipient Org: City | Swindon |
| Recipient Org: Country | United Kingdom |
| Region | South West |
| Research conducted at multiple locations? | Yes |
| Total amount including partnership funding | 959957 |